Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance.

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY RNA Biology Pub Date : 2024-01-01 Epub Date: 2023-12-19 DOI:10.1080/15476286.2023.2290769
Qingmin Zeng, Chang-Hai Liu, Javier Ampuero, Dongbo Wu, Wei Jiang, Lingyun Zhou, Hong Li, Lang Bai, Manuel Romero-Gómez, Hong Tang
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Abstract

Nonalcoholic fatty liver disease (NAFLD), which affects approximately 25% of the global population, is an urgent health issue leading to various metabolic comorbidities. Circular RNAs (circRNAs), covalently closed RNA molecules, are characterized by ubiquity, diversity, stability, and conservatism. Indeed, they participate in various biological processes via distinct mechanisms that could modify the natural history of NAFLD. In this review, we briefly introduce the biogenesis, characteristics, and biological functions of circRNAs. Furthermore, we summarize circRNAs expression profiles in NAFLD by intersecting seven sequencing data sets and describe the cellular roles of circRNAs and their potential advantages as biomarkers of NAFLD. In addition, we emphatically discuss the exosomal non-coding RNA sorting mechanisms and possible functions in recipient cells. Finally, we extensively discuss the potential application of targeting disease-related circRNAs and competing endogenous RNA networks through gain-of-function and loss-of-function approaches in targeted therapy of NAFLD.

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非酒精性脂肪肝中的环状 RNA:功能和临床意义
非酒精性脂肪肝(NAFLD)影响着全球约 25% 的人口,是一个亟待解决的健康问题,会导致各种代谢并发症。环状 RNA(circRNA)是共价封闭的 RNA 分子,具有普遍性、多样性、稳定性和保守性等特点。事实上,它们通过不同的机制参与各种生物过程,可改变非酒精性脂肪肝的自然病史。在这篇综述中,我们简要介绍了 circRNA 的生物发生、特点和生物学功能。此外,我们还通过交叉七组测序数据总结了非酒精性脂肪肝中 circRNAs 的表达谱,并描述了 circRNAs 的细胞作用及其作为非酒精性脂肪肝生物标志物的潜在优势。此外,我们还着重讨论了外泌体非编码 RNA 的分选机制以及在受体细胞中可能发挥的功能。最后,我们广泛讨论了在非酒精性脂肪肝的靶向治疗中,通过功能增益和功能缺失方法靶向疾病相关的 circRNA 和竞争性内源性 RNA 网络的潜在应用。
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来源期刊
RNA Biology
RNA Biology 生物-生化与分子生物学
CiteScore
8.60
自引率
0.00%
发文量
82
审稿时长
1 months
期刊介绍: RNA has played a central role in all cellular processes since the beginning of life: decoding the genome, regulating gene expression, mediating molecular interactions, catalyzing chemical reactions. RNA Biology, as a leading journal in the field, provides a platform for presenting and discussing cutting-edge RNA research. RNA Biology brings together a multidisciplinary community of scientists working in the areas of: Transcription and splicing Post-transcriptional regulation of gene expression Non-coding RNAs RNA localization Translation and catalysis by RNA Structural biology Bioinformatics RNA in disease and therapy
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