Temperature dependent pH-instability of some alpha-L-arabinofuranosidases.

Archiv fur Geschwulstforschung Pub Date : 1989-01-01
G Butschak, A Küster, B Schulze, A Graffi
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Abstract

In this paper are described alpha-L-arabinofuranosidases, partially purified from some moulds, with very high lability of their activity to weakly alkaline or neutral pH-values. This pH-lability strongly depends on temperature. The form of the inactivation curves suggests involvement of charge changes in this irreversible process. These enzymes may be useful for optimization of the tumor therapy concept described by Graffi (5).

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一些α - l -阿拉伯糖醛酸苷酶的温度依赖ph不稳定性。
本文描述了部分从某些霉菌中纯化的α - l -阿拉伯糖醛酸苷酶,它们的活性对弱碱性或中性ph值具有很高的稳定性。这种ph稳定性很大程度上取决于温度。失活曲线的形式表明电荷变化参与了这一不可逆过程。这些酶可能有助于优化Graffi(5)描述的肿瘤治疗概念。
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