Journal of Neuroimaging最新文献

Background: Recent studies suggest that disruptions of the blood-cerebrospinal fluid (CSF) barrier within the choroid plexus (ChP) may contribute to multiple sclerosis (MS) pathogenesis. We investigated the relationship between a quantitative marker of ChP enhancement and markers of focal and diffuse brain tissue injury in MS.

Methods: A group of 34 MS participants and 21 healthy participants underwent 7T MRI including magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) and fluid attenuated inversion recovery (FLAIR) acquisitions. The MS group received contrast, and delta T1 (ΔT1) maps were computed to assess enhancement. ChP, white matter lesions (WML), normal-appearing white matter (NAWM), and gray matter (GM) were segmented. Pre-contrast quantitative T1 (qT1) values were compared between groups, and linear regression with mean ChP ΔT1 was performed for WML volume and pre-gadolinium (Gd) mean qT1 of WML, NAWM, and GM.

Results: Mean qT1 of ChP, NAWM, and GM, as well as ChP volume, were higher in MS compared to controls (p < 0.001). ChP ΔT1 was significantly associated with pre-Gd qT1 of NAWM (β = 0.20, R² = 0.54, p < 0.001) and GM (β = 0.18, R² = 0.49, p < 0.001), but not WML volume (p = 0.3) or WML qT1 (p = 0.05).

Conclusions: The association between ChP enhancement and diffuse tissue injury, together with elevated qT1 values and ChP volumes in MS, supports a mechanism of brain injury involving CSF-mediated toxicity distinct from classic lesion pathology in MS.

Background and purpose: We evaluated agreement and performance of non-contrast head-computerized tomography (NCHCT) and CT-perfusion (CTP) in identifying large core infarct in acute ischemic stroke (AIS) due to large vessel occlusion (LVO) undergoing endovascular therapy (EVT), using MRI as reference.

Methods: From our prospective multicenter registry, we identified patients with LVO-AIS due to internal carotid artery or middle cerebral artery M1occlusions who underwent EVT between 2017 and 2024. Final infarct volume (FIV) was defined using 24-48 h post-EVT diffusion-weighted imaging magnetic resonance imaging (MRI-FIV). To limit infarct growth bias, only patients with CTP-to-EVT start time <3 h were included. Large core infarct was defined at FIV thresholds: 50, 70, and 100 mL. The primary outcome was agreement between NCHCT and CTP in identifying large core infarct using kappa-statistics. Large core was considered if NCHCT-ASPECTS<6 or rCBF<30% volume>70 mL on CTP (RAPID/Viz.AI). Secondary outcomes included classification accuracy of each modality relative to MRI-FIV using the area under the receiver operating characteristic curve (AUC-ROC). Sensitivity analyses were performed in subgroups with TICI 2c-3 and cases processed by RAPID.

Results: Among 241 EVT-treated LVO-AIS patients, median NIHSS was 15 [IQR: 10-20], MRI-FIV 13.8 Ml [IQR: 5-41.0], ASPECTS 8 [IQR: 7-10], and CTP-predicted core 8 mL [IQR: 0-31.0]. CTP and NCHCT showed slight agreement in identifying large core (κ = 0.192) and weak-to-acceptable discrimination for identifying large core infarcts (AUC-ROC: 0.61-0.72 across MRI-FIV thresholds). Both modalities showed limited predictive ability for 90-day functional independence (AUC-ROC: 0.63-0.65). Similar findings were observed in sensitivity analyses.

Conclusions: Among LVO-AIS EVT-treated patients, NCHCT and CTP demonstrated slight agreement in classifying small versus large core, and neither technique was effective at predicting FIV or clinical outcomes.

Background: Facial nerve (CN VII) diffusion MR tractography is considered as a useful adjunct in pre-operative planning prior to vestibular schwannoma (VS) resection, especially in larger (Koos Grade III/IV) tumors. Since 2016, several systematic reviews have investigated the clinical value of CN VII tractography in VS, and all reported a "success rate" of at least 87% for predicting the pre-operative CN VII position. Yet in clinical practice, CN VII tractography has not yet been widely adopted into routine clinical practice. We suspected that underlying methodology and reporting metrics for existing tractography algorithms may be overestimating success rate. This motivated us to revisit the literature from a different perspective to unravel the caveats and nuances behind this technology.

Methods: We screened all published works on PubMed related to pre-operative CN VII tractography in VS. Twenty-two studies were reviewed in detail.

Results: We observed a strikingly high heterogeneity in tractography protocols in all domains of the tractography acquisition and analysis pipeline across studies.

Conclusions: These findings suggest that the reliability and reproducibility of CN VII tractography in large VS has been overestimated. We believe that employing standardized reporting metrics, including sensitivity, true predictive value, and false discovery rate, would increase the transparency of benchmarking over other commonly reported metrics ("success rate" or "concordance rate"). In addition, ongoing research should aim to systematically investigate and improve each step in the acquisition and analysis pipeline for CN VII tractography in VS.

Y. Ota, E. Liao, R. Kurokawa, et al., “Diffusion-Weighted and Dynamic Contrast-Enhanced MRI to Assess Radiation Therapy Response for Head and Neck Paragangliomas,” Journal of Neuroimaging 31, no. 5 (2021): 1035-1043, https://doi.org/10.1111/jon.12875.

