Pro-inflammatory and pro-oxidant diets are associated with increased odds of cataracts and serum biomarkers of inflammation and oxidative stress: Hospital-based case-control study

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Human Nutrition and Metabolism Pub Date : 2023-12-19 DOI:10.1016/j.hnm.2023.200234
Farhad Vahid , Diana Rahmani
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Abstract

Background

Oxidative stress and inflammation play an important role in cataracts' causal network. In this study, we used the Dietary Inflammatory Index (DII) and Dietary Antioxidant Index (DAI) to comprehensively examine the nutritional status related to inflammation and oxidative stress and investigate their association with the odds of cataracts. We hypothesize that higher DII scores (a pro-inflammatory diet) and lower DAI (a pro-oxidant diet) are associated with related serum biomarkers and increase the odds of cataracts.

Methods

The study included 263 patients with cataracts and 326 healthy controls. A valid 168-item food frequency questionnaire (FFQ) evaluated the participants' dietary intake over the past year. DII and DAI were calculated based on FFQ, and blood/serum indicators, e.g., hs-CRP, TNF-a, etc., were extracted from patients' records.

Results

Based on the multivariable linear regression models, there was a significant association between DII and hs-CRP (Beta = 0.095, CI95 %: 0.001–0.189) and between DAI and TNF-a (Beta = 0.494, CI95 %: 0.121–0.866) and LDL-C (Beta = 1.037, CI95 %: 0.159–1.915). In addition, in logistic regression models, after adjusting for multiple confounders, there was a significant association between DII (continuous variable) (OR = 1.27, CI95 %: 1.08–1.50) and DAI (continuous variable) (OR = 0.93, CI95 %: 0.87–0.99) and odds of cataracts.

Conclusion

This study confirms the association between pro-inflammatory and pro-oxidant diets, as indicated by higher DII scores and lower DAI, with serum biomarkers of inflammation and oxidative stress. Our study supports the notion that dietary interventions targeting inflammation and oxidative stress may have a potential role in preventing or delaying the onset of cataracts.

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促炎症和促氧化饮食与白内障发病几率增加以及炎症和氧化应激的血清生物标志物有关:基于医院的病例对照研究
背景氧化应激和炎症在白内障的病因网络中扮演着重要角色。在本研究中,我们采用膳食炎症指数(DII)和膳食抗氧化指数(DAI)来全面检测与炎症和氧化应激相关的营养状况,并研究它们与白内障发病几率的关系。我们假设,较高的 DII 分数(促炎症饮食)和较低的 DAI(促氧化饮食)与相关的血清生物标志物有关,并会增加白内障的发病几率。有效的 168 项食物频率问卷(FFQ)评估了参与者过去一年的饮食摄入量。根据 FFQ 计算 DII 和 DAI,并从患者记录中提取血液/血清指标,如 hs-CRP、TNF-a 等、结果基于多变量线性回归模型,DII与hs-CRP(Beta = 0.095,CI95 %:0.001-0.189)、DAI与TNF-a(Beta = 0.494,CI95 %:0.121-0.866)和LDL-C(Beta = 1.037,CI95 %:0.159-1.915)之间存在显著关联。此外,在逻辑回归模型中,调整多种混杂因素后,DII(连续变量)(OR = 1.27,CI95 %:1.08-1.50)和 DAI(连续变量)(OR = 0.93,CI95 %:0.结论本研究证实了促炎症和促氧化饮食(如较高的 DII 分数和较低的 DAI)与炎症和氧化应激的血清生物标志物之间的关联。我们的研究支持这样一种观点,即针对炎症和氧化应激的饮食干预措施可能在预防或推迟白内障发病方面发挥潜在作用。
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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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