Association Between Tear Osmolarity and Dry Eye Signs in Patients with Obstructive Meibomian Gland Dysfunction

Han Sol Choi, Si Hyung Lee
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Abstract

Purpose: To explore the correlations between tear osmolarity, as measured using I-PEN® (I-MED Pharma, Inc., Dollard-des-Ormeaux, QC, Canada), and various dry eye indicators, including the Schirmer test, tear break-up time (TBUT), Oxford scale, and Ocular Surface Disease Index (OSDI), in patients with obstructive meibomian gland dysfunction (MGD).Methods: The medical records of 44 cases of obstructive MGD were reviewed. Tear osmolarity was obtained using I-PEN® (I-MED Pharma, Inc.). The TBUT, Schirmer test, Oxford scale, OSDI, and MGD grade were used to assess the cases, and their correlations with tear osmolarity were analyzed.Results: Spearman and Pearson correlation analyses showed a significant correlation between tear osmolarity and MGD grade (p < 0.001) and OSDI (p = 0.005). However, the results of the TBUT, Schirmer test, and Oxford scale were not significantly related to tear osmolarity. The patients were divided according to MGD severity into those with MGD grades ≤ 2 and those with MGD grades ≥ 3. Tear osmolarity (p < 0.001) and OSDI (p = 0.014) showed significant differences between the two groups.Conclusions: In patients with obstructive MGD, tear osmolarity, assessed using I-PEN® (I-MED Pharma, Inc.), is significantly correlated with MGD grade and OSDI.
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泪液渗透压与睑板腺功能障碍患者干眼症状之间的关系
目的:探讨阻塞性睑板腺功能障碍(MGD)患者使用 I-PEN® (I-MED Pharma, Inc., Dollard-des-Ormeaux, QC, Canada)测量的泪液渗透压与各种干眼指标(包括 Schirmer 试验、泪液破裂时间(TBUT)、牛津量表和眼表疾病指数(OSDI))之间的相关性:方法:回顾 44 例阻塞性睑板腺功能障碍患者的病历。使用 I-PEN® (I-MED Pharma, Inc.) 采集泪液渗透压。采用 TBUT、Schirmer 试验、牛津量表、OSDI 和 MGD 分级对病例进行评估,并分析其与泪液渗透压的相关性:结果:Spearman 和 Pearson 相关性分析表明,泪液渗透压与 MGD 等级(p < 0.001)和 OSDI(p = 0.005)之间存在显著相关性。然而,TBUT、Schirmer 试验和牛津量表的结果与泪渗透压无明显关系。根据 MGD 的严重程度,将患者分为 MGD 等级≤2 级和 MGD 等级≥3 级。两组患者的泪液渗透压(p < 0.001)和OSDI(p = 0.014)有显著差异:在阻塞性 MGD 患者中,使用 I-PEN® (I-MED Pharma, Inc.) 评估的泪液渗透压与 MGD 分级和 OSDI 显著相关。
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