Mechanisms of integration in psychedelic-assisted therapy

IF 0.7 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Military, Veteran and Family Health Pub Date : 2023-12-01 DOI:10.3138/jmvfh-2023-0014
N. Coverdale, Douglas J. Cook
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Abstract

LAY SUMMARY Psychedelic pharmacotherapies combined with structured psychotherapy have shown promise in the treatment of several psychological conditions. This type of therapy is known as psychedelic-assisted psychotherapy (PAP) and includes three phases: preparation, in-session support, and integration. The purpose of this review was to identify randomized controlled trials (RCTs) that used psychedelics to treat a psychological condition and to summarize the literature on changes that may be associated with clinical outcomes, as measured with MRI and various psychologically based tools. Psychedelics were administered in 17 RCTs, and 16 of these did so within a PAP framework. A total of 19 studies were identified that looked at MRI or psychological outcomes during the integration phase. Changes in brain networks during integration were identified but were not consistent between studies because of small sample sizes and inconsistent methodology. Some evidence suggests that changes in the executive control network may occur after psychedelic administration. Psychological changes after psychedelic administration were related to cognitive flexibility and personality traits such as openness and neuroticism. Overall, studies in this field should be repeated with a greater number of participants and other MRI-based techniques.
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迷幻药辅助疗法的整合机制
摘要 将迷幻药物疗法与结构化心理疗法相结合,在治疗多种心理疾病方面大有可为。这种疗法被称为迷幻药辅助心理疗法(PAP),包括三个阶段:准备、会话支持和整合。本综述旨在确定使用迷幻剂治疗某种心理疾病的随机对照试验(RCT),并总结通过核磁共振成像和各种心理学工具测量的、可能与临床结果相关的变化文献。有 17 项临床试验使用了迷幻剂,其中 16 项是在 PAP 框架内使用的。共有 19 项研究对整合阶段的核磁共振成像或心理结果进行了研究。研究发现了整合期间大脑网络的变化,但由于样本量较小和研究方法不一致,这些变化在不同的研究中并不一致。一些证据表明,服用迷幻药后,执行控制网络可能会发生变化。服用迷幻药后的心理变化与认知灵活性以及开放性和神经质等人格特征有关。总体而言,这一领域的研究应该使用更多的参与者和其他基于核磁共振成像的技术来重复进行。
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来源期刊
CiteScore
1.60
自引率
11.10%
发文量
72
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