Diverse Endotypes of Chronic Rhinosinusitis and Clinical Implications.

IF 8.4 2区 医学 Q1 ALLERGY Clinical Reviews in Allergy & Immunology Pub Date : 2023-12-01 Epub Date: 2024-01-04 DOI:10.1007/s12016-023-08976-y
Xiran Xie, Lijia Xuan, Yajuan Zhao, Xiangdong Wang, Luo Zhang
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Abstract

Chronic rhinosinusitis (CRS) is a highly heterogeneous disease characterized by inflammation in the nasal and sinus mucosa. The CRS phenotypes, based on the presence or absence of nasal polyps, are known as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). However, this classification has limitations in fully capturing the mechanisms and clinical manifestations of CRS. To address the heterogeneity of CRS, there has been a growing focus on classifying the condition into distinct endotypes. Endotype classification involves grouping patients based on specific molecular, immunological, and clinical characteristics, allowing for more personalized and targeted treatment approaches.This review delves into the current state of endotype classifications for CRS. It explores the role of geographic factors, microbiome, and subphenotype in shaping different endotypes. Additionally, the review examines how various clinical features are associated with specific endotypes, providing valuable insights into tailoring treatment options for better outcomes and transitions between different endotypes.Overall, this review offers a comprehensive and up-to-date perspective on the intricate realm of CRS endotype classifications. By unraveling the molecular and clinical intricacies, this review lays the foundation for more precise, effective, and individualized treatment strategies in the management of CRS.

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慢性鼻炎的多种内型及其临床意义。
慢性鼻窦炎(CRS)是一种以鼻腔和鼻窦粘膜炎症为特征的高度异质性疾病。根据是否存在鼻息肉,CRS 的表型被称为有鼻息肉的 CRS(CRSwNP)和无鼻息肉的 CRS(CRSsNP)。然而,这种分类方法在全面反映 CRS 的发病机制和临床表现方面存在局限性。为了解决 CRS 的异质性问题,越来越多的人开始关注将这种疾病分为不同的内型。内型分类是指根据特定的分子、免疫学和临床特征对患者进行分组,使治疗方法更具个性化和针对性。它探讨了地理因素、微生物组和亚表型在形成不同内型中的作用。此外,这篇综述还探讨了各种临床特征如何与特定内型相关联,为定制治疗方案以获得更好的疗效以及不同内型之间的转换提供了有价值的见解。总之,这篇综述为 CRS 内型分类的复杂领域提供了全面、最新的视角。通过揭示分子和临床的复杂性,这篇综述为更精确、有效和个体化的 CRS 治疗策略奠定了基础。
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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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