Mitigating Effect of Cow Urine against Chlorpyrifos Induced Oxidative Stress

Abstract

The present study was planned to evaluate the mitigating effect of cow urine against the detrimental effects induced by Chlorpyrifos (CPF), an organophosphate pesticide, in different tissues of rat. The LD50 was determined and 1/4th of LD50 i.e., 38mg/ kg b.wt was selected for treatment. Sexually mature rats weighing 120±10 g was orally administered with selected dose and cow urine. After 24, 48 and 72 hours biochemical analysis was done using different biomarkers in different tissues. In light of available data, it was deduced that CPF has propensity to cause marked perturbations in the antioxidant enzymes. Further, cow urine mitigated the oxidative stress induced by CPF in different tissues. Thus, this study emphasizes the importance of use of cow urine as a natural source of antioxidants which could be beneficial in the therapeutic world for the treatment of various disorders implicating oxidative stress.