Mucinous cystic neoplasm of the liver is a rare cystic neoplasm accounting for approx. 5% of cystic liver in the liver parenchyma. We describe the histomorphology and immunophenotyping features of MCN-L in a 52-year-old woman who came to the surgical department with complaints of pain abdomen for 1.5 months. The ultrasonography showed a septated cyst located centrally in the liver. The CT abdomen showed a large hypodense multiloculated cystic lesion in the liver with thin enhancing septae and multiple small cysts involving the entire left lobe with extension into the right lobe and having a large infra-hepatic exophytic component. A provisional diagnosis of a Hydatid cyst was made. Drainage of the cyst with laparoscopic deroofing was done. Histopathology examination showed a cyst lined by cuboidal to columnar epithelium with mucinous cytoplasm and basally oriented nuclei. Subepithelium shows ovarian-like stroma. MCN-L has a lower frequency as compared to the counterpart of MCN in the pancreas, and further molecular studies are necessary to clarify the biology of MCN-L. The relevance of this rare entity's clinical and radiological suspicion, histological recognition and immunohistochemistry is emphasised.
{"title":"Mucinous cystic neoplasm of the liver: A rare case report","authors":"Tanya Prasad, Dipti Anu, Madhu Kumari, Kislay Kant","doi":"10.18231/j.ijpo.2024.038","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.038","url":null,"abstract":"Mucinous cystic neoplasm of the liver is a rare cystic neoplasm accounting for approx. 5% of cystic liver in the liver parenchyma. We describe the histomorphology and immunophenotyping features of MCN-L in a 52-year-old woman who came to the surgical department with complaints of pain abdomen for 1.5 months. The ultrasonography showed a septated cyst located centrally in the liver. The CT abdomen showed a large hypodense multiloculated cystic lesion in the liver with thin enhancing septae and multiple small cysts involving the entire left lobe with extension into the right lobe and having a large infra-hepatic exophytic component. A provisional diagnosis of a Hydatid cyst was made. Drainage of the cyst with laparoscopic deroofing was done. Histopathology examination showed a cyst lined by cuboidal to columnar epithelium with mucinous cytoplasm and basally oriented nuclei. Subepithelium shows ovarian-like stroma. MCN-L has a lower frequency as compared to the counterpart of MCN in the pancreas, and further molecular studies are necessary to clarify the biology of MCN-L. The relevance of this rare entity's clinical and radiological suspicion, histological recognition and immunohistochemistry is emphasised.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"49 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141644684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.030
Bazila Mansoor, Sheeba Parvez, Rimsha Ahmed, A. Khajuria
The aim of the study is to ascertain whether there happens to be any relation between the histological grading (according to broders system) of oral squamous cell carcinoma cases and their regional metastasis, depth of invasion and perineural invasion. Squamous cell carcinoma is known to be the most common malignancy of the oral cavity. Staging and grading of OSCC are established are the main requirements for management, because they influence risk stratification and are one of the first step towards personalized treatment. Histological grading was introduced for the first time by Broder’s for squamous cell carcinomas of lip.: This is a retrospective study of 53 patients who were diagnosed as oral squamous cell carcinomas from April 2021 to January 2023. The specimen of the cases were sent to our Department of Pathology, Acharya Shri Chandra college of medical sciences and hospital, Jammu for histopathological examination after resection.: Broder’s grading does co relate to the metastasis, depth of invasion and perineural invasion. There should be more studies at a larger level to ascertain the potential of Breslow grading.
