Multiple-lesion, non-familial basal cell carcinoma-An interesting oddity

S. Kadam, K. Pardeshi, Hoogar Mallinath Basalingappa, Satish Bhasale, Vaishali Bhonsle, Nakul Y Sampat, A. Valand
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Abstract

Basal cell carcinoma (BCC) is the most common primary carcinoma of skin, which accounts for three-fourth of all primary skin tumours. Basal carcinoma occurs commonly as a single lesion, though occasionally it can occur as Multiple lesions, which may occur in close association with heredofamilial conditions such as nevoid basal cell carcinoma syndrome (Gorlin’s syndrome), Bazex syndrome, Rombo syndrome, and unilateral basal cell nevus syndrome. The case of multiple basal cell carcinomas being presented here is unique in its occurrence inasmuch as it is not associated with heredofamilial conditions, and despite not being associated with heredofamilial conditions there is occurrence of multiple basal carcinomas in a patient in a tertiary care hospital in a dominantly tribal region. The patient has no family history of genodermatosis that could increase the incidence of multiple basal cell carcinomas such as xeroderma pigmentosum, and no history of other predisposing conditions including actinic keratosis, Bowen’s Disease, leukoplakia, Erythroplasia of Queyrat, keratoacanthoma, radiation dermatitis and exposure to arsenicals, psoralen and other photosensitizing medications. However, the patient had history of having raised macules over the face which were diagnosed as seborrheic keratosis.
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多病灶、非家族性基底细胞癌--有趣的怪事
基底细胞癌(BCC)是最常见的原发性皮肤癌,占所有原发性皮肤肿瘤的四分之三。基底细胞癌通常为单发病变,但偶尔也会出现多发病变,可能与家族性疾病密切相关,如无痣基底细胞癌综合征(戈林综合征)、巴泽克斯综合征、罗姆博综合征和单侧基底细胞痣综合征。这里介绍的多发性基底细胞癌病例是一个独特的病例,因为它的发生与家族遗传病无关,尽管与家族遗传病无关,但在一个以部落为主的地区的三甲医院中,一名患者却发生了多发性基底细胞癌。该患者没有可能增加多发性基底细胞癌发病率的遗传性皮肤病(如色素沉着病)家族史,也没有其他易感疾病史,包括光化性角化病、鲍温氏病、白斑病、奎拉特红斑、角化棘皮瘤、放射性皮炎以及砷剂、补骨脂素和其他光敏药物接触史。然而,患者面部曾有凸起的斑丘疹,被诊断为脂溢性角化病。
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