Nicotinamide Mononucleotide in the Context of Myocardiocyte Longevity.

Basheer Abdullah Marzoog
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Abstract

Cellular and subcellular metabolic activities are crucial processes involved in the regulation of intracellular homeostasis, including cellular and subcellular signaling pathways. Dysregulation of intracellular regulation mechanisms is catastrophic and cumulates into cell death. To overcome the issue of dysregulation of intracellular regulation mechanisms, the preservation of subcellular and extracellular components is essential to maintain healthy cells with increased longevity. Several physiopathological changes occur during cell ageing, one of which is the dysregulation of intracellular physiology of the oxidative phosphorylation process. Nicotinamide mononucleotide (NMN) remains in the debut of anti-aging therapeutic effect. Aged myocardiocyte characterized by disrupted NMN and or its precursors or signaling pathways. Simultaneously, several other pathophysiological occur that collectively impair intracellular homeostasis. The NMN role in the antiaging effect remains unclear and several hypotheses have been introduced into describing the mechanism and the potential outcomes from NMN exogenous supply. Correction of the impaired intracellular homeostasis includes correction to the NMN metabolism. Additionally, autophagy correction, which is the key element in the regulation of intracellular intoxication, including oxidative stress, unfolding protein response, and other degradation of intracellular metabolites. Several signaling pathways are involved in the regulation mechanism of NMN effects on myocardiocyte health and further longevity. NMN protects myocardiocytes from ischemic injury by reducing anabolism and, increasing catabolism and further passing the myocardiocytes into dormant status. NMN applications include ischemic heart, disease, and failed heart, as well as dilated cardiomyopathies. Cytosolic and mitochondrial NADPH are independently functioning and regulating. Each of these plays a role in the determination of the longevity of the myocardiocytes. NMN has a cornerstone in the functionality of Sirtuins, which are an essential anti-senescent intrinsic molecule. The study aims to assess the role of NMN in the longevity and antisenescent of myocardiocytes.

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心肌细胞寿命背景下的烟酰胺单核苷酸
细胞和亚细胞代谢活动是调节细胞内平衡的关键过程,包括细胞和亚细胞信号通路。细胞内调节机制失调是灾难性的,会导致细胞死亡。要解决细胞内调节机制失调的问题,就必须保护亚细胞和细胞外成分,以保持细胞健康并延长其寿命。细胞老化过程中会发生几种生理病理变化,其中之一就是氧化磷酸化过程的细胞内生理失调。烟酰胺单核苷酸(NMN)仍然是抗衰老治疗效果的首次亮相。衰老心肌细胞的特点是 NMN 及其前体或信号通路紊乱。与此同时,其他一些病理生理现象也会共同损害细胞内的平衡。NMN 在抗衰老效应中的作用仍不明确,已有几种假设用于描述 NMN 外源供应的机制和潜在结果。纠正受损的细胞内稳态包括纠正 NMN 代谢。此外,自噬纠正是调节细胞内中毒的关键因素,包括氧化应激、折叠蛋白反应和细胞内代谢物的其他降解。NMN 对心肌细胞健康和进一步延年益寿的调节机制涉及多个信号通路。NMN 通过减少合成代谢、增加分解代谢和进一步使心肌细胞进入休眠状态,保护心肌细胞免受缺血性损伤。NMN 的应用包括缺血性心脏、疾病、衰竭性心脏以及扩张型心肌病。细胞质和线粒体中的 NADPH 具有独立的功能和调节作用。它们各自在决定心肌细胞寿命方面发挥作用。NMN 是 Sirtuins 功能的基石,而 Sirtuins 是一种重要的抗衰老内在分子。本研究旨在评估 NMN 在心肌细胞长寿和抗衰老方面的作用。
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来源期刊
Current aging science
Current aging science Medicine-Geriatrics and Gerontology
CiteScore
3.90
自引率
0.00%
发文量
40
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