{"title":"Oral squamous cell carcinoma: Histological grading and co relationship with cervical metastasis, depth of invasion and perineural invasion","authors":"Bazila Mansoor, Sheeba Parvez, Rimsha Ahmed, A. Khajuria","doi":"10.18231/j.ijpo.2024.030","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.030","url":null,"abstract":"The aim of the study is to ascertain whether there happens to be any relation between the histological grading (according to broders system) of oral squamous cell carcinoma cases and their regional metastasis, depth of invasion and perineural invasion. Squamous cell carcinoma is known to be the most common malignancy of the oral cavity. Staging and grading of OSCC are established are the main requirements for management, because they influence risk stratification and are one of the first step towards personalized treatment. Histological grading was introduced for the first time by Broder’s for squamous cell carcinomas of lip.: This is a retrospective study of 53 patients who were diagnosed as oral squamous cell carcinomas from April 2021 to January 2023. The specimen of the cases were sent to our Department of Pathology, Acharya Shri Chandra college of medical sciences and hospital, Jammu for histopathological examination after resection.: Broder’s grading does co relate to the metastasis, depth of invasion and perineural invasion. There should be more studies at a larger level to ascertain the potential of Breslow grading.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.025
Banushree C S
{"title":"The impact of knowledge, attitude, and perception of blood donation among college students","authors":"Banushree C S","doi":"10.18231/j.ijpo.2024.025","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.025","url":null,"abstract":"","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"34 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Composite hemangioendothelioma (CHE) is an intermediate grade neoplastic tumor of vascular origin. It consists of a varied mixture of benign, intermediate and malignantvascular components. Only few cases of CHE occurring in different soft tissue areas of the body and rarely in internal organs have been reported in literature till now. We report a case of CHE presenting as lump in the breast in a 42 year old female. A review of literature is also presented to create awareness of this entity which can be misleading in breast where angiosarcoma is also known to occur.
复合型血管内皮瘤（CHE）是一种血管源性中级肿瘤。它由各种良性、中度和恶性血管成分混合而成。迄今为止，只有少数文献报道了发生在身体不同软组织部位的 CHE 病例，很少有发生在内脏器官的病例。我们报告了一例以乳房肿块为表现的 CHE 病例，患者为 42 岁女性。我们还对文献进行了回顾，以提高人们对乳腺血管肉瘤的认识。
{"title":"Composite hemangioendothelioma of breast: A case report with review of literature","authors":"Kannar Vidyavathi, Akshatha Bissegowda, Dharmapalan Anantharaman, Haruvanahalli Basappa Kavyashri","doi":"10.18231/j.ijpo.2024.040","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.040","url":null,"abstract":"Composite hemangioendothelioma (CHE) is an intermediate grade neoplastic tumor of vascular origin. It consists of a varied mixture of benign, intermediate and malignantvascular components. Only few cases of CHE occurring in different soft tissue areas of the body and rarely in internal organs have been reported in literature till now. We report a case of CHE presenting as lump in the breast in a 42 year old female. A review of literature is also presented to create awareness of this entity which can be misleading in breast where angiosarcoma is also known to occur.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"38 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: CSF examination is the gold standard for diagnosing leptomeningeal metastases. Malignant cells may access the subarachnoid space by hematogenous dissemination, spreading directly from parenchymal brain lesions, or spreading along the spinal cord or cranial nerves. Cytological detection of malignant cells in CSF is still a crucial decision point for systemic and intrathecal chemotherapy, and it has prognostic significance even with improvements in biochemical analysis and CNS imaging. Over the course of two years, a total of 397 patients—regardless of gender and age—were investigated. There were sixty-four cases with involvement of the central nervous system documented, comprising 42 hematologic malignancies and 22 solid tumors. Cell centrifugation (Cytospin) method were used to prepare smears and cell blocks where prepared, as feasible and indicated. : A cytological analysis of the cerebrospinal fluid showed that metastatic tumors were much more prevalent than primary central nervous system tumours. Lung tumors were the most frequent primary site in our analysis, with breast, gastrointestinal, and female genital tract malignancies following closely behind. CNS involvement has been reported in patients with Lymphoma (DLBCL) and Leukemia (most commonly ALL, but also AML and JMML) among hematological malignancies. Two cases of Retinoblastoma and one each of Medulloblastoma and an Atypical teratoid/rhabdoid tumor were observed in the pediatric age group.: Cerebrospinal fluid cytology is a simple and useful method, used as a primary diagnostic method in the evaluation of leptomeningeal metastases. This helps in the early detection of secondary CNS lesions and allows for timely intervention, prognosis, and prediction of overall survival.
