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Clinical Reviews in Allergy & Immunology最新文献

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Unmasking the Impact of Air Pollution on Allergic Rhinitis. 揭示空气污染对变应性鼻炎的影响。
IF 11.3 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology
Pub Date : 2026-03-24 DOI: 10.1007/s12016-026-09155-5
Yingyang Xu, Xiaohong Lyu, Yongshi Yang, Nicole Akar-Ghibril, Marta Telatin, Rui Tang, Christopher Chang, Jinlyu Sun
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引用次数: 0
Mouse Models of Food Allergies: Where Do They Take Us? 食物过敏的小鼠模型：它们将我们带向何方？
IF 11.3 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology
Pub Date : 2026-03-24 DOI: 10.1007/s12016-026-09146-6
Shanshan Li, Zhanling Liang, Muhammad Mazhar, Yun Liao, Kin-Ming Kwan, Ping-Chang Yang, Ka-Hou Chu, Xiaoyu Liu, Xiaojun Xiao
{"title":"Mouse Models of Food Allergies: Where Do They Take Us?","authors":"Shanshan Li, Zhanling Liang, Muhammad Mazhar, Yun Liao, Kin-Ming Kwan, Ping-Chang Yang, Ka-Hou Chu, Xiaoyu Liu, Xiaojun Xiao","doi":"10.1007/s12016-026-09146-6","DOIUrl":"https://doi.org/10.1007/s12016-026-09146-6","url":null,"abstract":"","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"69 1","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving Therapeutic Strategies in ANCA-Associated Vasculitis: Current Standards and Emerging Targets for GPA and MPA. anca相关血管炎治疗策略的演变：GPA和MPA的现行标准和新目标。
IF 11.3 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology
Pub Date : 2026-03-23 DOI: 10.1007/s12016-026-09147-5
Roberto Dal Pozzolo, Luca Iorio, Federica Davanzo, Elisabetta Zanatta, Luca Iaccarino, Roberta Ramonda, Roberto Gerli, Andrea Doria, Giacomo Cafaro, Roberto Padoan
{"title":"Evolving Therapeutic Strategies in ANCA-Associated Vasculitis: Current Standards and Emerging Targets for GPA and MPA.","authors":"Roberto Dal Pozzolo, Luca Iorio, Federica Davanzo, Elisabetta Zanatta, Luca Iaccarino, Roberta Ramonda, Roberto Gerli, Andrea Doria, Giacomo Cafaro, Roberto Padoan","doi":"10.1007/s12016-026-09147-5","DOIUrl":"https://doi.org/10.1007/s12016-026-09147-5","url":null,"abstract":"","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"69 1","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conductive Mechanisms of Olfactory Dysfunction in Chronic Rhinosinusitis: A Focus on Nasal Airflow Dynamics and Olfactory Mucus. 慢性鼻窦炎嗅觉功能障碍的传导机制：鼻腔气流动力学和嗅觉粘液的研究
IF 11.3 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology
Pub Date : 2026-03-21 DOI: 10.1007/s12016-026-09149-3
Xincen Jiang, Lina Chen, Xingchen Pan, Yankun Li, Yinghong Zhang, Dawei Wu
{"title":"Conductive Mechanisms of Olfactory Dysfunction in Chronic Rhinosinusitis: A Focus on Nasal Airflow Dynamics and Olfactory Mucus.","authors":"Xincen Jiang, Lina Chen, Xingchen Pan, Yankun Li, Yinghong Zhang, Dawei Wu","doi":"10.1007/s12016-026-09149-3","DOIUrl":"10.1007/s12016-026-09149-3","url":null,"abstract":"","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"69 1","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Factors Associated with Genetically Confirmed Inborn Errors of Immunity in Children Presenting with Immune Dysregulation. 以免疫失调为表现的儿童中遗传证实的先天性免疫错误的临床因素
IF 11.3 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology
Pub Date : 2026-03-20 DOI: 10.1007/s12016-026-09148-4
Oksana Boyarchuk, Anna Hilfanova, Valery Petrova, Tetiana Kovalchuk, Jolan E Walter
{"title":"Clinical Factors Associated with Genetically Confirmed Inborn Errors of Immunity in Children Presenting with Immune Dysregulation.","authors":"Oksana Boyarchuk, Anna Hilfanova, Valery Petrova, Tetiana Kovalchuk, Jolan E Walter","doi":"10.1007/s12016-026-09148-4","DOIUrl":"https://doi.org/10.1007/s12016-026-09148-4","url":null,"abstract":"","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"69 1","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes. 嗜电性谷氨酸受体在白细胞中的矛盾表达。
IF 11.3 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology
Pub Date : 2026-03-19 DOI: 10.1007/s12016-025-09126-2
Felix I L Clanchy, Richard O Williams, Trevor W Stone
{"title":"Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes.","authors":"Felix I L Clanchy, Richard O Williams, Trevor W Stone","doi":"10.1007/s12016-025-09126-2","DOIUrl":"10.1007/s12016-025-09126-2","url":null,"abstract":"","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"69 1","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Application of Single-cell RNA Sequencing Technology in the Research of Sino-Nasal Diseases. 单细胞RNA测序技术在鼻疾病研究中的应用。
IF 11.3 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology
Pub Date : 2026-03-18 DOI: 10.1007/s12016-026-09145-7
Mingrui Pan, Zhuoran Jia, Min Zhou, Junhai Chen, Huijun Qiu, Xin Luo, Yana Zhang, Zhaohui Shi, Shuo Wu, Deyun Wang, Qintai Yang
{"title":"The Application of Single-cell RNA Sequencing Technology in the Research of Sino-Nasal Diseases.","authors":"Mingrui Pan, Zhuoran Jia, Min Zhou, Junhai Chen, Huijun Qiu, Xin Luo, Yana Zhang, Zhaohui Shi, Shuo Wu, Deyun Wang, Qintai Yang","doi":"10.1007/s12016-026-09145-7","DOIUrl":"https://doi.org/10.1007/s12016-026-09145-7","url":null,"abstract":"","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"69 1","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Roles of Interleukin-18 in Inflammation and Autoimmune Disease. 白细胞介素-18在炎症和自身免疫性疾病中的作用。
IF 11.3 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology
Pub Date : 2026-03-16 DOI: 10.1007/s12016-026-09139-5
Yue Zhao, Yuan Tang, Xiaoxia Zhu, Yunxia Hou, Hongbin Li, Francesco Ciccia, Hejian Zou, Liwei Lu

