Clinical profile, management and outcomes of pseudoexfoliation syndrome with glaucoma in a tertiary eye care hospital

Abstract

To study the clinical profile, management and outcomes of pseudoexfoliation (PXF) syndrome with glaucoma in a tertiary eye care hospital.This is a prospective hospital based interventional study over a period of two years from January 2020 to December 2022. 300 eyes of 150 cases aged between forty to ninety years, visiting OPD and diagnosed with PXF syndrome with glaucoma were enrolled in the current study. Cases with other causes of glaucoma, ocular trauma or surgery, cases who were lost on follow-up were excluded. In our study, 67% eyes with PXF syndrome were non-glaucomatous and 33% (300 eyes) were glaucomatous which was taken as the study population. PXF syndrome cases having glaucoma showed 43 % of PXF glaucoma, 27% primary open angle glaucoma, 18 % primary angle closure glaucoma and 12 % normal tension glaucoma respectively. Bilateral glaucoma was seen in 83% .Mean Intra ocular Pressure (IOP) of the cases was found to be 18.28 ± 3.48 mmHg. Surgical intervention was done in 20% with surgical complications reported among 16.7 % eyes. Mean IOP after 1 month and 12 month of surgery was 16.8 mmHg and 14.6 mmHg respectively.Greater prevalence rate was found with age greater than 60 yrs, mean being 64 yrs and there was no gender predilection.We observed a greater incidence of PXF syndrome with glaucoma in our region and a positive statistical correlation with increasing age, poor mydriasis and progressive glaucomatous optic neuropathy unresponsive to medical management.Rate of surgical complications was very high.Hence, Ophthalmologists must emphasize on screening and meticulous preoperative examination of PXF to avoid intraoperative complications in these cases.