Aptamer-functionalized MOFs and AI-driven strategies for early cancer diagnosis and therapeutics.

IF 2 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology Letters Pub Date : 2024-02-01 Epub Date: 2023-12-28 DOI:10.1007/s10529-023-03454-z

Abhishek Futane, Pramod Jadhav, Abu Hasnat Mustafa, Arthi Srinivasan, Vigneswaran Narayanamurthy

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Abstract

Metal-Organic Frameworks (MOFs) have exceptional inherent properties that make them highly suitable for diverse applications, such as catalysis, storage, optics, chemo sensing, and biomedical science and technology. Over the past decades, researchers have utilized various techniques, including solvothermal, hydrothermal, mechanochemical, electrochemical, and ultrasonic, to synthesize MOFs with tailored properties. Post-synthetic modification of linkers, nodal components, and crystallite domain size and morphology can functionalize MOFs to improve their aptamer applications. Advancements in AI and machine learning led to the development of nonporous MOFs and nanoscale MOFs for medical purposes. MOFs have exhibited promise in cancer therapy, with the successful accumulation of a photosensitizer in cancer cells representing a significant breakthrough. This perspective is focused on MOFs' use as advanced materials and systems for cancer therapy, exploring the challenging aspects and promising features of MOF-based cancer diagnosis and treatment. The paper concludes by emphasizing the potential of MOFs as a transformative technology for cancer treatment and diagnosis.

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用于早期癌症诊断和治疗的 Aptamer 功能化 MOFs 和人工智能驱动战略。

金属有机框架（MOFs）具有优异的固有特性，因此非常适合催化、存储、光学、化学传感以及生物医学科学与技术等多种应用领域。过去几十年来，研究人员利用溶热、水热、机械化学、电化学和超声波等各种技术合成了具有定制特性的 MOFs。通过对连接体、节点成分、晶粒畴尺寸和形态进行合成后修饰，可以对 MOFs 进行功能化，从而改善其适配体的应用。人工智能和机器学习的进步推动了用于医疗目的的无孔 MOFs 和纳米级 MOFs 的发展。MOFs 在癌症治疗方面大有可为，成功地在癌细胞中积累光敏剂是一项重大突破。本视角主要关注 MOFs 作为先进材料和系统在癌症治疗中的应用，探讨基于 MOFs 的癌症诊断和治疗所面临的挑战和具有前景的特点。论文最后强调了 MOFs 作为癌症治疗和诊断变革性技术的潜力。

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来源期刊

Biotechnology Letters 工程技术-生物工程与应用微生物

CiteScore

5.90

自引率

3.70%

发文量

108

审稿时长

1.2 months

期刊介绍： Biotechnology Letters is the world’s leading rapid-publication primary journal dedicated to biotechnology as a whole – that is to topics relating to actual or potential applications of biological reactions affected by microbial, plant or animal cells and biocatalysts derived from them. All relevant aspects of molecular biology, genetics and cell biochemistry, of process and reactor design, of pre- and post-treatment steps, and of manufacturing or service operations are therefore included. Contributions from industrial and academic laboratories are equally welcome. We also welcome contributions covering biotechnological aspects of regenerative medicine and biomaterials and also cancer biotechnology. Criteria for the acceptance of papers relate to our aim of publishing useful and informative results that will be of value to other workers in related fields. The emphasis is very much on novelty and immediacy in order to justify rapid publication of authors’ results. It should be noted, however, that we do not normally publish papers (but this is not absolute) that deal with unidentified consortia of microorganisms (e.g. as in activated sludge) as these results may not be easily reproducible in other laboratories. Papers describing the isolation and identification of microorganisms are not regarded as appropriate but such information can be appended as supporting information to a paper. Papers dealing with simple process development are usually considered to lack sufficient novelty or interest to warrant publication.