Pub Date : 2024-07-11DOI: 10.1097/jd9.0000000000000394
Xiu-Feng Liu, Man-Chang Yu
To assess the impact of 30% supramolecular salicylic acid (SSA) combined with ultra-pulse carbon dioxide (CO2) fractional laser therapy on facial atrophic acne scars. This retrospective study included patients with atrophic acne scars treated from June 2020 to June 2022. The patients were divided into the combination group (SSA combined with ultra-pulse CO2 fractional laser therapy) and the laser group (ultra-pulse CO2 fractional laser therapy alone). Four treatment sessions were conducted for each group. Follow-up visits were performed every 2 months after each treatment and included assessments of the Échelle d'Évaluation clinique des cicatrices d'acné (ECCA) score, effective rate, and visual analogue scale score. The combination and laser groups comprised 72 and 61 patients, respectively. There were no significant differences in sex, age, or baseline ECCA score between the two groups. The effective rate (95.8% vs. 67.2%, P < 0.001) was higher and the pain scores (during and after the intervention) were lower in the combination group than in the laser group (P < 0.001). The severity of erythema, edema, and crusting was milder in the combination group (P < 0.001). The proportion of highly satisfied patients was higher (73.6% vs. 31.2%, P < 0.001) and the Dermatology Life Quality Index showed greater improvement (0.15 ± 0.40 vs. 1.39 ± 1.53, P < 0.001) in the combination group than in the laser group. The combination of ultra-pulse CO2 fractional laser therapy and 30% supramolecular SSA had improved efficacy in treating facial atrophic acne scars without increasing pain or inducing adverse reactions.
{"title":"Impact of 30% supramolecular salicylic acid combined with ultra-pulse carbon dioxide fractional laser therapy on facial atrophic acne scars","authors":"Xiu-Feng Liu, Man-Chang Yu","doi":"10.1097/jd9.0000000000000394","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000394","url":null,"abstract":"\u0000 \u0000 To assess the impact of 30% supramolecular salicylic acid (SSA) combined with ultra-pulse carbon dioxide (CO2) fractional laser therapy on facial atrophic acne scars.\u0000 \u0000 \u0000 \u0000 This retrospective study included patients with atrophic acne scars treated from June 2020 to June 2022. The patients were divided into the combination group (SSA combined with ultra-pulse CO2 fractional laser therapy) and the laser group (ultra-pulse CO2 fractional laser therapy alone). Four treatment sessions were conducted for each group. Follow-up visits were performed every 2 months after each treatment and included assessments of the Échelle d'Évaluation clinique des cicatrices d'acné (ECCA) score, effective rate, and visual analogue scale score.\u0000 \u0000 \u0000 \u0000 The combination and laser groups comprised 72 and 61 patients, respectively. There were no significant differences in sex, age, or baseline ECCA score between the two groups. The effective rate (95.8% vs. 67.2%, P < 0.001) was higher and the pain scores (during and after the intervention) were lower in the combination group than in the laser group (P < 0.001). The severity of erythema, edema, and crusting was milder in the combination group (P < 0.001). The proportion of highly satisfied patients was higher (73.6% vs. 31.2%, P < 0.001) and the Dermatology Life Quality Index showed greater improvement (0.15 ± 0.40 vs. 1.39 ± 1.53, P < 0.001) in the combination group than in the laser group.\u0000 \u0000 \u0000 \u0000 The combination of ultra-pulse CO2 fractional laser therapy and 30% supramolecular SSA had improved efficacy in treating facial atrophic acne scars without increasing pain or inducing adverse reactions.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141656846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-08DOI: 10.1097/jd9.0000000000000396
Mariana Muzzolon, Mariana A Pasa Morgan, R. Imoto, Vânia O de Carvalho
The success of managing atopic dermatitis (AD) largely depends on patient adherence to treatment. Achieving adherence requires more than knowledge transfer; it also requires a change in patients’ health behavior. Therefore, we conducted this study to develop and validate the content of health games for the pediatric population with AD. This study focused on developing and validating the content of health games about AD. Among these were the book Oli e o Grande Desafio da Coceira™ (“Oli and the Great Itching Challenge”) and the games Dermatrilha™ (“Dermatrail”) and Caixinha Surpresa da Dermatite™ (“Dermatitis Surprise Box”). The instrument development process consisted of five stages: planning of the instruments, development of the instruments, development of content validation questionnaires, evaluation by an expert committee, and a pre-test with the target audience. The expert committee comprised 20 professionals: 5 pediatric dermatologists, 5 hospital psychologists, 5 illustrators/designers, and 5 early childhood education teachers. The target audience comprised 25 children with AD aged 5 to 12 years. The content validity index was 0.94 in the evaluation by the expert committee and 0.95 in the evaluation by the target audience. Among the games, the general content validity index was 0.95 among the members of the expert committee and 0.92 among the target audience, being higher than 0.80 for all items. The health games evaluated in this study are useful psychoeducational tools with high content validity for use in the therapeutic education of children with AD.
