Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing.

IF 13.6 1区生物学 Q1 CELL BIOLOGY Protein & Cell Pub Date : 2024-04-01 DOI:10.1093/procel/pwad058

Han Chen, Mehar Monga, Qinghua Fang, Loujin Slitin, Jakob Neef, Shashank S Chepurwar, Regina Célia Mingroni Netto, Karina Lezirovitz, Alfredo Tabith, Fritz Benseler, Nils Brose, Kathrin Kusch, Carolin Wichmann, Nicola Strenzke, Barbara Vona, Julia Preobraschenski, Tobias Moser

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Ca2+与奥托费林C2E结构域的结合是毛细胞外泌和听觉所必需的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Protein & Cell CELL BIOLOGY-

CiteScore

24.00

自引率

0.90%

发文量

1029

审稿时长

6-12 weeks

期刊介绍： Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.

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