Journal of Ayurveda and Integrative Medicine最新文献

英文中文

Exploring the anti-inflammatory effects of acupuncture and Chinese herbal medicine targeting the miRNA-146a/IRAK1/JNK1 pathway in an environmental dry eye rat model 在环境性干眼症大鼠模型中探索针对 miRNA-146a/IRAK1/JNK1 通路的针灸和中药的抗炎作用

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2024-11-01 DOI: 10.1016/j.jaim.2024.100998

Lei Zhao , JJ Jiajia Yu , Yulin Liu , Huimin Zhou , Yingyue Cao , Baoqiang Dong , Tao Zuo

Background

Dry eye syndrome has emerged as a subject of substantial significance in the field of ophthalmological research, prompting an exploration of therapeutic approaches.

Objective

This study investigates the anti-inflammatory effects of acupuncture and Chinese herbal medicine in an environmental dry eye (EDE) rat model, focusing on the intricate "miRNA-146a/IRAK1/JNK1" pathway.

Material and methods

The experimental groups included Control, Model, 0.3% Sodium Hyaluronate (SH), Acupuncture (Acup), Herbal medicine (YQCM), and Combined therapy (Acup + YQCM), each aimed at understanding their efficacy in addressing EDE complexities. Treatment efficacy was gauged using various parameters.

Results

Acupuncture and herbal medicine intervention demonstrated significant improvements in tear secretion (SIT) and tear break-up time (BUT). Histological analyses, particularly Hematoxylin and eosin (HE) staining, highlighted improved corneal epithelial cell morphology in the Acup and YQCM groups, effectively mitigating the irregularities observed in the Model group. Notably, Acup + YQCM group exhibited the most promising results (P < 0.05). Scanning electron microscopy showed slightly uneven corneal surfaces in intervention groups, characterized by new epithelial cell growth over the basement membrane and fewer vesicular structures. Acupuncture and herbal medicine intervention yielded significant improvements. On the molecular level, key inflammatory markers including matrix metalloproteinase-9 (MMP-9), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and caspase-3 exhibited significant reductions in response to acupuncture and herbal medicine interventions (P < 0.05). An investigation into the regulatory miRNA-146a/IRAK1/JNK1 pathway unveiled that acupuncture and herbal medicine interventions not only triggered elevated miR-146a expression—an established anti-inflammatory miRNA—but also concurrently downregulated IRAK1 expression, a pivotal inflammation mediator.

Conclusion

This study suggests that the combined application of acupuncture and Chinese herbal medicine may offer a potential anti-inflammatory effect in addressing environment dry eye. The findings indicate promising outcomes, including potential improvements in tear secretion, potential enhancements in corneal morphology, and potential modulation of key inflammatory markers and miRNA pathways. While further research is warranted to validate these findings and elucidate the underlying mechanisms, this study may provide valuable insights into the therapeutic landscape of ocular health. By shedding light on the synergistic effects of acupuncture and herbal medicine, this research underscores the importance of a holistic approach in managing complex ocular conditions.

背景：干眼症已成为眼科研究领域的一个重要课题，促使人们探索治疗方法：本研究探讨了针灸和中药在环境性干眼症（EDE）大鼠模型中的抗炎作用，重点关注复杂的 "miRNA-146a/IRAK1/JNK1 "通路：实验组包括对照组、模型组、0.3% 透明质酸钠组（SH）、针灸组（Acup）、中药组（YQCM）和联合治疗组（Acup + YQCM），旨在了解各组在解决 EDE 复杂问题方面的疗效。治疗效果通过各种参数来衡量：结果：针灸和中药干预显著改善了泪液分泌（SIT）和泪液破裂时间（BUT）。组织学分析，尤其是苏木精和伊红（HE）染色，显示针灸组和 YQCM 组的角膜上皮细胞形态有所改善，有效缓解了模型组观察到的不规则现象。值得注意的是，Acup + YQCM 组显示出最有希望的结果（P 结论：Acup 和 YQCM 联合应用可改善角膜上皮细胞形态：本研究表明，针灸和中草药的联合应用可在解决环境性干眼症方面提供潜在的抗炎效果。研究结果表明，针灸和中草药的联合应用具有良好的效果，包括可能改善泪液分泌、可能改善角膜形态、可能调节关键炎症标志物和 miRNA 通路。虽然还需要进一步的研究来验证这些发现并阐明其潜在机制，但这项研究可能会为眼部健康治疗领域提供有价值的见解。通过阐明针灸和中药的协同作用，这项研究强调了综合方法在治疗复杂眼部疾病中的重要性。