特应性皮炎（AD）的治疗成功与否在很大程度上取决于患者是否坚持治疗。要做到坚持治疗，不仅需要知识的传授，还需要患者健康行为的改变。因此，我们开展了这项研究，以开发和验证针对儿童特应性皮炎患者的健康游戏内容。 本研究的重点是开发和验证有关注意力缺失症的健康游戏内容。这些游戏包括《Oli e o Grande Desafio da Coceira™》（《Oli 和瘙痒大挑战》）一书以及游戏 Dermatrilha™（《Dermatrail》）和 Caixinha Surpresa da Dermatite™（《皮炎惊喜盒》）。工具开发过程包括五个阶段：工具规划、工具开发、内容验证问卷开发、专家委员会评估和目标受众预测试。 专家委员会由 20 位专业人士组成：专家委员会由 20 名专业人士组成：5 名儿科皮肤科医生、5 名医院心理学家、5 名插画家/设计师和 5 名幼儿教育教师。目标受众包括 25 名 5 至 12 岁患有注意力缺失症的儿童。在专家委员会的评估中，内容效度指数为 0.94，在目标受众的评估中，内容效度指数为 0.95。在游戏中，专家委员会成员的一般内容效度指数为 0.95，目标受众的一般内容效度指数为 0.92，所有项目的内容效度指数均高于 0.80。 本研究评估的健康游戏是有用的心理教育工具，其内容效度高，可用于注意力缺失症儿童的治疗教育。
{"title":"Design and Content Validity of Health Games for children with Atopic Dermatitis","authors":"Mariana Muzzolon, Mariana A Pasa Morgan, R. Imoto, Vânia O de Carvalho","doi":"10.1097/jd9.0000000000000396","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000396","url":null,"abstract":"\u0000 \u0000 The success of managing atopic dermatitis (AD) largely depends on patient adherence to treatment. Achieving adherence requires more than knowledge transfer; it also requires a change in patients’ health behavior. Therefore, we conducted this study to develop and validate the content of health games for the pediatric population with AD.\u0000 \u0000 \u0000 \u0000 This study focused on developing and validating the content of health games about AD. Among these were the book Oli e o Grande Desafio da Coceira™ (“Oli and the Great Itching Challenge”) and the games Dermatrilha™ (“Dermatrail”) and Caixinha Surpresa da Dermatite™ (“Dermatitis Surprise Box”). The instrument development process consisted of five stages: planning of the instruments, development of the instruments, development of content validation questionnaires, evaluation by an expert committee, and a pre-test with the target audience.\u0000 \u0000 \u0000 \u0000 The expert committee comprised 20 professionals: 5 pediatric dermatologists, 5 hospital psychologists, 5 illustrators/designers, and 5 early childhood education teachers. The target audience comprised 25 children with AD aged 5 to 12 years. The content validity index was 0.94 in the evaluation by the expert committee and 0.95 in the evaluation by the target audience. Among the games, the general content validity index was 0.95 among the members of the expert committee and 0.92 among the target audience, being higher than 0.80 for all items.\u0000 \u0000 \u0000 \u0000 The health games evaluated in this study are useful psychoeducational tools with high content validity for use in the therapeutic education of children with AD.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N6-methyladenosine (m6A) modification and cuproptosis play essential roles in the pathogenesis of various malignant tumors. However, the predictive role of m6A regulators and cuproptosis-related genes in cutaneous melanoma (CM) remains unclear. In this study, the aim was not only to explore the role of m6A modification in CM, but also to investigate the differential expression of cuproptosis-related genes in different risk group. We obtained transcriptome data from the XENA and GTEx databases. Univariate Cox regression analysis was performed to investigate the relationship between m6A-related genes and the outcomes of CM. LASSO regression analysis was utilized to construct a risk model. Moreover, we analyzed immune cell infiltration using CIBERSORT algorithms. Finally, we evaluated the expression levels of cuproptosis-related genes in CM samples and performed RT-qPCR to validate the expression of cuproptosis-associated genes in melanoma cells after YTHDF3 knockdown. All m6A-related genes differed