A case of rheumatoid arthritis in a Nubian woman from the site of Sheikh Mohamed, near Aswan, Egypt

IF 1.3 3区地球科学 Q3 PALEONTOLOGY International Journal of Paleopathology Pub Date : 2024-01-03 DOI:10.1016/j.ijpp.2023.12.003

Madeleine Mant , Mindy C. Pitre , Sarah Dancer , Maria Carmela Gatto

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Abstract

Objective

To differentially diagnose and contextualize pathological lesions suggestive of rheumatoid arthritis.

Materials

The skeletal remains of a 25–30-year-old female dated to c. 1750–1550 BCE from a Nubian Pan-Grave cemetery at the site of Sheik Mohamed, near Aswan, Egypt.

Methods

The skeletal remains were examined macroscopically and a differential diagnosis was conducted following established protocols in the palaeopathological literature.

Results

Symmetrical, bilateral, erosive periarticular lesions with smooth edges were observed in multiple joints (especially in the hands and feet).

Conclusions

Differential diagnosis suggests this individual had rheumatoid arthritis.

Significance

This case suggests the presence of rheumatoid arthritis in ancient Egypt, contributing to a more finely grained understanding of the antiquity and geographical distribution of the condition.

Limitations

It was not possible to radiograph the skeletal remains.

Suggestions for further research

Researchers are encouraged to re-examine any archaeological examples of erosive polyarthropathy using current palaeopathological protocols and to explore the manifestation of rheumatoid arthritis on the African continent.

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埃及阿斯旺附近谢赫-穆罕默德遗址的一例努比亚妇女类风湿性关节炎病例。

目的材料：埃及阿斯旺附近谢克-穆罕默德（Sheik Mohamed）遗址出土的 25-30 岁女性骸骨，年代约为公元前 1750-1550 年：一名 25-30 岁女性的遗骸，年代约为公元前 1750-1550 年，来自埃及阿斯旺附近谢克-穆罕默德遗址的努比亚泛墓地：对遗骸进行了宏观检查，并根据古病理学文献中的既定方案进行了鉴别诊断：结果：在多个关节（尤其是手部和足部）观察到对称、双侧、边缘光滑的侵蚀性关节周围病变：鉴别诊断表明该患者患有类风湿性关节炎：该病例表明古埃及存在类风湿性关节炎，有助于更深入地了解该疾病的历史和地理分布：局限性：无法对骨骼遗骸进行射线照相：鼓励研究人员使用当前的古病理学方法重新研究侵蚀性多关节病的考古实例，并探索类风湿关节炎在非洲大陆的表现形式。

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来源期刊

International Journal of Paleopathology PALEONTOLOGY-PATHOLOGY

CiteScore

2.90

自引率

25.00%

发文量

期刊介绍： Paleopathology is the study and application of methods and techniques for investigating diseases and related conditions from skeletal and soft tissue remains. The International Journal of Paleopathology (IJPP) will publish original and significant articles on human and animal (including hominids) disease, based upon the study of physical remains, including osseous, dental, and preserved soft tissues at a range of methodological levels, from direct observation to molecular, chemical, histological and radiographic analysis. Discussion of ways in which these methods can be applied to the reconstruction of health, disease and life histories in the past is central to the discipline, so the journal would also encourage papers covering interpretive and theoretical issues, and those that place the study of disease at the centre of a bioarchaeological or biocultural approach. Papers dealing with historical evidence relating to disease in the past (rather than history of medicine) will also be published. The journal will also accept significant studies that applied previously developed techniques to new materials, setting the research in the context of current debates on past human and animal health.