Interleukin-18 (IL-18) is a member of the IL-1 cytokine family with significant homology to IL-1β. New emerging evidence indicates that IL-18 acts as a pivotal molecular bridge connecting innate and adaptive immunity, functioning through tightly regulated mechanisms involving inflammasome-dependent and -independent proteolytic processing. The activity of IL-18 is primarily maintained by IL-18 binding protein (IL-18BP), which neutralizes IL-18 under physiological conditions. However, dysregulations in the IL-18/IL-18BP axis result in excessive IL-18 bioactivity, driving tissue inflammation and damage closely associated with autoimmune pathogenesis. Herein, we review recent advances in IL-18 biology and its expanding roles in the development of various autoimmune diseases. The molecular mechanisms by which IL-18 mediates organ-specific pathology are discussed to highlight its diverse effector functions across different autoimmune conditions. In addition, we evaluate emerging therapeutic approaches targeting the IL-18 pathway, with a focus on their potential and challenges in translational clinical research.

白细胞介素-18 （IL-18）是IL-1细胞因子家族的成员，与IL-1β具有显著的同源性。新出现的证据表明，IL-18作为连接先天免疫和适应性免疫的关键分子桥梁，通过涉及炎性小体依赖性和非依赖性蛋白水解加工的严格调节机制发挥作用。IL-18的活性主要由IL-18结合蛋白（IL-18BP）维持，该蛋白在生理条件下中和IL-18。然而，IL-18/IL-18BP轴的失调导致IL-18生物活性过高，驱动与自身免疫发病密切相关的组织炎症和损伤。在此，我们回顾了IL-18生物学的最新进展及其在各种自身免疫性疾病发展中的作用。本文讨论了IL-18介导器官特异性病理的分子机制，以突出其在不同自身免疫性疾病中的不同效应功能。此外，我们评估了针对IL-18通路的新兴治疗方法，重点关注它们在转化临床研究中的潜力和挑战。
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引用次数: 0
Rising Tide of Crustacean Allergies in East Asia: a Comprehensive Review of Genetic Insights and Implications for Early Evaluation of Health Risks. 东亚甲壳类动物过敏症的上升趋势：对早期健康风险评估的遗传见解和意义的全面回顾。
IF 11.3 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology
Pub Date : 2026-03-07 DOI: 10.1007/s12016-026-09134-w
Shi-Tao Rao, Jian-Wei Jiang, Shuai Zhi, Jia-Han Que, Xin-Yu Han, Stephen Kwok-Wing Tsui, Guang-Ming Liu
{"title":"Rising Tide of Crustacean Allergies in East Asia: a Comprehensive Review of Genetic Insights and Implications for Early Evaluation of Health Risks.","authors":"Shi-Tao Rao, Jian-Wei Jiang, Shuai Zhi, Jia-Han Que, Xin-Yu Han, Stephen Kwok-Wing Tsui, Guang-Ming Liu","doi":"10.1007/s12016-026-09134-w","DOIUrl":"https://doi.org/10.1007/s12016-026-09134-w","url":null,"abstract":"","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"69 1","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Untangling the Complexity of Childhood Atopic Dermatitis: Phenotypes and Endotypes. 解开儿童特应性皮炎的复杂性：表型和内型。
IF 11.3 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology
Pub Date : 2026-03-02 DOI: 10.1007/s12016-025-09128-0
Karolina Dumycz, Joanna Zygadło, Aleksandra Marzec, Piotr Strus, Marek Kulus, Milena Sokolowska, Carina Venter, Donald Y M Leung, Wojciech Feleszko
{"title":"Untangling the Complexity of Childhood Atopic Dermatitis: Phenotypes and Endotypes.","authors":"Karolina Dumycz, Joanna Zygadło, Aleksandra Marzec, Piotr Strus, Marek Kulus, Milena Sokolowska, Carina Venter, Donald Y M Leung, Wojciech Feleszko","doi":"10.1007/s12016-025-09128-0","DOIUrl":"https://doi.org/10.1007/s12016-025-09128-0","url":null,"abstract":"","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"69 1","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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