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引用次数: 0

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2024-11-01 DOI: 10.1016/j.jaim.2024.101106

Ravindra Ghooi

引用次数: 0

In silico exploration of phytocompounds from AYUSH-64 medicinal plants against SARS CoV-2 RNA-dependent RNA polymerase 针对 SARS CoV-2 RNA 依赖性 RNA 聚合酶的 AYUSH-64 药用植物植物化合物的硅学探索。

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2024-11-01 DOI: 10.1016/j.jaim.2024.101026

Srinivasulu Cheemanapalli , Ramanjaneyulu Golla , Sudhakar Pagidi , Seshapani Pantangi

Background

The AYUSH 64 formulation helps to treat mild to moderate cases of COVID-19. Although several drugs have been proposed to combat COVID-19, no medication is available for SARS-CoV-2 infection. The RNA-dependent RNA polymerase (RdRp) is the pivotal enzyme of SARS-CoV-2 replication, so it could be considered a better drug target for experimental studies.

Objective

The AYUSH-64 formulation plants exhibited multiple therapeutic properties; thus, the present study aims to screen the phytocompounds of these plants against SARS CoV2 RdRp to identify specific compounds that could potentially affect COVID-19 infection.

Materials and methods

PatchDock and AutoDock tools were used for docking experiments. MD simulations and Density Functional Theory (DFT) calculations of protein-ligand Picroside-I and Remdesivir complexes were carried out in GROMACS v2019.4 and Gaussian 09 software, respectively.

Results

Among the tested, five phytocompounds (Picroside I, Oleanolic acid, Arvenin I, II, and III) from AYUSH-64 medicinal plants showed possible binding with RdRp catalytic residues (Ser759, Asp760, and Asp761). Of these, Picroside I exhibited hydrogen bond interactions with NTP entry channel residues (Arg553 and Arg555). The MM-PBSA free energy, RMSD, Rg, PCA, and RMSF analysis suggested that the Picroside I complex showed stable binding interactions with RdRp in the 50 ns simulation. In addition to this, Picroside I revealed its robust and attractive nature toward the target protein, as confirmed by DFT.

Conclusion

The results of this study have proposed that Picroside I from AYUSH 64 medicinal plant compounds was the selective binder of catalytic and NTP entry channel residues of SARS-CoV2 RdRp thereby; it may considered as a potential inhibitor of SARS-CoV2 RdRp.

背景：AYUSH 64 配方有助于治疗轻度至中度的 COVID-19 病例。虽然已经提出了几种抗 COVID-19 的药物，但还没有治疗 SARS-CoV-2 感染的药物。RNA 依赖性 RNA 聚合酶（RdRp）是 SARS-CoV-2 复制的关键酶，因此可将其视为实验研究中更好的药物靶点：AYUSH-64 配方植物具有多种治疗特性；因此，本研究旨在筛选这些植物中针对 SARS CoV2 RdRp 的植物化合物，以确定可能影响 COVID-19 感染的特定化合物：使用 PatchDock 和 AutoDock 工具进行对接实验。分别在 GROMACS v2019.4 和 Gaussian 09 软件中对蛋白质配体 Picroside-I 和 Remdesivir 复合物进行了 MD 模拟和密度泛函理论（DFT）计算：在测试的植物化合物中，来自AYUSH-64药用植物的五种植物化合物（Picroside I、齐墩果酸、Arvenin I、II和III）显示可能与RdRp催化残基（Ser759、Asp760和Asp761）结合。其中，Picroside I 与 NTP 进入通道残基（Arg553 和 Arg555）有氢键相互作用。MM-PBSA 自由能、RMSD、Rg、PCA 和 RMSF 分析表明，在 50 ns 模拟中，Picroside I 复合物与 RdRp 发生了稳定的结合相互作用。此外，经 DFT 证实，Picroside I 对目标蛋白质具有稳健的吸引力：本研究结果表明，AYUSH 64 种药用植物化合物中的 Picroside I 能选择性地结合 SARS-CoV2 RdRp 的催化和 NTP 进入通道残基，因此可被视为 SARS-CoV2 RdRp 的潜在抑制剂。

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引用次数: 0

Deep learning for Ethiopian indigenous medicinal plant species identification and classification 深度学习用于埃塞俄比亚本土药用植物物种识别和分类。

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2024-11-01 DOI: 10.1016/j.jaim.2024.100987

Mulugeta Adibaru Kiflie , Durga Prasad Sharma , Mesfin Abebe Haile

Background

Medicinal plants are crucial for traditional healers in preparing remedies and also hold significant importance for the modern pharmaceutical industry, facilitating drug discovery processes. Accurate and effective identification and classification of Ethiopian indigenous medicinal plants are vital for their conservation and preservation. However, the existing identification and classification process is time-consuming, and tedious, and demands the expertise of specialists. Botanists traditionally rely on traditional and experience-based methods for identifying various medicinal plant species.