{"title":"Cerebrospinal fluid cytology: A theragnostic and prognostic tool- Experience from a tertiary cancer care centre in central India","authors":"Shraddha Mahindra, Meena Pangarkar, Kishor Deshpande, Radhika Pagey, Shweta Deulkar","doi":"10.18231/j.ijpo.2024.033","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.033","url":null,"abstract":": CSF examination is the gold standard for diagnosing leptomeningeal metastases. Malignant cells may access the subarachnoid space by hematogenous dissemination, spreading directly from parenchymal brain lesions, or spreading along the spinal cord or cranial nerves. Cytological detection of malignant cells in CSF is still a crucial decision point for systemic and intrathecal chemotherapy, and it has prognostic significance even with improvements in biochemical analysis and CNS imaging. Over the course of two years, a total of 397 patients—regardless of gender and age—were investigated. There were sixty-four cases with involvement of the central nervous system documented, comprising 42 hematologic malignancies and 22 solid tumors. Cell centrifugation (Cytospin) method were used to prepare smears and cell blocks where prepared, as feasible and indicated. : A cytological analysis of the cerebrospinal fluid showed that metastatic tumors were much more prevalent than primary central nervous system tumours. Lung tumors were the most frequent primary site in our analysis, with breast, gastrointestinal, and female genital tract malignancies following closely behind. CNS involvement has been reported in patients with Lymphoma (DLBCL) and Leukemia (most commonly ALL, but also AML and JMML) among hematological malignancies. Two cases of Retinoblastoma and one each of Medulloblastoma and an Atypical teratoid/rhabdoid tumor were observed in the pediatric age group.: Cerebrospinal fluid cytology is a simple and useful method, used as a primary diagnostic method in the evaluation of leptomeningeal metastases. This helps in the early detection of secondary CNS lesions and allows for timely intervention, prognosis, and prediction of overall survival.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"14 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.039
Srinivas Bheemanathi Hanuman, Soundarya Ravi, B. Pottakkat
Incidental intrahepatic cholangiocarcinoma (i-ICCA) is an uncommonly encountered malignancy in an explant liver. The presence of i-ICCA in an explant liver indicates poor prognosis and high chances of recurrence. Therefore, histopathological diagnosis of i-ICCA in an explant liver specimen is crucial for the patient. In this case report, we present a case of i-ICCA diagnosed in an explant liver showing features of alcoholic cirrhosis with a brief discussion on its salient features and relevant differential diagnoses.
{"title":"Incidental detection of intrahepatic cholangiocarcinoma in an explant liver: An unforeseen encounter","authors":"Srinivas Bheemanathi Hanuman, Soundarya Ravi, B. Pottakkat","doi":"10.18231/j.ijpo.2024.039","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.039","url":null,"abstract":"Incidental intrahepatic cholangiocarcinoma (i-ICCA) is an uncommonly encountered malignancy in an explant liver. The presence of i-ICCA in an explant liver indicates poor prognosis and high chances of recurrence. Therefore, histopathological diagnosis of i-ICCA in an explant liver specimen is crucial for the patient. In this case report, we present a case of i-ICCA diagnosed in an explant liver showing features of alcoholic cirrhosis with a brief discussion on its salient features and relevant differential diagnoses.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.048
D. Gochhait, Paruvathavarthini Thambiraj, Norton S. Stephen, N. Siddaraju
Generally metastasis implies malignancy, but there are some benign tumours which can also metastasize to lymph nodes, bone, and kidney. The benign tumours which can metastasize includes pleomorphic adenoma, leiomyoma, giant cell tumour of bone and meningioma. A 27 years old female presented to the cytology clinic with the submandibular swelling for past 3 months. Patient is a known case of pleomorphic adenoma post-surgery in the same region 6 years back. On examination two nodular swelling each measuring 1 x 1 which is firm mobile near scar site and left level III lymph node region. A non-guided fine needle aspiration cytology was performed from both the swelling. The Papanicolaou- and May-Grünwald Giemsa-stained smears from both sites showed features of pleomorphic adenoma. The interesting aspect of this article is cytological diagnosis of benign pleomorphic adenoma metastasizing to lymph nodes which is a rare entity.
