Histopathological prognostic factors in post NACT ovarian cancers: A retrospective study

Abstract

Epithelial ovarian carcinoma is the most common type of all the ovarian cancers. The patients with advanced stage are initially treated with neo-adjuvant chemotherapy followed by interval debulking surgery. The high mortality rate is mainly due to advanced stage disease at initial presentation. This a retrospective study carried out in department of pathology at Bhagwan Mahaveer cancer hospital, Jaipur. The retrospective cases data was collected and analyzed from patient records on basis of inclusion and exclusion criteria.: Patients of advanced ovarian cancer with fibrosis grade 3, necrosis grade 2, presence of psammoma bodies, presence of collagen deposition, low Ki67 index, positive ER status were associated with longer DFS (p value= 0.014,0.029,0.033,0.028,0.001 and 0.001 respectively) and OS (P value 0.025,0.005,0.002,0.015,0.001 and 0.001 respectively).We propose that the prognostic histopathological parameters analysed in our study in post NACT patients of ovarian carcinoma should be reported in final histopathological report, as these factors can provide an extra tool for clinicians to optimize patient management and care.