The above article, published online on 18 May 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Rohit Bakshi; American Society of Neuroimaging; and John Wiley & Sons, Inc. The retraction has been agreed upon following an investigation conducted by the University of Michigan. The investigation determined that the patient exclusion criteria described in the article were not followed during the study. Furthermore, the age and sex of three patients were inaccurately described in relation to the figures presented. The authors explained that although one patient technically met the exclusion criteria, the authors included this case based on their interpretation that prior interventions did not affect the intracranial lesions analyzed. They also acknowledged that the age and sex of three patients were inaccurately described. The editors concluded that the explanation provided was insufficient to restore confidence in the results and conclusions of the study. E. Liao, R. Kurokawa, F. Syed, A. Baba, M. Kurokawa, and A. Srinivasan agreed to the retraction. The remaining authors could not be reached for final confirmation.

Y. Ota, E. Liao, A. A. Capizzano, et al., “Intracranial Paragangliomas Versus Schwannomas: Role of Dynamic Susceptibility Contrast Perfusion and Diffusion MRI,” Journal of Neuroimaging 32, no. 5 (2022): 875-883, https://doi.org/10.1111/jon.13002.

The above article, published online on 12 May 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Rohit Bakshi; American Society of Neuroimaging; and John Wiley & Sons, Inc. The retraction has been agreed upon following an investigation conducted by the University of Michigan. The investigation determined that the patient inclusion and exclusion criteria described in the article were not followed during the study. Duplication and reuse of data from three individual patients were also identified. The authors stated that the study variables were unaffected by the conditions outlined in the exclusion criteria. However, as the first author left the institute and was unresponsive, the co-authors and the journal could not obtain original data for further investigation or verification of the results. As a result, the editors consider the study's results and conclusions unreliable. The authors, E. Liao, A. A. Capizzano, A. Baba, R. Kurokawa, M. Kurokawa, and A. Srinivasan agree to the retraction. Acknowledgement of the retraction could not be obtained from Y. Ota.

Y. Ota, E. Liao, A.A. Capizzano, et al., “MR Diffusion and Dynamic-Contrast Enhanced Imaging to Distinguish Meningioma, Paraganglioma, and Schwannoma in the Cerebellopontine Angle and Jugular Foramen,” Journal of Neuroimaging 32, no. 3 (2022): 502-510, https://doi.org/10.1111/jon.12959.

The above article, published online on 22 December 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Rohit Bakshi; American Society of Neuroimaging; and John Wiley & Sons, Inc. The retraction has been agreed upon following an investigation conducted by the University of Michigan. The investigation identified duplication and reuse of data from three individual patients within the study. The authors were invited to comment on the concerns raised and provide supporting data. However, as the first author left the institute and was unresponsive, the co-authors and the journal could not obtain original data for further investigation or verification of the results. The editors consider the results and conclusions of the study unreliable. The authors, E. Liao, A.A. Capizzano, H. Yokota, A. Baba, R. Kurokawa, M. Kurokawa, K. Yoshii, and A. Srinivasan agree to the retraction. The remaining authors could not be reached for final confirmation.

Y. Ota, E. Liao, A.A. Capizzano, A. Baba, R. Kurokawa, M. Kurokawa, and A. Srinivasan, “Neurofibromatosis Type 2 Versus Sporadic Vestibular Schwannoma: The Utility of MR Diffusion and Dynamic Contrast-Enhanced Imaging,” Journal of Neuroimaging 32, no. 3 (2022): 554-560, https://doi.org/10.1111/jon.12966.

The above article, published online on 17 January 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Rohit Bakshi; American Society of Neuroimaging; and John Wiley & Sons, Inc. The retraction has been agreed upon following an investigation conducted by the University of Michigan. The investigation determined that the patient exclusion criteria described in the article were not followed during the study. Duplication and reuse of data from three individual patients were also identified. The authors acknowledged that one patient who should have been excluded under these criteria was included in the study. However, as the first author left the institute and was unresponsive, the co-authors and the journal could not obtain original data for further investigation or verification of the results. As a result, the editors consider the study's results and conclusions unreliable. The authors, E. Liao, A.A. Capizzano, A. Baba, R. Kurokawa, M. Kurokawa, and A. Srinivasan agree to the retraction. Acknowledgement of the retraction could not be obtained from Y. Ota.

Y. Ota, E. Liao, R. Zhao, et al., “Advanced MRI to Differentiate Schwannomas and Metastases in the Cerebellopontine Angle/Internal Auditory Canal,” Journal of Neuroimaging 32, no. 6 (2022): 1177-1184, https://doi.org/10.1111/jon.13028.

The above article, published online on 25 July 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Rohit Bakshi; American Society of Neuroimaging; and John Wiley & Sons, Inc. The retraction has been agreed upon following an investigation conducted by the University of Michigan. The investigation identified duplication and reuse of data from four individual patients within the study. The authors were invited to comment on the concerns raised and provide supporting data. However, as the first author left the institute and was unresponsive, the co-authors and the journal could not obtain original data for further investigation or verification of the results. The editors consider the results and conclusions of the study unreliable. The authors, E. Liao, R. Lobo, A.A. Capizzano, J.R. Bapuraj, G. Shah, and A. Srinivasan, agreed to the retraction. The remaining authors did not respond to the retraction notice.