Risk Factors of Meibomian Gland Loss in Dry Eye Disease

Ye-Tao Jin, Jong Hyuck Lee, Sun Woong Kim
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Abstract

Purpose: To determine the risk factors of meibomian gland loss in dry eye disease.Methods: The medical charts of 229 dry eye disease patients who had a meibography were retrospectively reviewed. They were divided into 4 groups according to the degree of meibomian gland loss. Telangiectasia and irregularity of eyelid margin, Ocular Surface Disease Index (OSDI), non invasive breakup time (NIBUT), lipid layer thickness (LLT) and tear meniscus height (TMH) were compared. Age, gender, history of eyeline tattoo, history of hypertension, diabetes, dyslipidemia, chemotherapy, radiation therapy, hormone therapy and autoimmune diseases were also investigated to analyze the correlation with the severe meibomian gland loss. Severe meibomian gland loss was defined as loss of more than 75% of the conjunctival area, and risk factors were evaluated using logistic regression analysis.Results: Comparing the four groups divided according to the degree of meibomian gland loss, the group with severe meibomian gland loss was older (p = 0.001), had lower LLT (p < 0.001), had a higher frequency of eyeline tattoos. The ratio of hyperlipidemia (p < 0.001) and chemotherapy (p < 0.001) was also high in the group with severe meibomian gland loss. As a result of multiple logistic regression analysis, age, eyeline tattoo, hyperlipidemia, and chemotherapy were variables that had a significant effect on sever meibomian gland loss. (p < 0.05)Conclusions: Age and history of eyeline tattoo, hyperlipidemia, and chemotherapy are significant variables that cause severe meibomian gland loss in dry eye disease patients. J Korean Ophthalmol Soc 2023;64(12):1152-1157
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干眼症患者睑板腺功能丧失的风险因素
目的:确定干眼症患者睑板腺脱落的风险因素:回顾性审查了 229 名接受过meibography检查的干眼症患者的病历。根据睑板腺脱落的程度将他们分为 4 组。比较了眼睑边缘的远端扩张和不规则、眼表疾病指数(OSDI)、非侵入性破裂时间(NIBUT)、脂质层厚度(LLT)和泪液半月板高度(TMH)。此外,还调查了年龄、性别、眼线纹身史、高血压史、糖尿病史、血脂异常史、化疗史、放疗史、激素治疗史和自身免疫性疾病史,以分析这些因素与严重睑板腺脱落的相关性。严重睑板腺脱落的定义是结膜脱落面积超过75%,风险因素采用逻辑回归分析进行评估:结果:根据睑板腺脱落程度划分的四组进行比较,严重睑板腺脱落组年龄较大(p = 0.001),LLT较低(p < 0.001),眼线纹身频率较高。高脂血症(p < 0.001)和化疗(p < 0.001)在严重睑板腺脱落组中的比例也较高。多重逻辑回归分析结果显示,年龄、眼线纹身、高脂血症和化疗是对严重睑板腺脱落有显著影响的变量。(P<0.05)结论:年龄、眼线纹身史、高脂血症和化疗是导致干眼症患者睑板腺严重脱落的重要变量。J Korean Ophthalmol Soc 2023;64(12):1152-1157
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