in melanoma tissues and normal tissues and a prognostic signature was developed. Immune infiltration revealed that low-risk group patients had a higher level of CD8 + T cells, memory activated CD4 + T cells, activated NK cells and M1 Macrophages than high-risk group (P<0.05). Moreover, the cuproptosis-related genes MTF-1, PDHB and FDX1 were significantly negatively associated with risk score (P=0.0007, P=0.0057 and P=0.04, respectively). We also found that downregulation YTHDF3 in melanoma cells affected the expression of cuproptosis-related genes. (P<0.01 and P<0.05). Our study demonstrated the prognostic value of m6A-related genes and cuproptosis-related genes in CM, providing new predictive models and potential therapeutic targets for CM.
{"title":"Prognosis and immune infiltration analysis of m6A RNA methylation regulators in cutaneous melanoma and differential analysis with cuproptosis related genes","authors":"Cui-cui Tian, Hao-ze Shi, Cong-cong Zhang, Yingjie Kong, Hao Chen","doi":"10.1097/jd9.0000000000000387","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000387","url":null,"abstract":"\u0000 \u0000 N6-methyladenosine (m6A) modification and cuproptosis play essential roles in the pathogenesis of various malignant tumors. However, the predictive role of m6A regulators and cuproptosis-related genes in cutaneous melanoma (CM) remains unclear. In this study, the aim was not only to explore the role of m6A modification in CM, but also to investigate the differential expression of cuproptosis-related genes in different risk group.\u0000 \u0000 \u0000 \u0000 We obtained transcriptome data from the XENA and GTEx databases. Univariate Cox regression analysis was performed to investigate the relationship between m6A-related genes and the outcomes of CM. LASSO regression analysis was utilized to construct a risk model. Moreover, we analyzed immune cell infiltration using CIBERSORT algorithms. Finally, we evaluated the expression levels of cuproptosis-related genes in CM samples and performed RT-qPCR to validate the expression of cuproptosis-associated genes in melanoma cells after YTHDF3 knockdown.\u0000 \u0000 \u0000 \u0000 All m6A-related genes differed in melanoma tissues and normal tissues and a prognostic signature was developed. Immune infiltration revealed that low-risk group patients had a higher level of CD8 + T cells, memory activated CD4 + T cells, activated NK cells and M1 Macrophages than high-risk group (P<0.05). Moreover, the cuproptosis-related genes MTF-1, PDHB and FDX1 were significantly negatively associated with risk score (P=0.0007, P=0.0057 and P=0.04, respectively). We also found that downregulation YTHDF3 in melanoma cells affected the expression of cuproptosis-related genes. (P<0.01 and P<0.05).\u0000 \u0000 \u0000 \u0000 Our study demonstrated the prognostic value of m6A-related genes and cuproptosis-related genes in CM, providing new predictive models and potential therapeutic targets for CM.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141272055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-09DOI: 10.1097/jd9.0000000000000386
Si-Ning Wang, Rui-Li Zhang
The ultrastructure of Treponema pallidum, the causative pathogen of syphilis, remains unclarified because of the difficulty of long-term culture in vitro. However, research on the ultrastructure of T. pallidum has made great progress in recent years with the success of long-term culture of T. pallidum in vitro and the development of gene sequencing technology and electron microscopy. This review summarizes the research progress on the ultrastructure of T. pallidum.
