Dinh Thuy Van, P. T. Chính, Pham Thi Tham, Mai Thanh Nga, Thongsaving Ounkuea
{"title":"Chemical components as a potential resource for synthesis of organic compounds and anti-inflammatory activity of essential bark oil of Illicium verum","authors":"Dinh Thuy Van, P. T. Chính, Pham Thi Tham, Mai Thanh Nga, Thongsaving Ounkuea","doi":"10.25303/281rjce68072","DOIUrl":null,"url":null,"abstract":"In this work, the essential bark oil (EBO) of Illicium verum cultivated at Cao Bang in Vietnam obtained by hydro-distillation was investigated for its chemical composition by gas chromatography-mass spectrometry (GC-MS). Trans-anethole (78.6%), estragole (13.7%), linalool (2.1%) and eucalyptol (2.0%) were determined to be the main components among 14 identified compounds, which accounted for 96.4% of the total EBO. Anti-inflammatory activity of EBO was evaluated by inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. EBO exhibited an interesting inhibitory effect on NO production in LPS-stimulated RAW246.7 cells with an inhibitory value at 93.87 μg/mL. From the starting material, trans-anethole isolated from EBO, there are two new amine-derivatives that were synthesized. The structure elucidation of these analogues of trans-anethole was carried out by 1D (1H NMR and 13C NMR) and IR spectral analysis.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research Journal of Chemistry and Environment","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25303/281rjce68072","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Earth and Planetary Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
In this work, the essential bark oil (EBO) of Illicium verum cultivated at Cao Bang in Vietnam obtained by hydro-distillation was investigated for its chemical composition by gas chromatography-mass spectrometry (GC-MS). Trans-anethole (78.6%), estragole (13.7%), linalool (2.1%) and eucalyptol (2.0%) were determined to be the main components among 14 identified compounds, which accounted for 96.4% of the total EBO. Anti-inflammatory activity of EBO was evaluated by inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. EBO exhibited an interesting inhibitory effect on NO production in LPS-stimulated RAW246.7 cells with an inhibitory value at 93.87 μg/mL. From the starting material, trans-anethole isolated from EBO, there are two new amine-derivatives that were synthesized. The structure elucidation of these analogues of trans-anethole was carried out by 1D (1H NMR and 13C NMR) and IR spectral analysis.
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