Long-term Longitudinal Analysis of Subfoveal Choroidal Thickness Following Sulodexide Treatment in Diabetic Retinopathy Patients

Chang Min Cha, Jae Wan Lim, C. Kim, Seung Uk Lee, Sang Joon Lee
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Abstract

Purpose: To evaluate the two-year longitudinal changes in subfoveal choroidal thickness (CT) following sulodexide treatment in patients with diabetic retinopathy.Methods: Thirty-eight eyes from patients with diabetic retinopathy, followed for a minimum of two years after sulodexide administration, were included. Subfoveal CT, measured using optical coherence tomography, was analyzed prospectively. Variables including age, sex, duration of diabetes mellitus, HbA1c, blood pressure, sulodexide treatment duration, refractive error, axial length, central macular thickness (CMT), visual acuity, laser photocoagulation, and intravitreal anti-vascular endothelial growth factor injections were evaluated for potential effects on CT. CMT, subfoveal CT, and choroidal vascularity index were compared at baseline and at 6, 12, and 24 months after sulodexide.Results: Of the 38 eyes, 10 belonged to males and 28 to females. The mean data were as follows: age, 67.18 ± 8.87 years; duration of diabetes, 18.11 ± 7.57 years; HbA1c, 8.76 ± 1.60 mmol/L; systolic blood pressure, 134.69 ± 14.68 mmHg; diastolic blood pressure, 73.72 ± 11.90 mmHg; duration of sulodexide, 25.79 ± 3.17 months; refractive error, 0.22 ± 2.19 diopters (D); and axial length, 23.32 ± 0.89 mm. During the observation period, 15 eyes underwent laser photocoagulation and 17 eyes received intravitreal anti-vascular endothelial growth factor injections. The mean subfoveal CT was 216.00 ± 64.23 μm before sulodexide administration and increased to 223.87 ± 62.18 μm, 225.53 ± 62.02 μm, and 225.76 ± 63.62 μm at 6, 12, and 24 months, respectively (p = 0.0377, p = 0.0159, p = 0.0135). The CMT was 318.14 ± 102.28 μm initially and changed to 313.08 ± 77.47 μm, 314.97 ± 88.32 μm, and 320.03 ± 97.36 μm at the aforementioned intervals, with no significant variation (p = 0.904, p = 0.736, p = 0.892).Conclusions: Sulodexide administration led to a significant rise in subfoveal CT over a 2-year follow-up. This change in CT was not mirrored in the CMT.
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糖尿病视网膜病变患者接受舒洛地特治疗后眼底脉络膜厚度的长期纵向分析
目的:评估舒洛地特治疗糖尿病视网膜病变患者两年后眼底脉络膜厚度(CT)的纵向变化:方法:纳入糖尿病视网膜病变患者的 38 只眼睛,在服用舒洛地特至少两年后进行随访。使用光学相干断层扫描测量眼底 CT,并对其进行前瞻性分析。评估了年龄、性别、糖尿病持续时间、HbA1c、血压、舒洛地特治疗时间、屈光不正、轴向长度、黄斑中心厚度(CMT)、视力、激光光凝和玻璃体内抗血管内皮生长因子注射等变量对 CT 的潜在影响。比较了基线时以及舒洛地特治疗后 6、12 和 24 个月时的 CMT、眼底 CT 和脉络膜血管指数:38只眼睛中,男性10只,女性28只。平均数据如下:年龄(67.18±8.87)岁;糖尿病病程(18.11±7.57)年;HbA1c(8.76±1.60)mmol/L;收缩压(134.69±14.68)mmHg;舒张压(73.72±11.90)mmHg;服用舒洛地特的时间(25.79±3.17)个月;屈光不正(0.22±2.19)屈光度(D);轴长(23.32±0.89)mm。在观察期间,15 只眼睛接受了激光光凝,17 只眼睛接受了玻璃体内抗血管内皮生长因子注射。服用舒洛地特前,平均眼底 CT 为 216.00 ± 64.23 μm,6、12 和 24 个月时分别增至 223.87 ± 62.18 μm、225.53 ± 62.02 μm、225.76 ± 63.62 μm(p = 0.0377、p = 0.0159、p = 0.0135)。CMT最初为318.14±102.28 μm,在上述时间间隔内分别变为313.08±77.47 μm、314.97±88.32 μm和320.03±97.36 μm,无显著变化(p = 0.904、p = 0.736、p = 0.892):结论:服用舒洛地特会导致眼底 CT 在两年的随访期间显著上升。结论:服用舒洛地特会导致眼底 CT 在 2 年的随访期间明显升高,而 CT 的这种变化并没有反映在 CMT 中。
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