{"title":"Research progress on ultrastructure of Treponema pallidum subspecies pallidum","authors":"Si-Ning Wang, Rui-Li Zhang","doi":"10.1097/jd9.0000000000000386","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000386","url":null,"abstract":"The ultrastructure of Treponema pallidum, the causative pathogen of syphilis, remains unclarified because of the difficulty of long-term culture in vitro. However, research on the ultrastructure of T. pallidum has made great progress in recent years with the success of long-term culture of T. pallidum in vitro and the development of gene sequencing technology and electron microscopy. This review summarizes the research progress on the ultrastructure of T. pallidum.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140995870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.1097/jd9.0000000000000383
Hui-Hui Wu, Hang Li, Juan-Hua Liu, Lu-Li Song, D. Luo, Yu-Kun Zhao
We retrospectively reviewed the medical records of patients with hand-foot-and-mouth disease (HFMD) and varicella treated in a general hospital in Guangzhou, China between 2017 and 2023 to evaluate the effect of the coronavirus disease 2019 (COVID-19) on the epidemiology of HFMD and varicella in Guangzhou. The epidemiological characteristics of HFMD and varicella before (2017–2019), during (2020–2022), and after (2023) the pandemic were compared. In total, 1731 cases of HFMD and 1043 cases of varicella were reported before the COVID-19 pandemic (2017–2019), with average reporting rates of 0.08% and 0.05%, respectively. During the COVID-19 pandemic (2020–2022), the number of reported cases of HFMD and varicella decreased to 571 and 389, respectively, with average reporting rates of 0.03% and 0.02%, respectively, which were significantly different from those in the pre-pandemic period (P < 0.001). In the post-pandemic period (2023), the reporting rate of HFMD was 0.07%, showing a marked increase compared with that in 2022 (P < 0.001). However, the difference in the reporting rate of varicella in 2023 did not differ significantly from that in 2022 (P =0.204). These results suggest that non-pharmaceutical interventions implemented during the COVID-19 pandemic might be helpful in preventing the spread of HFMD and varicella.
{"title":"Impact of the COVID-19 pandemic on the epidemiology of hand-foot-and-mouth disease and varicella in a general hospital in Guangzhou, China","authors":"Hui-Hui Wu, Hang Li, Juan-Hua Liu, Lu-Li Song, D. Luo, Yu-Kun Zhao","doi":"10.1097/jd9.0000000000000383","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000383","url":null,"abstract":"We retrospectively reviewed the medical records of patients with hand-foot-and-mouth disease (HFMD) and varicella treated in a general hospital in Guangzhou, China between 2017 and 2023 to evaluate the effect of the coronavirus disease 2019 (COVID-19) on the epidemiology of HFMD and varicella in Guangzhou. The epidemiological characteristics of HFMD and varicella before (2017–2019), during (2020–2022), and after (2023) the pandemic were compared. In total, 1731 cases of HFMD and 1043 cases of varicella were reported before the COVID-19 pandemic (2017–2019), with average reporting rates of 0.08% and 0.05%, respectively. During the COVID-19 pandemic (2020–2022), the number of reported cases of HFMD and varicella decreased to 571 and 389, respectively, with average reporting rates of 0.03% and 0.02%, respectively, which were significantly different from those in the pre-pandemic period (P < 0.001). In the post-pandemic period (2023), the reporting rate of HFMD was 0.07%, showing a marked increase compared with that in 2022 (P < 0.001). However, the difference in the reporting rate of varicella in 2023 did not differ significantly from that in 2022 (P =0.204). These results suggest that non-pharmaceutical interventions implemented during the COVID-19 pandemic might be helpful in preventing the spread of HFMD and varicella.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.1097/jd9.0000000000000384
F. Gaudiello, S. Spennato, F. Cillo, Maria Teresa Cantelli, Maria Vastarella, M. Scalvenzi
Eruptive pseudoangiomatosis (EP) is a rare type of cutaneous exanthema characterized by red angioma-like papules. An association of EP with viral infection has been reported. We herein describe four pediatric patients who showed a new variant of EP-associated rash with atypical clinical features and positivity for parvovirus B19 infection. Pediatric patients showed a new variant of EP-associated rash with atypical clinical features and positivity for parvovirus B19 infection by dermoscopy and reflectance confocal microscopy. The papules were localized to the face and characteristic perilesional halo was absent. In all patients, serology revealed evidence of active infection by parvovirus B19. Few cases of a facial pseudoangiomatous rash that is related to parvovirus B19 infection and lacks the typical anemic halo have been reported in the literature. These cases provide new data on the clinical spectrum of EP and its association with parvovirus.
