Sex differences in development of functional connections in the face processing network

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY Journal of Neuroimaging Pub Date : 2024-01-02 DOI:10.1111/jon.13185

Duncan Nowling, Kathleen I. Crum, Jane Joseph

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Abstract

Background and Purpose

Understanding sex differences in typical development of the face processing network is important for elucidating disruptions during atypical development in sex-linked developmental disorders like autism spectrum disorder. Based on prior sex difference studies in other cognitive domains, this study examined whether females show increased integration of core and extended face regions with age for face viewing, while males would show increased segregation.

Methods

This study used a cross-sectional design with typically developing children and adults (n = 133) and a functional MRI face localizer task. Psychophysiological interaction (PPI) analysis examined functional connectivity between canonical and extended face processing network regions with age, with greater segregation indexed by decreased core-extended region connectivity with age and greater integration indexed by increased core-extended region connectivity with age.

Results

PPI analysis confirmed increased segregation for males—right fusiform face area (FFA) coupling to right inferior frontal gyrus (IFG) opercular when viewing faces and left amygdala when viewing objects decreased with age. Females showed increased integration with age (increased coupling of the right FFA to right IFG opercular region and right occipital face area [OFA] to right IFG orbital when viewing faces and objects, respectively) and increased segregation (decreased coupling with age of the right OFA with IFG opercular region when viewing faces).

Conclusions

Development of core and extended face processing network connectivity follows sexually dimorphic paths. These differential changes mostly occur across childhood and adolescence, with males experiencing segregation and females both segregation and integration changes in connectivity.

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面孔处理网络功能连接发展的性别差异。

背景和目的：了解人脸处理网络典型发育过程中的性别差异，对于阐明自闭症谱系障碍等与性别相关的发育障碍在非典型发育过程中出现的紊乱非常重要。基于之前在其他认知领域进行的性别差异研究，本研究探讨了女性在观看人脸时，是否会随着年龄的增长而显示出更多的核心和扩展人脸区域的整合，而男性则会显示出更多的分离：本研究采用横断面设计，研究对象为发育正常的儿童和成人（n = 133），并进行了功能磁共振成像人脸定位任务。心理生理学交互作用（PPI）分析检验了典型和扩展人脸处理网络区域之间随年龄变化的功能连接性，随着年龄的增长，核心-扩展区域连接性的降低表明分离性增强，而随着年龄的增长，核心-扩展区域连接性的增强表明整合性增强：PPI分析证实，男性的分离度随年龄的增长而增加--观察人脸时，右侧纺锤形面区（FFA）与右侧额叶下回（IFG）厣的耦合度随年龄的增长而增加；观察物体时，左侧杏仁核的耦合度随年龄的增长而减少。女性的整合性随着年龄的增长而增强（观看人脸和物体时，右侧 FFA 与右侧 IFG厣区的耦合性增强，右侧枕面部区 [OFA] 与右侧 IFG眶区的耦合性增强），分离性增强（观看人脸时，右侧 OFA 与 IFG厣区的耦合性随着年龄的增长而减弱）：结论：核心和扩展面孔处理网络连接的发展遵循性别二态性路径。这些差异变化主要发生在儿童期和青春期，男性经历分离，而女性则同时经历分离和整合的连通性变化。

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!