Integrative vision in cancer research, prevention and therapy

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Ayurveda and Integrative Medicine Pub Date : 2024-01-01 DOI:10.1016/j.jaim.2023.100856

Ashok DB. Vaidya M.D.,Ph.D.

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Abstract

There is already a significant global initiative to explore the synergy between traditional medicine (TM) and oncology, for holistic best care of cancer patients. Integrative oncology clinics have emerged with operational efficiency. What is needed now is an integrative vision that inspires to seamlessly coordinate the trans-system efforts in cancer research and rapidly translate the positive outcomes into prevention and treatment of cancer. The current dominant paradigm to consider TM only for complementary and alternative adjunct usage cannot inspire state-of-the art research and development on TM leads and serendipitous discoveries. Ayurvedic concepts of Vyadhi-kshamatwa (Immune resistance), Shatkriyakala (Six stages of a disease) and Hetuviparya Chikitsa (Reversal of pathogenetic factors) need to be synergized with ayurvedic pharmacoepidemiology, reverse pharmacology, observational therapeutics, ayurgenomics, ayurvedic biology, and reverse ayurceutics. Such a paradigm-shifting vision may lead to pragmatic translational research/practice and system obstacles and novel bridges in Integrative Oncology.

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癌症研究、预防和治疗的综合视角。

在全球范围内，已经有很多人开始探索传统医学（TM）与肿瘤学之间的协同作用，以便为癌症患者提供全面的最佳治疗。中西医结合肿瘤诊所已经出现，并取得了良好的运营效果。现在需要的是一种综合性的愿景，它能激发人们无缝协调癌症研究中的跨系统工作，并迅速将积极成果转化为癌症预防和治疗。目前的主流模式认为 TM 仅用于补充和替代辅助用途，这无法激发对 TM 线索和偶然发现的最新研究和开发。阿育吠陀的 Vyadhi-kshamatwa（免疫抗性）、Shatkriyakala（疾病的六个阶段）和 Hetuviparya Chikitsa（致病因素的逆转）概念需要与阿育吠陀药物流行病学、逆向药理学、观察治疗学、阿育吠陀基因组学、阿育吠陀生物学和逆向阿育吠陀治疗学协同作用。这种范式转换愿景可能会带来实用的转化研究/实践，并为中西医结合肿瘤学带来系统障碍和新的桥梁。

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