Objective

This research aims to develop an efficient deep learning model through transfer learning for the identification and classification of Ethiopian indigenous medicinal plant species.

Materials and methods

A custom dataset of 1853 leaf images from 35 species was prepared and labeled by botanist experts. Experiments have been done with the use of pretrained deep learning models, specifically VGG16, VGG19, Inception-V3, and Xception.

Results

The results demonstrate that fine-tuning the models significantly improves training and test accuracy, indicating the potential of deep learning in this domain. VGG19 outperforms other models with a test accuracy of 94%, followed by VGG16, Inception-V3, and Xception with test accuracies of 92%, 91%, and 87%, respectively. The study successfully addresses the challenges in the identification and classification of Ethiopian indigenous medicinal plant species.

Conclusion

With an inspiring accuracy performance of 95%, it can be concluded that fine-tuning emerged as a highly effective strategy for boosting the performance of deep learning models.

背景：药用植物对传统医士配制药方至关重要，同时也对现代制药业具有重要意义，有助于药物研发过程。对埃塞俄比亚本土药用植物进行准确有效的鉴定和分类对其保护和保存至关重要。然而，现有的鉴定和分类过程耗时且繁琐，需要专家的专业知识。植物学家传统上依靠传统和基于经验的方法来鉴定各种药用植物物种：本研究旨在通过迁移学习开发一种高效的深度学习模型，用于识别和分类埃塞俄比亚本土药用植物物种：定制数据集包含 35 个物种的 1853 张叶片图像，并由植物学家专家进行标注。实验使用了预先训练好的深度学习模型，特别是 VGG16、VGG19、Inception-V3 和 Xception：结果表明，对模型进行微调可显著提高训练和测试的准确性，这表明深度学习在这一领域的潜力。VGG19 的测试准确率为 94%，优于其他模型，其次是 VGG16、Inception-V3 和 Xception，测试准确率分别为 92%、91% 和 87%。这项研究成功地解决了埃塞俄比亚本土药用植物物种鉴定和分类的难题：通过令人振奋的 95% 的准确率表现，可以得出结论：微调是提高深度学习模型性能的一种非常有效的策略。

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引用次数: 0

Classical ayurveda management of TCH (taxane, carboplatin, and herceptin) based chemotherapy induced peripheral neuropathy- A case report 基于 TCH（紫杉类药物、卡铂和赫赛汀）化疗引起的周围神经病变的经典阿育吠陀疗法--病例报告

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.101044

Zankhana Buch , Suprabha Hegde , Aishwarya Lakshmi , Swathi Bhat

Although empirical data on the influence of Ayurveda on Chemo/Radiotherapy-induced side effects are limited, its methodological framework, grounded in a 'systems thinking' perspective, enables the precise delineation of the pathogenic stage of these side effects. This, in turn, facilitates the development of a strategy to address the decline in the quality of life parameters commonly associated with cancer treatment. Ayurveda personalized approach to disease management typically involves providing customized diets, lifestyle adjustments, medications, and detoxification therapies that target the entire body.

We present a case involving a patient with numbness and pain in the right hand after undergoing chemotherapy who was referred to us by an oncologist for symptom management. This case report demonstrates the Ayurveda approach for establishing the etiology, pathogenesis, pathophysiology, and treatment of Chemotherapy-Induced Peripheral Neuropathy (CIPN) resulting from taxane-based chemotherapy. Following Ayurveda intervention, the patient exhibited significant improvements in symptoms and quality of life parameters.

This case report systematically illustrates the application of Ayurveda approach in CIPN management.