{"title":"Eruptive pseudoangiomatosis and parvovirus: exclusive clinical findings","authors":"F. Gaudiello, S. Spennato, F. Cillo, Maria Teresa Cantelli, Maria Vastarella, M. Scalvenzi","doi":"10.1097/jd9.0000000000000384","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000384","url":null,"abstract":"\u0000 \u0000 Eruptive pseudoangiomatosis (EP) is a rare type of cutaneous exanthema characterized by red angioma-like papules. An association of EP with viral infection has been reported.\u0000 We herein describe four pediatric patients who showed a new variant of EP-associated rash with atypical clinical features and positivity for parvovirus B19 infection.\u0000 \u0000 \u0000 \u0000 Pediatric patients showed a new variant of EP-associated rash with atypical clinical features and positivity for parvovirus B19 infection by dermoscopy and reflectance confocal microscopy. The papules were localized to the face and characteristic perilesional halo was absent.\u0000 In all patients, serology revealed evidence of active infection by parvovirus B19.\u0000 \u0000 \u0000 \u0000 Few cases of a facial pseudoangiomatous rash that is related to parvovirus B19 infection and lacks the typical anemic halo have been reported in the literature.\u0000 \u0000 \u0000 \u0000 These cases provide new data on the clinical spectrum of EP and its association with parvovirus.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disease characterized by the development of inflammatory nodules, abscesses, and pus-discharging tunnels in areas such as the axillary, inguinal, gluteal, and perianal regions. The pathogenesis of HS remains unclear, but it is being increasingly recognized to rely on the dysregulation of inflammatory responses. Central to this process are macrophages, which have emerged as key players in the inflammatory milieu of HS. These cells orchestrate inflammation via polarization and significantly influence the functions of neighboring cells. This review briefly describes macrophage polarization and crosstalk between macrophages and other cells in patients with HS with the aim of providing new therapeutic strategies for the clinical management of HS.
{"title":"Macrophage Polarization and Crosstalk between Macrophages and Other Cells in Hidradenitis Suppurativa","authors":"Qiujing Zhang, Yibo Feng, Xiang Chen, Xiaohui Mo, Qiong Wu, Qiang Ju","doi":"10.1097/jd9.0000000000000382","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000382","url":null,"abstract":"Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disease characterized by the development of inflammatory nodules, abscesses, and pus-discharging tunnels in areas such as the axillary, inguinal, gluteal, and perianal regions. The pathogenesis of HS remains unclear, but it is being increasingly recognized to rely on the dysregulation of inflammatory responses. Central to this process are macrophages, which have emerged as key players in the inflammatory milieu of HS. These cells orchestrate inflammation via polarization and significantly influence the functions of neighboring cells. This review briefly describes macrophage polarization and crosstalk between macrophages and other cells in patients with HS with the aim of providing new therapeutic strategies for the clinical management of HS.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140383997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1097/jd9.0000000000000366
Jing-Jing Chen, Xiao-Kai Fang, Xiu-Mei Liu, Xiao-Chun Liu, Xu Yao
To assess the relationship between the severity of atopic dermatitis (AD) in children of varying weight categories and their serum 25-hydroxyvitamin D [25(OH)D] levels. The study population comprised 899 patients with AD and 854 age- and sex-matched controls. The Mann-Whitney U test and Kruskal-Wallis H tests were used to assess differences between groups, and Spearman correlation analysis was used to test correlation. The 25(OH)D level in the AD group was M (Q 25, Q 75), 24.0 (19.7, 28.4) ng/mL, which was significantly lower than the control group (26.4 [23.6, 29.9] ng/mL; Z = −3.34, P = 0.001). 25(OH)D levels in children with AD were negatively correlated with body mass index (r = −0.30, P < 0.001), Severity scoring of Atopic Dermatitis (SCORAD; r = −0.14, P < 0.001), total immunoglobulin E (r = −0.13, P < 0.001), and eosinophil (r = −0.08, P = 0.017). There were statistically significant differences in 25(OH)D (H = 18.46, P < 0.001), total immunoglobulin E (H = 9.13, P = 0.010), eosinophil (H = 67.17, P < 0.001), and SCORAD (H = 10.49, P = 0.005) among groups with different body mass index classification. The 25(OH)D levels were 22.3 (17.5, 27.1) ng/mL in the overweight AD group and 22.3 (17.6, 25.7) ng/mL in the obese AD group, which were significantly lower than those in the normal-weight AD group (24.7 [20.4, 25.5] ng/mL; P = 0.003, P = 0.004). 25(OH)D levels were negatively correlated with SCORAD in obese AD patients (r = −0.25, P = 0.010). Vitamin D insufficient or deficient is obvious in children AD patients. The 25(OH)D levels in the overweight/obese AD group are significantly lower than those in the normal-weight AD group. Vitamin D level is negatively correlated with SCORAD in obese children with AD.
