Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice.

IF 3.4 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Molecular medicine reports Pub Date : 2024-02-01 Epub Date: 2023-12-22 DOI:10.3892/mmr.2023.13153
Tae-Young Gil, Junkyu Park, Yea-Jin Park, Hyo-Jung Kim, Divina C Cominguez, Hyo-Jin An
{"title":"Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice.","authors":"Tae-Young Gil, Junkyu Park, Yea-Jin Park, Hyo-Jung Kim, Divina C Cominguez, Hyo-Jin An","doi":"10.3892/mmr.2023.13153","DOIUrl":null,"url":null,"abstract":"<p><p>Drynaria rhizome is a herbal medicine used for strengthening bones and treating bone diseases in East Asia. Although obesity is considered to benefit bone formation, it has been revealed that visceral fat accumulation can promote osteoporosis. Given the complex relationship between bone metabolism and obesity, bone‑strengthening medicines should be evaluated while considering the effects of obesity. The present study investigated the effects of Drynaria rhizome extract (DRE) on high‑fat diet (HFD)‑induced obese mice. DRE was supplemented with the HFD. Body weight, food intake, the expression levels of lipogenesis transcription factors, including sterol regulatory element binding protein (SREBP)‑1, peroxisome proliferator‑activated receptor (PPAR)‑γ and adenosine monophosphate‑activated protein kinase (AMPK)‑α, and AMPK activation were evaluated. Mice fed DRE and a HFD exhibited reduced body weight without differences in food intake compared with those in the HFD group. Furthermore, DRE; upregulated AMPK‑α of epididymal one; down‑regulated SREBP‑1 and PPAR‑γ, as determined using western blotting and quantitative polymerase chain reaction, respectively. Decreased lipid accumulation were observed in both fat pad and liver of HFD‑fed mice, which were suppressed by DRE treatment. These results demonstrated the potential of DRE as a dietary natural product for strengthening bones and managing obesity.</p>","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"29 2","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10784730/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular medicine reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3892/mmr.2023.13153","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/22 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

Abstract

Drynaria rhizome is a herbal medicine used for strengthening bones and treating bone diseases in East Asia. Although obesity is considered to benefit bone formation, it has been revealed that visceral fat accumulation can promote osteoporosis. Given the complex relationship between bone metabolism and obesity, bone‑strengthening medicines should be evaluated while considering the effects of obesity. The present study investigated the effects of Drynaria rhizome extract (DRE) on high‑fat diet (HFD)‑induced obese mice. DRE was supplemented with the HFD. Body weight, food intake, the expression levels of lipogenesis transcription factors, including sterol regulatory element binding protein (SREBP)‑1, peroxisome proliferator‑activated receptor (PPAR)‑γ and adenosine monophosphate‑activated protein kinase (AMPK)‑α, and AMPK activation were evaluated. Mice fed DRE and a HFD exhibited reduced body weight without differences in food intake compared with those in the HFD group. Furthermore, DRE; upregulated AMPK‑α of epididymal one; down‑regulated SREBP‑1 and PPAR‑γ, as determined using western blotting and quantitative polymerase chain reaction, respectively. Decreased lipid accumulation were observed in both fat pad and liver of HFD‑fed mice, which were suppressed by DRE treatment. These results demonstrated the potential of DRE as a dietary natural product for strengthening bones and managing obesity.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
旱莲草根茎水提取物能缓解高脂饮食引起的小鼠肥胖症。
旱金莲根茎在东亚是一种用于强化骨骼和治疗骨病的草药。虽然肥胖被认为有利于骨骼的形成,但研究发现内脏脂肪堆积会促进骨质疏松。鉴于骨代谢与肥胖之间的复杂关系,在评估健骨药物时应同时考虑肥胖的影响。本研究调查了旱莲草根茎提取物(DRE)对高脂饮食(HFD)诱导的肥胖小鼠的影响。在高脂饮食中添加 DRE。对体重、食物摄入量、脂肪生成转录因子(包括固醇调节元件结合蛋白(SREBP)-1、过氧化物酶体增殖激活受体(PPAR)-γ和单磷酸腺苷激活蛋白激酶(AMPK)-α)的表达水平以及AMPK激活情况进行了评估。与高饱和脂肪酸组的小鼠相比,喂食 DRE 和高饱和脂肪酸组的小鼠体重下降,但食物摄入量没有差异。此外,使用 Western 印迹和定量聚合酶链反应分别测定,DRE 上调了附睾中的 AMPK-α,下调了 SREBP-1 和 PPAR-γ。高密度脂蛋白胆固醇喂养小鼠的脂肪垫和肝脏中均观察到脂质积累减少,而 DRE 治疗可抑制脂质积累。这些结果证明了 DRE 作为一种膳食天然产品在强化骨骼和控制肥胖方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Molecular medicine reports
Molecular medicine reports 医学-病理学
CiteScore
7.60
自引率
0.00%
发文量
321
审稿时长
1.5 months
期刊介绍: Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
期刊最新文献
[Corrigendum] MicroRNA‑378 enhances migration and invasion in cervical cancer by directly targeting autophagy‑related protein 12. [Retracted] Carnosol inhibits osteoclastogenesis in vivo and in vitro by blocking the RANKL‑induced NF‑κB signaling pathway. Epigenetic regulatory mechanism of macrophage polarization in diabetic wound healing (Review). Orphan nuclear receptor NR4A1 regulates both osteoblastogenesis and adipogenesis in human mesenchymal stem cells. [Retracted] Molecular mechanism of atractylon in the invasion and migration of hepatic cancer cells based on high‑throughput sequencing.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1