Global, regional and national burden of CKD in children and adolescents from 1990 to 2019.

IF 4.8 2区医学 Q1 TRANSPLANTATION Nephrology Dialysis Transplantation Pub Date : 2024-07-31 DOI:10.1093/ndt/gfad269

Wen-Man Zhao, Xun-Liang Li, Rui Shi, Yuyu Zhu, Zhi-Juan Wang, Xue-Rong Wang, Hai-Feng Pan, De-Guang Wang

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Abstract

Background: Chronic kidney disease(CKD) is one of the most prevalent non-communicable health concerns in children and adolescents worldwide; however, data on its incidence, prevalence, disability-adjusted life years (DALYs) and trends in the population are limited. We aimed to assess the global, regional and national trends in CKD burden in children and adolescents.

Methods: In this trend analysis based on the 2019 Global Diseases, Injuries, and Risk Factors Study, CKD incidence, prevalence and DALYs rates per 100 000 population for children and adolescents were reported at the global, regional and national levels, as well as the average annual percentage change (AAPC). These global trends were analyzed by age, sex, region and socio-demographic index (SDI).

Results: Globally, the overall incidence of CKD (all stages including kidney replacement therapy) in children and adolescents showed an increasing trend [AAPC 0.44 (95% confidence interval 0.36-0.52)] between 1990 and 2019. Similarly, the overall prevalence of CKD also showed an upward trend [AAPC 0.46 (0.42-0.51)]. However, the DALYs of CKD showed a continuous decreasing trend [AAPC -1.18 (-1.37 to -0.99)]. The population aged 15-19 years had the largest CKD incidence increase during this period. The largest increase in age-standardized incidence rate (ASIR) was in middle SDI countries [AAPC 0.56 (0.45-0.67)]. The relationship between the ASIR and SDI showed an inverse U-shaped correlation while the relationship between the age-standardized DALYs rate (ASDR) and SDI showed an inverse trend with SDI. Among adolescents (15-19 years), the ASIR continued to increase for five causes of CKD, owing to type 2 diabetes mellitus and hypertension. Most of the disease burden was concentrated in countries with a lower SDI. Andean Latin America and Central Latin America showed the largest increases in CKD ASIR between 1990 and 2019.

Conclusion: The burden of CKD in children and adolescents has increased worldwide, especially in regions and countries with a lower SDI.

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1990 至 2019 年全球、地区和国家的儿童和青少年慢性肾脏病负担。

背景和目的：慢性肾脏病是全球儿童和青少年最普遍的非传染性健康问题之一；然而，有关其发病率、流行率、残疾调整生命年（DALYs）和人口趋势的数据却很有限。我们旨在评估儿童和青少年慢性肾脏病负担的全球、地区和国家趋势：在这项基于《2019 年全球疾病、伤害和风险因素研究》的趋势分析中，报告了全球、地区和国家层面的儿童和青少年 CKD 发病率、流行率和每 10 万人口的 DALYs 率，以及平均年百分比变化 (AAPC)。这些全球趋势按年龄、性别、地区和社会人口指数（SDI）进行了分析：结果：1990 年至 2019 年期间，全球儿童和青少年慢性肾脏病（所有阶段，包括 KRT）的总发病率呈上升趋势（AAPC 0.44 [95% CI 0.36-0.52]）。同样，CKD 的总体患病率也呈上升趋势（AAPC 0.46 [95% CI 0.42-0.51]）。然而，慢性肾功能衰竭的残疾调整寿命年数呈持续下降趋势（AAPC-1.18[-1.37--0.99]）。在此期间，15-19 岁人群的慢性肾脏病发病率增幅最大。中等 SDI 国家的年龄标准化发病率（ASIR）增幅最大（AAPC 0.56 [0.45-0.67]）。年龄标准化发病率与 SDI 之间的关系呈反 U 型，而年龄标准化残疾调整寿命年数率（ASDR）与 SDI 之间的关系则与 SDI 呈反向趋势。在青少年（15-19 岁）中，由于 2 型糖尿病和高血压，导致慢性肾脏病的五种病因的 ASIR 持续上升。大部分疾病负担集中在 SDI 较低的国家。1990年至2019年期间，拉丁美洲安第斯地区和拉丁美洲中部地区的慢性肾脏病ASIR增幅最大：全球儿童和青少年的慢性肾脏病负担加重，特别是在SDI较低的地区和国家。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephrology Dialysis Transplantation 医学-泌尿学与肾脏学

CiteScore

10.10

自引率

4.90%

发文量

1431

审稿时长

1.7 months

期刊介绍： Nephrology Dialysis Transplantation (ndt) is the leading nephrology journal in Europe and renowned worldwide, devoted to original clinical and laboratory research in nephrology, dialysis and transplantation. ndt is an official journal of the [ERA-EDTA](http://www.era-edta.org/) (European Renal Association-European Dialysis and Transplant Association). Published monthly, the journal provides an essential resource for researchers and clinicians throughout the world. All research articles in this journal have undergone peer review. Print ISSN: 0931-0509.