{"title":"Development of quercetin loaded silk fibroin/soybean protein isolate hydrogels for burn wound healing","authors":"Junyao Li, Yantao Li, Chuanlong Guo, Xiaochen Wu","doi":"10.1016/j.cej.2023.148458","DOIUrl":null,"url":null,"abstract":"<div><p>Hydrogel networks composed of naturally derived polymers offer a promising solution for the development of wound dressings due to their biodegradable, biocompatible, and renewable properties. In this study, silk fibroin (SF) and soybean protein isolate (SPI) were used as the main components to create a natural SF/SPI hydrogel. To further enhance its bioactivity, quercetin was loaded into the hydrogel to form a SF/SPI-Q hydrogel. The resulting SF/SPI-Q hybrid hydrogels possessed a unique combination of advantages derived from both the natural polymers (such as excellent biocompatibility, biodegradability, and promotion of cell migration) and therapeutic drugs (including antibacterial properties and antioxidant capacity). As a result, the hydrogel effectively accelerated wound healing in an infected burn wound model. The SF/SPI-Q hydrogels accelerated epidermal regeneration, collagen deposition, and angiogenesis, facilitating the healing process of burn wounds. Moreover, they also exhibited anti-inflammatory properties, which contributed to a reduction in inflammation. Thus, the SF/SPI-Q hydrogels showed great potential as a highly effective treatment option for wound healing applications.</p></div>","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":null,"pages":null},"PeriodicalIF":13.3000,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Engineering Journal","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1385894723071905","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Hydrogel networks composed of naturally derived polymers offer a promising solution for the development of wound dressings due to their biodegradable, biocompatible, and renewable properties. In this study, silk fibroin (SF) and soybean protein isolate (SPI) were used as the main components to create a natural SF/SPI hydrogel. To further enhance its bioactivity, quercetin was loaded into the hydrogel to form a SF/SPI-Q hydrogel. The resulting SF/SPI-Q hybrid hydrogels possessed a unique combination of advantages derived from both the natural polymers (such as excellent biocompatibility, biodegradability, and promotion of cell migration) and therapeutic drugs (including antibacterial properties and antioxidant capacity). As a result, the hydrogel effectively accelerated wound healing in an infected burn wound model. The SF/SPI-Q hydrogels accelerated epidermal regeneration, collagen deposition, and angiogenesis, facilitating the healing process of burn wounds. Moreover, they also exhibited anti-inflammatory properties, which contributed to a reduction in inflammation. Thus, the SF/SPI-Q hydrogels showed great potential as a highly effective treatment option for wound healing applications.
期刊介绍:
The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.