虽然有关阿育吠陀对化疗/放疗引起的副作用的影响的经验数据有限，但其基于 "系统思维 "视角的方法论框架能够精确划分这些副作用的致病阶段。这反过来又有助于制定战略，解决癌症治疗中常见的生活质量下降问题。阿育吠陀个性化的疾病管理方法通常包括提供针对全身的定制饮食、生活方式调整、药物和排毒疗法。我们介绍了一例化疗后右手麻木和疼痛的患者病例，该患者是由肿瘤专家转介到我们这里进行症状管理的。本病例报告展示了阿育吠陀确定化疗引起的周围神经病变（CIPN）的病因、发病机制、病理生理学和治疗方法的方法。本病例报告系统地说明了阿育吠陀疗法在 CIPN 治疗中的应用。

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引用次数: 0

Ayurvedic management of hydatid cyst of lungs: A case report 阿育吠陀疗法治疗肺水瘤囊肿：病例报告

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.101000

Praveen K. Yadav , Pradeep S. Shindhe , Ramesh S. Killedar , Mandeep Singh

Cystic echinococcosis (CE), which is present in all parts of the world, is caused by the bacterium Echinococcus granulosus. One of the most serious parasitic infectious diseases affecting both humans and animals, CE causes hydatid cysts that can lodge in various host organs, including the liver, lungs, heart, and brain, which can be fatal. Treatment options for cystic echinococcosis are active anthelmintics, surgery, and percutaneous aspiration. Numerous scolicidal chemical agents are in practice, but due to increased drug resistance and adverse reactions associated with drugs, usage is limited. Finding alternative therapies with the least or no side effects to manage the condition is the need of the hour. Here, we report a case of an asymptomatic hydatid lung cyst that was managed using Ayurvedic treatment principles. A 57-year-old businessman, asymptomatic, came with a diagnosis of Hydatid lung disease confirmed by CT scan. Surgery was advised, but the patient approached for Ayurveda treatment. The case was treated with oral medicines like Arogyavardhini gutika, Goarka, Kanchanara guggulu, Vidangasava, Kapalabhati pranayama for a period of 8 months. Complete resolution of the cyst was seen, which was evident by a CT scan. Promising results were seen in the present case, but further research in this area is required to produce evidence-based results.

囊性棘球蚴病（CE）存在于世界各地，是由颗粒棘球蚴细菌引起的。囊性棘球蚴病是影响人类和动物的最严重的寄生虫传染病之一，它导致的包虫囊肿可寄生在宿主的各种器官中，包括肝脏、肺部、心脏和大脑，可导致死亡。囊性棘球蚴病的治疗方法有活性驱虫药、手术和经皮抽吸。目前使用的杀虫化学制剂很多，但由于耐药性和药物不良反应的增加，使用受到限制。寻找副作用小或无副作用的替代疗法来控制病情是当务之急。在此，我们报告了一例采用阿育吠陀治疗原则治疗的无症状肺包虫囊肿病例。一名无症状的 57 岁商人经 CT 扫描确诊为肺包虫病。医生建议进行手术治疗，但患者要求接受阿育吠陀治疗。患者接受了为期 8 个月的口服药物治疗，如 Arogyavardhini gutika、Goarka、Kanchanara guggulu、Vidangasava 和 Kapalabhati pranayama。CT 扫描显示，囊肿已完全消退。本病例取得了良好的疗效，但还需要在这一领域开展进一步的研究，以取得循证结果。

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引用次数: 0

A systematic review and meta-analysis focusing on the use of ayurvedic medicine in cerebral palsy 系统性回顾和荟萃分析，重点关注阿育吠陀医学在脑瘫中的应用。

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.101035

A.M.O. Rocha , C.A. Len , F.H. Santos , S.B.O. Iglesias , J.R. Bissoto

Integrative practices have been incorporated into palliative care to provide holistic and multidimensional care for patients.

This study aims to identify the scope of integrative practices, specifically whole medical systems, and demonstrate its safety and efficacy, specially in children with cerebral palsy.

Key databases, including Embase, Cochrane, Medline/PubMed, Scopus, Google Scholar, Lilacs and Scielo were searched using specific terms.

Only randomized and non-randomized clinical trials were included for meta-analysis purposes. Case-control, cohort, cross-sectional or retrospective observational studies were also included for the systematic review. Participants included children aged 0–18 years receiving palliative care for cerebral palsy and undergoing Ayurvedic Medicine practices.

Descriptive analysis was conducted, including data such as year; author; design; sample size; intervention and comparison; outcomes and conclusion.

