Advances in extracellular vesicles as mediators of cell-to-cell communication in pregnancy

IF 9.3 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine & Growth Factor Reviews Pub Date : 2023-12-29 DOI:10.1016/j.cytogfr.2023.12.004
Soumyalekshmi Nair , Melissa Razo-Azamar , Nanthini Jayabalan , Louise Torp Dalgaard , Berenice Palacios-González , Anne Sørensen , Ulla Kampmann , Aase Handberg , Flavio Carrion , Carlos Salomon
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Abstract

Cell-to-cell communication mediated by Extracellular Vesicles (EVs) is a novel and emerging area of research, especially during pregnancy, in which placenta derived EVs can facilitate the feto-maternal communication. EVs comprise a heterogeneous group of vesicle sub-populations with diverse physical and biochemical characteristics and originate by specific biogenesis mechanisms. EVs transfer molecular cargo (including proteins, nucleic acids, and lipids) between cells and are critical mediators of cell communication. There is growing interest among researchers to explore into the molecular cargo of EVs and their functions in a physiological and pathological context. For example, inflammatory mediators such as cytokines are shown to be released in EVs and EVs derived from immune cells play key roles in mediating the immune response as well as immunoregulatory pathways. Pregnancy complications such as gestational diabetes mellitus, preeclampsia, intrauterine growth restriction and preterm birth are associated with altered levels of circulating EVs, with differential EV cargo and bioactivity in target cells. This implicates the intriguing roles of EVs in reprogramming the maternal physiology during pregnancy. Moreover, the capacity of EVs to carry bioactive molecules makes them a promising tool for biomarker development and targeted therapies in pregnancy complications. This review summarizes the physiological and pathological roles played by EVs in pregnancy and pregnancy-related disorders and describes the potential of EVs to be translated into clinical applications in the diagnosis and treatment of pregnancy complications.

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细胞外小泡作为妊娠期细胞间通讯媒介的研究进展
由细胞外囊泡(EVs)介导的细胞间通讯是一个新兴的研究领域,尤其是在怀孕期间,胎盘衍生的EVs可促进胎儿与母体之间的通讯。EVs由一组异质的囊泡亚群组成,具有不同的物理和生化特征,并通过特定的生物生成机制产生。EVs 在细胞间传递分子货物(包括蛋白质、核酸和脂质),是细胞通讯的关键媒介。研究人员对 EVs 分子货物及其在生理和病理环境中功能的探索兴趣与日俱增。例如,细胞因子等炎症介质被证明会在 EVs 中释放,来自免疫细胞的 EVs 在介导免疫反应和免疫调节途径中发挥着关键作用。妊娠并发症,如妊娠糖尿病、先兆子痫、宫内生长受限和早产,都与循环中 EVs 水平的改变有关,靶细胞中的 EV 货物和生物活性也各不相同。这表明,EVs 在孕期重塑母体生理机能方面发挥着重要作用。此外,EVs 携带生物活性分子的能力使其成为开发妊娠并发症生物标志物和靶向治疗的一种有前途的工具。本综述总结了EVs在妊娠和妊娠相关疾病中发挥的生理和病理作用,并描述了EVs在诊断和治疗妊娠并发症方面转化为临床应用的潜力。
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来源期刊
Cytokine & Growth Factor Reviews
Cytokine & Growth Factor Reviews 生物-生化与分子生物学
CiteScore
21.10
自引率
1.50%
发文量
61
审稿时长
22 days
期刊介绍: Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.
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