SARS-CoV-2 humoral immune response in patients with cardiovascular risk factors: The COmmunity Cohort Study.

IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Medwave Pub Date : 2023-12-20 DOI:10.5867/medwave.2023.11.2787
Vivienne C Bachelet, Ignacio Silva-Ayarza, María S Navarrete
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Abstract

Based on the recommendations of the Vaccine Advisory Committee and the National Immunization Program, Chile implemented an early vaccination process of the population with vaccines from different laboratories. The study of neutralizing antibody levels in different population subgroups contributes to the establishment of correlates of protection against SARS-CoV-2 infection. In 2022 and 2023 we set up a community cohort of 914 adults with cardiovascular risk factors. In this cohort we are measuring the humoral immune response to exposure to SARS-CoV-2 antigens, either by vaccines or infection, as well as the incidence of COVID-19 and other adverse events. This cohort, which we call The COmmunity Cohort, is providing us with valuable information on the levels of neutralizing antibodies in these individuals and their degree of protection against COVID-19.

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有心血管风险因素患者的 SARS-CoV-2 体液免疫反应:社区队列研究
根据疫苗咨询委员会和国家免疫计划的建议,智利使用来自不同实验室的疫苗对人口进行了早期接种。对不同人群亚群中的中和抗体水平进行研究,有助于建立预防 SARS-CoV-2 感染的相关机制。2022 年和 2023 年,我们建立了一个由 914 名具有心血管风险因素的成年人组成的社区队列。在这个队列中,我们将测量通过疫苗或感染接触 SARS-CoV-2 抗原后的体液免疫反应,以及 COVID-19 和其他不良事件的发生率。我们称之为 "社区队列",它为我们提供了有关这些人体内中和抗体水平及其对 COVID-19 保护程度的宝贵信息。
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来源期刊
Medwave
Medwave MEDICINE, GENERAL & INTERNAL-
CiteScore
2.60
自引率
8.30%
发文量
50
审稿时长
12 weeks
期刊介绍: Medwave is a peer-reviewed, biomedical and public health journal. Since its foundation in 2001 (Volume 1) it has always been an online only, open access publication that does not charge subscription or reader fees. Since January 2011 (Volume 11, Number 1), all articles are peer-reviewed. Without losing sight of the importance of evidence-based approach and methodological soundness, the journal accepts for publication articles that focus on providing updates for clinical practice, review and analysis articles on topics such as ethics, public health and health policy; clinical, social and economic health determinants; clinical and health research findings from all of the major disciplines of medicine, medical science and public health. The journal does not publish basic science manuscripts or experiments conducted on animals. Until March 2013, Medwave was publishing 11-12 numbers a year. Each issue would be posted on the homepage on day 1 of each month, except for Chile’s summer holiday when the issue would cover two months. Starting from April 2013, Medwave adopted the continuous mode of publication, which means that the copyedited accepted articles are posted on the journal’s homepage as they are ready. They are then collated in the respective issue and included in the Past Issues section.
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