一般来说，转移意味着恶性肿瘤，但有些良性肿瘤也会转移到淋巴结、骨骼和肾脏。可以转移的良性肿瘤包括多形性腺瘤、子宫肌瘤、骨巨细胞瘤和脑膜瘤。一名 27 岁的女性因颌下腺肿胀 3 个月前来细胞学门诊就诊。患者曾在 6 年前的同一部位做过多形性腺瘤手术。经检查，疤痕部位和左侧 III 级淋巴结区域附近有两个结节状肿物，大小各为 1 x 1，质地坚硬，可移动。对这两个肿物进行了无引导细针穿刺细胞学检查。两个部位的巴氏涂片和梅-格林瓦尔德吉氏涂片均显示为多形性腺瘤。这篇文章的有趣之处在于对转移到淋巴结的良性多形性腺瘤进行了细胞学诊断，而这种情况并不多见。
{"title":"Benign metastasizing tumor or benign epithelial inclusion in the node: A diagnostic dilemma","authors":"D. Gochhait, Paruvathavarthini Thambiraj, Norton S. Stephen, N. Siddaraju","doi":"10.18231/j.ijpo.2024.048","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.048","url":null,"abstract":"Generally metastasis implies malignancy, but there are some benign tumours which can also metastasize to lymph nodes, bone, and kidney. The benign tumours which can metastasize includes pleomorphic adenoma, leiomyoma, giant cell tumour of bone and meningioma. A 27 years old female presented to the cytology clinic with the submandibular swelling for past 3 months. Patient is a known case of pleomorphic adenoma post-surgery in the same region 6 years back. On examination two nodular swelling each measuring 1 x 1 which is firm mobile near scar site and left level III lymph node region. A non-guided fine needle aspiration cytology was performed from both the swelling. The Papanicolaou- and May-Grünwald Giemsa-stained smears from both sites showed features of pleomorphic adenoma. The interesting aspect of this article is cytological diagnosis of benign pleomorphic adenoma metastasizing to lymph nodes which is a rare entity.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"76 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.036
Divya Gordhanbhai Patel, Pragati Atulbhai Shah, Raj D Shah, Minesh B Gandhi, Cherry K Shah
Inflammatory fibroid polyps (IFPs) are uncommon benign solitary mesenchymal neoplasms which may develop anywhere in the gastrointestinal tract. These submucosal lesions can occur in individuals of any age but are more frequently observed in the 6th or 7th decade of life. Although rarely associated with adenoma or adenocarcinoma, IFPs are typically managed through local excision. The clinical presentation varies depending on the anatomical location of the polyp. Gross examination typically reveals localized submucosal sessile polypoidal masses. Microscopically, IFPs are characterized by inflammatory cell infiltrate, spindle shaped cells and prominent capillaries. These benign lesions have unknown pathogenesis. Below mentioned are two case report of inflammatory fibroid polyps which lead to intussusception.
{"title":"Inflammatory fibroid polyps of small and large intestine: Report of two cases","authors":"Divya Gordhanbhai Patel, Pragati Atulbhai Shah, Raj D Shah, Minesh B Gandhi, Cherry K Shah","doi":"10.18231/j.ijpo.2024.036","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.036","url":null,"abstract":"Inflammatory fibroid polyps (IFPs) are uncommon benign solitary mesenchymal neoplasms which may develop anywhere in the gastrointestinal tract. These submucosal lesions can occur in individuals of any age but are more frequently observed in the 6th or 7th decade of life. Although rarely associated with adenoma or adenocarcinoma, IFPs are typically managed through local excision. The clinical presentation varies depending on the anatomical location of the polyp. Gross examination typically reveals localized submucosal sessile polypoidal masses. Microscopically, IFPs are characterized by inflammatory cell infiltrate, spindle shaped cells and prominent capillaries. These benign lesions have unknown pathogenesis. Below mentioned are two case report of inflammatory fibroid polyps which lead to intussusception.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"94 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastrointestinal (GI) carcinomas is a term for group of cancers that affect the digestive system. This includes oesophageal, gallbladder, liver, pancreatic, stomach, and bowel cancers. Young-onset colorectal cancer (CRC) is defined as CRC that manifests in people under the age of 50 years. The incidence of CRC in young people has increased by 2% to 8% annually. Small bowel cancer is one of the rare types of cancer as its incidence accounts for less than 1% of all other types of cancer in the United States. Most of these tumors occur in older adults; > 90% of cases occur in people older than 40 years. Here, we are presenting four cases of young onset GI carcinomas. GI carcinomas is now being reported in younger population, therefore it is important to be aware of symptoms and risk factors in them. Here, we are presenting four cases of young onset GI carcinomas in female patients aged 22 and 24 and two male patients aged 21 and 32.
