MACHINE LEARNING ENABLES QUANTIFYING CELL-JANUS PARTICLE CONJUGATES THROUGH MICROFLOWING IMPEDANCE SIGNALS.

Abstract

In this work, we demonstrate the differentiation of demodulated multifrequency signals from impedance sensitive microparticles when targeting surface receptors on neutrophils in a microfluidic impedance cytometer. These scheme uses a single signal input and detection configuration, and machine learning can differentiate particle types with up to 82% accuracy.