Implications and Mechanisms of Antiviral Effects of Lactic Acid Bacteria: A Systematic Review

IF 2.8 Q3 MICROBIOLOGY International Journal of Microbiology Pub Date : 2023-12-12 DOI:10.1155/2023/9298363

Fargol Farahmnandi, P. Parhizgar, Parya Mozafari Komesh Tape, Fahimeh Bizhannia, Fateme Sadat Rohani, Marzieh Bizhanzadeh, Zeinab Sadat Mostafavi Alhosseini, Maede Hosseinzade, Yeganeh Farsi, M. Nasiri

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Abstract

Background. Lactic acid bacteria (LAB) are among the most important strains of probiotics. Some are normal flora of human mucous membranes in the gastrointestinal system, skin, urinary tract, and genitalia. There is evidence suggesting that LAB has an antiviral effect on viral infections. However, these studies are still controversial; a systematic review was conducted to evaluate the antiviral effects of LAB on viral infections. Methods. The systematic search was conducted until the end of December 17, 2022, using international databases such as Scopus, Web of Science, and Medline (via PubMed). The keywords of our search were lactic acid bacteria, Lactobacillales, Lactobacillus (as well as its species), probiotics, antiviral, inhibitory effect, and virus. Results. Of 15.408 potentially relevant articles obtained, 45 eligible in-vivo human studies were selected for inclusion in the study from databases, registers, and citation searching. We conducted a systematic review of the antiviral effects of the LAB based on the included articles. The most commonly investigated lactobacillus specie were Lactobacillus rhamnosus GG and Lactobacillus casei. Conclusion. Our study indicates that 40 of the selected 45 of the included articles support the positive effect of LAB on viral infections, although some studies showed no significant positive effect of LABs on some viral infections.

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乳酸菌抗病毒作用的意义和机制：系统综述

背景。乳酸菌（LAB）是益生菌中最重要的菌种之一。其中一些是人体胃肠道系统、皮肤、泌尿道和生殖器黏膜的正常菌群。有证据表明，LAB 对病毒感染有抗病毒作用。然而，这些研究仍存在争议；我们进行了一项系统性回顾，以评估 LAB 对病毒感染的抗病毒作用。方法。利用 Scopus、Web of Science 和 Medline（通过 PubMed）等国际数据库进行了系统性检索，直至 2022 年 12 月 17 日结束。搜索关键词为乳酸菌、乳杆菌科、乳杆菌（及其种类）、益生菌、抗病毒、抑制作用和病毒。结果。在获得的 15 408 篇潜在相关文章中，我们从数据库、登记册和引文检索中筛选出 45 项符合条件的体内人体研究纳入研究。我们根据纳入的文章对乳酸菌的抗病毒作用进行了系统性回顾。最常研究的乳酸杆菌是鼠李糖乳杆菌 GG 和干酪乳杆菌。结论我们的研究表明，在所选的 45 篇文章中，有 40 篇文章支持 LAB 对病毒感染有积极作用，尽管有些研究表明 LAB 对某些病毒感染没有明显的积极作用。

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来源期刊

International Journal of Microbiology MICROBIOLOGY-

CiteScore

7.90

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： International Journal of Microbiology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on microorganisms and their interaction with hosts and the environment. The journal covers all microbes, including bacteria, fungi, viruses, archaea, and protozoa. Basic science will be considered, as well as medical and applied research.