Laboratory Tests for the Early Detection of Adverse Drug Reaction

Abstract

The Food and Drug Administration (FDA) of the United States has approved drugs for sale in the country only if they are both safe and effective, meaning that the advantages of the medication must outweigh any known hazards. But over-the-counter (OTC) and prescription medications also have negative effects. (FDA) reactions, sometimes referred to as side effects, are undesired side effects that may be connected to a medication. Side effects can range in severity from little issues like a runny nose to potentially fatal situations like heart attack and in some case may lead to death. Age, use of other drugs, vitamins, or diet supplement, amount of drug, and route of administration can affect on degree of side effect as in IM or IV adverse effect is faster and stronger to appear than in oral route. According to laboratory tests, many tests have been done to detect impact of drug on body. In drugs cause liver failure tests appear elevated in liver enzyme as alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST). In kidney failure laboratory test indicate elevated in lipase and amylase serum.in drugs high cholesterol level such beta blocker, prednisone, and anabolic steroid in lab test detect high cholesterol level above 200mg\dl. Drugs elevate blood glucose as statins, corticosteroid, and beta blocker indicated elevation of blood glucose level above the normal. Analytical methods can consider also laboratory method as have been done in labs, it help in identification and separation of drugs so identify the drug these analytical method as spectrophotometry, gas chromatography, high performance liquid chromatography (HPLC).