International Trends in Adverse Drug Event-Related Mortality from 2001 to 2019: An Analysis of the World Health Organization Mortality Database from 54 Countries.

IF 4 2区 医学 Q1 PHARMACOLOGY & PHARMACY Drug Safety Pub Date : 2024-03-01 Epub Date: 2023-12-22 DOI:10.1007/s40264-023-01387-0
Toshihiro Koyama, Shunya Iinuma, Michio Yamamoto, Takahiro Niimura, Yuka Osaki, Sayoko Nishimura, Ko Harada, Yoshito Zamami, Hideharu Hagiya
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Abstract

Background and objective: Adverse drug events (ADEs) are becoming a significant public health issue. However, reports on ADE-related mortality are limited to national-level evaluations. Therefore, we aimed to reveal overall trends in ADE-related mortality across the 21st century on an international level.

Methods: This observational study analysed long-term trends in ADE-related mortality rates from 2001 to 2019 using the World Health Organization Mortality Database. The rates were analysed according to sex, age and region. North America, Latin America and the Caribbean, Western Europe, Eastern Europe and Western Pacific regions were assessed. Fifty-four countries were included with four-character International Statistical Classification of Disease and Related Health Problems, Tenth Revision codes in the database, population data in the World Population Prospects 2019 report, mortality data in more than half of the study period, and high-quality or medium-quality death registration data. A locally weighted regression curve was used to show international trends in age-standardised rates.

Results: The global ADE-related mortality rate per 100,000 population increased from 2.05 (95% confidence interval 0.92-3.18) in 2001 to 6.86 (95% confidence interval 5.76-7.95) in 2019. Mortality rates were higher among men than among women, especially in those aged 20-50 years. The population aged ≥ 75 years had higher ADE-related mortality rates than the younger population. North America had the highest mortality rate among the five regions. The global ADE-related mortality rate increased by approximately 3.3-fold from 2001 to 2019.

Conclusions: The burden of ADEs has increased internationally with rising mortality rates. Establishing pharmacovigilance systems can facilitate efforts to reduce ADE-related mortality rates globally.

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2001 年至 2019 年与药物不良事件相关的死亡率的国际趋势:对世界卫生组织 54 个国家死亡率数据库的分析》(International Trends in Adverse Drug Event-Related Mortality from 2001 to 2019: An Analysis of the World Health Organization Mortality Database from 54 Countries)。
背景和目的:药物不良事件(ADEs)正成为一个重要的公共卫生问题。然而,有关 ADE 相关死亡率的报告仅限于国家层面的评估。因此,我们旨在从国际层面揭示 21 世纪 ADE 相关死亡率的总体趋势:这项观察性研究利用世界卫生组织死亡率数据库分析了 2001 年至 2019 年 ADE 相关死亡率的长期趋势。根据性别、年龄和地区对死亡率进行了分析。评估对象包括北美、拉丁美洲和加勒比海地区、西欧、东欧和西太平洋地区。有54个国家被纳入了评估范围,这些国家在数据库中拥有《国际疾病和相关健康问题统计分类第十次修订版》的四字符代码、《2019年世界人口展望》报告中的人口数据、研究期间一半以上的死亡率数据以及高质量或中等质量的死亡登记数据。采用局部加权回归曲线来显示年龄标准化死亡率的国际趋势:全球每 10 万人 ADE 相关死亡率从 2001 年的 2.05(95% 置信区间为 0.92-3.18)上升至 2019 年的 6.86(95% 置信区间为 5.76-7.95)。男性死亡率高于女性,尤其是在 20-50 岁人群中。年龄≥75岁人群的ADE相关死亡率高于年轻人群。在五个地区中,北美洲的死亡率最高。从2001年到2019年,全球ADE相关死亡率增加了约3.3倍:结论:随着死亡率的上升,ADEs 的负担在全球范围内加重。建立药物警戒系统有助于降低全球 ADE 相关死亡率。
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来源期刊
Drug Safety
Drug Safety 医学-毒理学
CiteScore
7.60
自引率
7.10%
发文量
112
审稿时长
6-12 weeks
期刊介绍: Drug Safety is the official journal of the International Society of Pharmacovigilance. The journal includes: Overviews of contentious or emerging issues. Comprehensive narrative reviews that provide an authoritative source of information on epidemiology, clinical features, prevention and management of adverse effects of individual drugs and drug classes. In-depth benefit-risk assessment of adverse effect and efficacy data for a drug in a defined therapeutic area. Systematic reviews (with or without meta-analyses) that collate empirical evidence to answer a specific research question, using explicit, systematic methods as outlined by the PRISMA statement. Original research articles reporting the results of well-designed studies in disciplines such as pharmacoepidemiology, pharmacovigilance, pharmacology and toxicology, and pharmacogenomics. Editorials and commentaries on topical issues. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in Drug Safety Drugs may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.
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