{"title":"Serum 25-Hydroxyvitamin D Level Might Be a Useful Indicator of Disease Severity in Obese Children With Atopic Dermatitis: A Case-Control Study","authors":"Jing-Jing Chen, Xiao-Kai Fang, Xiu-Mei Liu, Xiao-Chun Liu, Xu Yao","doi":"10.1097/jd9.0000000000000366","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000366","url":null,"abstract":"\u0000 \u0000 To assess the relationship between the severity of atopic dermatitis (AD) in children of varying weight categories and their serum 25-hydroxyvitamin D [25(OH)D] levels.\u0000 \u0000 \u0000 \u0000 The study population comprised 899 patients with AD and 854 age- and sex-matched controls. The Mann-Whitney U test and Kruskal-Wallis H tests were used to assess differences between groups, and Spearman correlation analysis was used to test correlation.\u0000 \u0000 \u0000 \u0000 The 25(OH)D level in the AD group was M (Q\u0000 25, Q\u0000 75), 24.0 (19.7, 28.4) ng/mL, which was significantly lower than the control group (26.4 [23.6, 29.9] ng/mL; Z = −3.34, P = 0.001). 25(OH)D levels in children with AD were negatively correlated with body mass index (r = −0.30, P < 0.001), Severity scoring of Atopic Dermatitis (SCORAD; r = −0.14, P < 0.001), total immunoglobulin E (r = −0.13, P < 0.001), and eosinophil (r = −0.08, P = 0.017). There were statistically significant differences in 25(OH)D (H = 18.46, P < 0.001), total immunoglobulin E (H = 9.13, P = 0.010), eosinophil (H = 67.17, P < 0.001), and SCORAD (H = 10.49, P = 0.005) among groups with different body mass index classification. The 25(OH)D levels were 22.3 (17.5, 27.1) ng/mL in the overweight AD group and 22.3 (17.6, 25.7) ng/mL in the obese AD group, which were significantly lower than those in the normal-weight AD group (24.7 [20.4, 25.5] ng/mL; P = 0.003, P = 0.004). 25(OH)D levels were negatively correlated with SCORAD in obese AD patients (r = −0.25, P = 0.010).\u0000 \u0000 \u0000 \u0000 Vitamin D insufficient or deficient is obvious in children AD patients. The 25(OH)D levels in the overweight/obese AD group are significantly lower than those in the normal-weight AD group. Vitamin D level is negatively correlated with SCORAD in obese children with AD.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140399774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-06DOI: 10.1097/jd9.0000000000000375
{"title":"Eccrine Spiradenoma of the Forehead: A Case Report","authors":"","doi":"10.1097/jd9.0000000000000375","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000375","url":null,"abstract":"","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139860885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-06DOI: 10.1097/jd9.0000000000000371
{"title":"A novel small deletion in the ATP2A2 gene in a patient with sporadic Darier’s disease and concomitant depression: a case report","authors":"","doi":"10.1097/jd9.0000000000000371","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000371","url":null,"abstract":"","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139802079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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