Two interventional studies compared Ayurvedic practices with each other or with physiotherapy in children with cerebral palsy. The meta-analysis demonstrated an improvement in spasticity for children using Ayurvedic medicine. However, there were limitations in terms of heterogeneity in interventions, control groups, and assessed outcomes.

Integrative practices, including Ayurvedic medicine have the potential to improve quality of life, manage disease symptoms and provide emotional support. However, more robust evidence is needed to support their widespread use. The use of Ayurvedic medicine showed evidence of improvement in spasticity for children with cerebral palsy.

Registration number

Prospero CRD 42020198399.

中西医结合疗法已被纳入姑息治疗，为患者提供全方位、多角度的护理。本研究旨在确定综合疗法的范围，特别是整体医疗系统，并证明其安全性和有效性，尤其是对脑瘫儿童的安全性和有效性。本研究使用特定术语搜索了主要数据库，包括 Embase、Cochrane、Medline/PubMed、Scopus、Google Scholar、Lilacs 和 Scielo。荟萃分析仅纳入随机和非随机临床试验。系统综述还包括病例对照、队列、横断面或回顾性观察研究。参与者包括接受脑瘫姑息治疗和阿育吠陀医学实践的 0-18 岁儿童。研究进行了描述性分析，包括年份、作者、设计、样本大小、干预和比较、结果和结论等数据。两项干预性研究比较了阿育吠陀疗法与其他疗法或物理疗法对脑瘫儿童的治疗效果。荟萃分析表明，使用阿育吠陀疗法的儿童痉挛情况有所改善。但是，在干预措施、对照组和评估结果的异质性方面存在局限性。包括阿育吠陀医学在内的综合疗法有可能改善生活质量、控制疾病症状并提供情感支持。然而，还需要更有力的证据来支持其广泛应用。使用阿育吠陀医学有证据表明可以改善脑瘫儿童的痉挛状况。注册编号：Prospero CRD 42020198399。

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引用次数: 0

Integrating Ayurveda and modern mainstream medicine 阿育吠陀与现代主流医学相结合。

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.100997

K.P. Mohanan

This article is an attempt to understand the challenge of integrating the education provided by BAMS programs and MBBS programs, in order to initiate the process of integrating research and practice in Ayurveda and Modern Mainstream Medicine. The specific issues discussed in the article are framed within the broader context of the challenge of integrating any two bodies of knowledge, theories, or knowledge systems in education and research.

这篇文章试图了解将印度医学和印度医学科学院（BAMS）提供的教育与印度医学和印度医学科学院（MBBS）提供的教育相结合所面临的挑战，从而启动阿育吠陀与现代主流医学研究与实践相结合的进程。文章中讨论的具体问题是在将任何两种知识体系、理论或知识体系整合到教育和研究中这一更广泛的背景下提出的。

引用次数: 0

Ayurinformatics Laboratory- A synergy platform for Ayurveda and technology Ayurinformatics 实验室--阿育吠陀与技术的协同平台。

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.101019

Prashant Kumar Gupta , Tanuja Manoj Nesari

The Ayush sector has attained buoyant growth in the past decade as a science, public health, medicine, and industry. Artificial Intelligence, computational drug designing, and other combinatorial techniques could further accelerate the sector's growth. In this edition, we delve into the confluence of Ayurveda and technology, a theme that resonates profoundly in the contemporary healthcare and wellness landscape. The fusion of Ayurveda, an ancient system of medicine rooted in holistic well-being, with cutting-edge technology, is not just a paradigm shift but a necessary evolution in pursuing an integrated healthcare system where all systems have their defined, recognized, and respected contribution. Here, We are highlight one-such fusion initiative "Ayurinformatics Laboratory".

作为一门科学、公共卫生、医学和工业，阿育什学在过去十年中取得了蓬勃发展。人工智能、计算药物设计和其他组合技术将进一步加速该行业的发展。在本版中，我们将深入探讨阿育吠陀与技术的融合，这一主题在当代医疗保健和健康领域引起了深刻共鸣。阿育吠陀是一种植根于整体健康的古老医学体系，它与尖端技术的融合不仅是一种模式的转变，也是追求综合医疗体系的必要发展，在这种体系中，所有系统都有其明确、公认和受尊重的贡献。在此，我们重点介绍 "阿育信息学实验室 "这一融合举措。

引用次数: 0

Introduction of journal clubs for UG students of Ayurveda, a dire necessity 为阿育吠陀学本科生开设期刊俱乐部是当务之急

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.100977

Gaurav Soni

引用次数: 0

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