Multiple serum enzyme level changes in chronic alcoholic with special reference to gamma-glutamyl transpeptidase and lipid peroxidase

Abstract

Chronic alcohol intake can lead to functional disturbances and irreversible lesions in organs such as the liver, brain, pancreas, gastrointestinal tract, heart, and endocrine gland. Determining the serum activities of various enzymes such as aminotransferases, glutamate dehydrogenase (GDH), and gamma-glutamyltransferase (GGT) has widely been used as a method of screening for hepatic involvement in chronic alcoholism.This study was conducted to analyze multiple serum enzyme level changes in a chronic alcoholic with special reference to GGT and lipid peroxidase34 subjects were selected for the study. They are all male individuals with a positive history of chronic alcohol abuse. 10 healthy male volunteers who matched in age and socioeconomic status served as the controls.: The activity of serum enzyme levels in test and control groups has been statistically analyzed. There was a highly significant difference (p<0.001) in the mean values of the Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), GGT of these two groups, whereas Serum lipid peroxidase (SLP) was less significant (p<0.01). The concentration of GGT was significantly low (p<0.001) in controls compared to that in the alcoholics.GGT can be taken as a marker of chronic alcoholism, provided serum bilirubin, SAP is within the reasonably average level