Anti-inflammatory activity of Atavijambira (Atalantia monophylla DC.) root and stem.

Ayu Pub Date : 2022-07-01 Epub Date: 2023-10-09 DOI:10.4103/ayu.ayu_118_21

Das Ashokkumar Nathulal, Rabinarayan Acharya, Mukesh B Nariya

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Abstract

Background: Atalantia monophylla DC. family Rutaceae, a promising drug, has multifaceted ethnomedicinal claims to treat rheumatism, arthritis, paralysis, cough, skin diseases, etc., In traditional practice, root and stem are administered to treat rheumatism and arthritis, respectively.

Aim: The aim of this study was to evaluate the anti-inflammatory activity of the root and stem of A. monophylla against carrageenan-induced acute paw edema in wistar albino rats.

Materials and methods: Shade dried root and stem were grinded separately into a fine powder (120#) by the mechanical grinder. Test drugs were prepared in Phanta (hot infusion) form and used as fresh (A. monophylla root Phanta [AMRP] and A. monophylla stem Phanta [AMSP]). Difference between the groups was statistically determined by one-way ANOVA, followed by Dunnett's multiple "t" test for unpaired data.

Results: AMSP showed a significant decrease in paw inflammation at all-time interval (P < 0.05), whereas AMRP produced nonsignificant decrease in paw inflammation at 1 h (43.53%) and 5 h (25.74%) while significant (P < 0.05) anti-inflammatory activity at 3 h (36.35%) in comparison with the normal control group.

Conclusion: The present study concluded that A. monophylla stem is having significant anti-inflammatory activity in comparison to its root when administered in Phanta form against carrageenan-induced acute inflammation in rats.

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Atavijambira (Atalantia monophylla DC.) 根和茎的抗炎活性。

背景：芸香科植物Atalantia monophylla DC.是一种很有前途的药物，具有治疗风湿病、关节炎、瘫痪、咳嗽、皮肤病等多方面的民族药用价值、目的：本研究旨在评估 A. monophylla 的根和茎对角叉菜胶诱导的急性爪水肿的抗炎活性：阴干的根和茎用机械研磨机分别研磨成细粉（120#）。试验药物以热灌肠形式制备，并作为新鲜药物使用（A. monophylla 根 Phanta [AMRP] 和 A. monophylla 茎 Phanta [AMSP]）。各组之间的差异通过单因素方差分析进行统计，对非配对数据进行邓尼特多重 "t "检验：结果：与正常对照组相比，AMSP 在所有时间间隔内都能明显减轻爪部炎症（P < 0.05），而 AMRP 在 1 小时（43.53%）和 5 小时（25.74%）内减轻爪部炎症的效果不明显，但在 3 小时（36.35%）内具有明显的抗炎活性（P < 0.05）：本研究得出的结论是，与根相比，A. monophylla 的茎在以 Phanta 形式给药时对角叉菜胶诱导的大鼠急性炎症具有显著的抗炎活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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