Rapid-release reversible bonding of PMMA-based microfluidic devices with PBMA coating

IF 3 4区医学 Q3 ENGINEERING, BIOMEDICAL Biomedical Microdevices Pub Date : 2023-12-23 DOI:10.1007/s10544-023-00690-y

Yusheng Li, Fan Xu, Jing liu, Qi Zhang, Yiqiang Fan

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Abstract

PMMA-based microfluidics have been widely used in various applications in biological and chemical fields. In the fabrication process of PMMA-based microfluidics, the substrate and cover plate usually need to be bonded to enclose the microchannel. The bonding process could be permanent or reversible. In some application scenarios, reversible bonding is needed to retrieve the samples inside the channel or reuse the chip. Current reversible bonding methods for PMMA-based microfluidics usually have drawbacks on bonding strength and contaminations from the adhesives used in the bonding process. In this study, a new approach is proposed for the reversible bonding of PMMA-based microfluidics, a layer of PBMA (with a very similar structure to PMMA) was coated on the surface of PMMA and then use the thermal fusion method to achieve the bonding with a high bonding strength, a tensile bonding strength of around 0.8 MPa was achieved. For debond process, a rapid temperature drop will trigger the immediate release of the bonding within several seconds. Detailed bonding strength measurement and biocompatibility tests were also conducted in this study. The proposed bonding method could have wide application potential in the fabrication of PMMA-based microfluidics.

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基于 PMMA 的微流控设备与 PBMA 涂层的快速释放可逆粘接。

基于 PMMA 的微流控技术已广泛应用于生物和化学领域的各种应用。在基于 PMMA 的微流控芯片的制造过程中，通常需要将基板和盖板粘合在一起，以封闭微通道。粘合过程可以是永久性的，也可以是可逆的。在某些应用场景中，需要使用可逆键合来取回通道内的样品或重复使用芯片。目前用于基于 PMMA 的微流控芯片的可逆键合方法通常在键合强度和键合过程中使用的粘合剂污染方面存在缺陷。本研究为基于 PMMA 的微流控芯片的可逆键合提出了一种新方法，即在 PMMA 表面涂上一层 PBMA（与 PMMA 的结构非常相似），然后使用热熔方法实现高键合强度的键合，达到约 0.8 兆帕的拉伸键合强度。在脱粘过程中，温度的急剧下降会在几秒钟内触发粘合剂的立即释放。本研究还进行了详细的粘合强度测量和生物相容性测试。所提出的粘合方法在基于 PMMA 的微流控芯片制造中具有广泛的应用潜力。

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来源期刊

Biomedical Microdevices 工程技术-工程：生物医学

CiteScore

6.90

自引率

3.60%

发文量

审稿时长

6 months

期刊介绍： Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.