Influence of Gut Microbiota and its Metabolites on Progression of Metabolic Associated Fatty Liver Disease.

Q2 Medicine Chinese Medical Sciences Journal Pub Date : 2023-12-01 DOI:10.24920/004220
Yuan-Yuan Wang, Hai-Lian Lin, Ke-Lang Wang, Gen-Xiang Que, Ting Cao, La-Mei Zhu, Xia Yang, Xue-Feng Yang
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引用次数: 0

Abstract

Metabolic associated fatty liver disease (MAFLD) has become a prevalent chronic liver disease worldwide because of lifestyle and dietary changes. Gut microbiota and its metabolites have been shown to play a critical role in the pathogenesis of MAFLD. Understanding of the function of gut microbiota and its metabolites in MAFLD may help to elucidate pathological mechanisms, identify diagnostic markers, and develop drugs or probiotics for the treatment of MAFLD. Here we review the pathogenesis of MAFLD by gut microbiota and its metabolites and discuss the feasibility of treating MAFLD from the perspective of gut microbes.

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肠道微生物群及其代谢产物对代谢相关性脂肪肝进展的影响
由于生活方式和饮食习惯的改变,代谢相关性脂肪肝(MAFLD)已成为全球流行的慢性肝病。肠道微生物群及其代谢产物已被证明在代谢相关性脂肪肝的发病机制中起着至关重要的作用。了解肠道微生物群及其代谢产物在 MAFLD 中的功能有助于阐明病理机制、确定诊断标志物以及开发治疗 MAFLD 的药物或益生菌。在此,我们回顾了肠道微生物群及其代谢产物对 MAFLD 的致病机理,并从肠道微生物的角度探讨了治疗 MAFLD 的可行性。
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来源期刊
Chinese Medical Sciences Journal
Chinese Medical Sciences Journal Medicine-Medicine (all)
CiteScore
2.40
自引率
0.00%
发文量
1275
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