Dose-Dense Chemotherapy Regimen for Breast Cancer Associated with Significant Decline in Ovarian Reserve.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-01 Epub Date: 2023-12-19 DOI:10.1089/jayao.2023.0079

Isaac J Chamani, Alexandra Gannon, Phillip T Connell, Ajit Bisen, Ertug Kovanci, Haleh Sangi-Haghpeykar, Terri Woodard, Laurie J McKenzie

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Abstract

Purpose: To determine the impact of dose-dense chemotherapy administration on ovarian reserve in women undergoing treatment for breast cancer. Patients and Methods: We conducted a retrospective cohort study of reproductive age women who underwent dose-dense chemotherapy regimens with doxorubicin hydrochloride and cyclophosphamide with or without paclitaxel for a new diagnosis of breast cancer. We compared pre- and post-treatment serum antimullerian hormone (AMH) levels and assessed changes in AMH over time. Results: Fifty-seven patients met inclusion criteria. Median pre-treatment AMH was 2.9 ng/mL, whereas post-treatment AMH was 0.1 ng/mL, demonstrating a dramatic reduction in AMH levels after treatment with a dose-dense regimen. This change was independent of age and was sustained over 12 months from treatment completion. Conclusions: Dose-dense chemotherapy regimens for breast cancer lead to marked and sustained decreases in AMH irrespective of patient age.

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乳腺癌高剂量化疗方案与卵巢储备功能显著下降有关

目的：确定剂量密集化疗对接受乳腺癌治疗的女性卵巢储备功能的影响。患者与方法我们对因乳腺癌新诊断而接受盐酸多柔比星和环磷酰胺联合或不联合紫杉醇剂量密集化疗方案的育龄妇女进行了一项回顾性队列研究。我们比较了治疗前和治疗后的血清抗苗勒氏管激素（AMH）水平，并评估了AMH随时间的变化。结果57名患者符合纳入标准。治疗前的AMH中位数为2.9纳克/毫升，而治疗后的AMH为0.1纳克/毫升，这表明采用剂量密集疗法治疗后，AMH水平急剧下降。这种变化与年龄无关，并在治疗结束后的12个月内持续存在。结论乳腺癌剂量密集化疗方案会导致AMH显著持续下降，与患者年龄无关。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.