Evaluation of biological agents and small-molecule drugs in the treatment of pruritus caused by various dermatoses

Abstract

Pruritus is a common symptom of many skin diseases that seriously affects the physical and mental health of patients. In clinical practice, many patients have pruritus that cannot be effectively improved by conventional treatments. Recent studies have found that pruritus is related to a variety of cells and cytokines that are expected to become therapeutic targets. Biological agents and new small-molecule drugs have shown good prospects in the treatment of pruritus. We searched the PubMed, Embase, Cochrane Library, and other databases for clinical trials and case reports of biological agents and small-molecule drugs in the treatment of pruritus, and reviewed the relevant content. This review provides new ideas for the improvement of pruritus and quality of life of patients with skin diseases.