An effective Alzheimer's disease segmentation and classification using Deep ResUnet and Efficientnet.

IF 2.7 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Biomolecular Structure & Dynamics Pub Date : 2025-04-01 Epub Date: 2023-12-20 DOI:10.1080/07391102.2023.2294381
Battula Srinivasa Rao, Mudiyala Aparna, Jonnadula Harikiran, Tatireddy Subba Reddy
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Abstract

Alzheimer's disease (AD) is a degenerative neurologic condition that results in the deterioration of several brain processes (e.g. memory loss). The most notable physical alteration in AD is the impairment of brain cells. An accurate examination of brain pictures may help to find the disease earlier because early diagnosis is crucial to enhancing patient care and treatment outcomes. Therefore, an easy and error-free system for AD diagnosis has recently received much research attention. Conventional image processing techniques sometimes cannot observe the significant features. As a result, the objective of this research is to develop an accurate and efficient method for identifying AD using magnetic resonance imaging (MRI). To begin with, the brain regions in the MRI images are segmented using a powerful Deep ResUnet-based approach. Then, the global and local features from the segmented images are recovered using a Multi-Scale Attention Siamese Network (MASNet)-based network. After extracting the features, the Slime Mould Algorithm-based feature selection process is conducted. Finally, the stages of AD are categorized using the EfficientNetB7 model. The efficacy of the presented method has been tested using brain MRI scans from the Kaggle dataset and the AD Neuroimaging Initiative (ADNI) dataset, and it achieves 99.31% and 99.38% accuracy, respectively. Finally, the study results show that the suggested method is helpful for accurate AD categorization.

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使用 Deep ResUnet 和 Efficientnet 进行有效的阿尔茨海默病分割和分类。
阿尔茨海默病(AD)是一种神经系统退行性疾病,会导致多种大脑功能衰退(如记忆力减退)。阿尔茨海默病最显著的身体变化是脑细胞受损。准确检查脑部图片有助于更早地发现疾病,因为早期诊断对于加强病人护理和提高治疗效果至关重要。因此,一种简便、无差错的注意力缺失症诊断系统最近受到了研究人员的广泛关注。传统的图像处理技术有时无法观察到重要特征。因此,本研究的目标是开发一种利用磁共振成像(MRI)识别注意力缺失症的准确而高效的方法。首先,使用基于 Deep ResUnet 的强大方法分割 MRI 图像中的大脑区域。然后,使用基于多尺度注意力连体网络(MASNet)的网络从分割图像中恢复全局和局部特征。提取特征后,再进行基于 Slime Mould 算法的特征选择过程。最后,使用 EfficientNetB7 模型对 AD 阶段进行分类。我们使用 Kaggle 数据集和 AD Neuroimaging Initiative(ADNI)数据集的脑核磁共振扫描结果对所提出方法的有效性进行了测试,其准确率分别达到了 99.31% 和 99.38%。最后,研究结果表明,建议的方法有助于对注意力缺失症进行准确分类。
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来源期刊
Journal of Biomolecular Structure & Dynamics
Journal of Biomolecular Structure & Dynamics 生物-生化与分子生物学
CiteScore
8.90
自引率
9.10%
发文量
597
审稿时长
2 months
期刊介绍: The Journal of Biomolecular Structure and Dynamics welcomes manuscripts on biological structure, dynamics, interactions and expression. The Journal is one of the leading publications in high end computational science, atomic structural biology, bioinformatics, virtual drug design, genomics and biological networks.
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In silico identification and characterization of small molecule binding to the CD1d immunoreceptor. In silico screening of natural products as uPAR inhibitors via multiple structure-based docking and molecular dynamics simulations. In-silico development of multi-epitope subunit vaccine against lymphatic filariasis. 3D-QSAR and ADMET studies of morpholino-pyrimidine inhibitors of DprE1 from Mycobacterium tuberculosis. An effective Alzheimer's disease segmentation and classification using Deep ResUnet and Efficientnet.
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