{"title":"Gastrointestinal carcinomas in young adults- Case series","authors":"Ankita Yadav, Noorin Zaidi, Sumaiya Irfan, Nirupama Lal, Iqra Sheikh","doi":"10.18231/j.ijpo.2024.034","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.034","url":null,"abstract":"Gastrointestinal (GI) carcinomas is a term for group of cancers that affect the digestive system. This includes oesophageal, gallbladder, liver, pancreatic, stomach, and bowel cancers. Young-onset colorectal cancer (CRC) is defined as CRC that manifests in people under the age of 50 years. The incidence of CRC in young people has increased by 2% to 8% annually. Small bowel cancer is one of the rare types of cancer as its incidence accounts for less than 1% of all other types of cancer in the United States. Most of these tumors occur in older adults; > 90% of cases occur in people older than 40 years. Here, we are presenting four cases of young onset GI carcinomas. GI carcinomas is now being reported in younger population, therefore it is important to be aware of symptoms and risk factors in them. Here, we are presenting four cases of young onset GI carcinomas in female patients aged 22 and 24 and two male patients aged 21 and 32.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"11 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microsatellite instability (MSI) and mismatch repair (MMR) deficiency are important biomarkers in colorectal cancer (CRC) that have clinical implications for patient management and treatment. MMR deficiency can lead to MSI, which is characterized by alterations in the length of microsatellite DNA sequences. Clinical applications of MMR deficiency in colorectal adenocarcinoma are as a prognostic marker as well as Predictive marker for adjuvant chemotherapy and immunotherapy. To assess the MMR status of colorectal adenocarcinomas.: This was a retrospective study of 127 colorectal adenocarcinomas cases. All the samples were either biopsies or surgically resected tumor tissues from patients of Carcinoma Colon and rectum. Immunohistochemistry was performed on Roche Ventana Benchmark XT autostainer.: MLH-1, PMS2, MSH2 and MSH6 expression was retained in the tumor cells in 106 cases and it was lost in 21 cases. Among various clinicopathological variables, tumor site and AJCC pStage were found to be significantly associated with dMMR tumors. Patients of colorectal adenocarcinomas were benefited by MMR testing as it influenced the adjuvant treatment in all Stage IIA cases as well as all metastatic cases. Incorporating MMR testing into routine clinical practice can help optimize patient management and treatment strategies in CRC.
{"title":"MMR status of colorectal carcinomas at a tertiary cancer care centre in Central India","authors":"Meena Pangarkar, Satabdi Das, Radhika Pagey, Shweta Deulkar, Shraddha Mahindra, Yogita Devi, Anand Pathak","doi":"10.18231/j.ijpo.2024.031","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.031","url":null,"abstract":"Microsatellite instability (MSI) and mismatch repair (MMR) deficiency are important biomarkers in colorectal cancer (CRC) that have clinical implications for patient management and treatment. MMR deficiency can lead to MSI, which is characterized by alterations in the length of microsatellite DNA sequences. Clinical applications of MMR deficiency in colorectal adenocarcinoma are as a prognostic marker as well as Predictive marker for adjuvant chemotherapy and immunotherapy. To assess the MMR status of colorectal adenocarcinomas.: This was a retrospective study of 127 colorectal adenocarcinomas cases. All the samples were either biopsies or surgically resected tumor tissues from patients of Carcinoma Colon and rectum. Immunohistochemistry was performed on Roche Ventana Benchmark XT autostainer.: MLH-1, PMS2, MSH2 and MSH6 expression was retained in the tumor cells in 106 cases and it was lost in 21 cases. Among various clinicopathological variables, tumor site and AJCC pStage were found to be significantly associated with dMMR tumors. Patients of colorectal adenocarcinomas were benefited by MMR testing as it influenced the adjuvant treatment in all Stage IIA cases as well as all metastatic cases. Incorporating MMR testing into routine clinical practice can help optimize patient management and treatment strategies in CRC.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"116 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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