Journal of Ayurveda and Integrative Medicine最新文献

{"title":"The impact of meditation on sustained attention in nonclinical population: An extensive review","authors":"Abinash Roy,&nbsp;Pailoor Subramanya","doi":"10.1016/j.jaim.2024.101057","DOIUrl":"10.1016/j.jaim.2024.101057","url":null,"abstract":"<div><h3>Background</h3><div>Meditation, encompassing focussed attention (FA) and open monitoring (OM) approaches, is recognised for its potential to enhance cognitive functions. Sustained attention, a critical component of attentional processes, influences cognitive capacity and is linked to meditation benefits. However, a robust and extensive review analysis needs to address the specific relationship between meditation and sustained attention in nonclinical populations.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, the authors reviewed English articles published from 2013 to 2023 in Q1 SCOPUS-indexed journals. Inclusion criteria comprised original research studies exploring the impact of meditation on sustained attention in healthy individuals. The modified Jadad Scale assessed methodological quality.</div></div><div><h3>Results</h3><div>12 studies (four RCTs, eight non-RCTs) with 1447 participants were included. Concentrative or FA meditation demonstrated consistent positive effects on sustained attention, including reduced perceived stress and increased focussed attention. OM meditation significantly improved sustained attention, as evidenced by reduced mind wandering and enhanced N2 responses. Meditators consistently outperformed non-meditators in sustained attention tasks, demonstrating faster reactions and lower error rates.</div></div><div><h3>Discussion</h3><div>This review explored the impact of meditation on sustained attention across diverse non-clinical populations through 12 investigations involving 1447 subjects with meditation interventions spanning from 21 days to 3 months. The study revealed that both FA and OM meditation approaches positively impact sustained attention, highlighting their potential role in enhancing cognitive function. Meditators consistently exhibited superior sustained attention abilities, suggesting the cognitive benefits of regular meditation practice. The findings of this study are consistent with prior research, contributing to the growing body of knowledge on the advantageous impacts of meditation on sustained attention. However, caution is needed in generalizing findings due to study limitations. Future research should use standardized methodologies and conduct longer-term follow-ups to better elucidate the effects of meditation interventions on sustained attention across diverse populations.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101057"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective, randomized, open label, parallel group, comparative clinical trial to evaluate the safety and efficacy of combination of herbal oral capsule and rectal medication to improve gut health of type 2 diabetic patients having chronic kidney disease (CKD)","authors":"Suresh Patankar ,&nbsp;Anupama Gorde ,&nbsp;Sagar Patankar ,&nbsp;Rajesh Raje ,&nbsp;Chandu Devanpally ,&nbsp;Pranjal Ausekar ,&nbsp;Gaurav Patil ,&nbsp;Shraddha Chitale","doi":"10.1016/j.jaim.2024.100992","DOIUrl":"10.1016/j.jaim.2024.100992","url":null,"abstract":"<div><h3>Background</h3><div>Chronic kidney disease (CKD) is a major health concern globally, with more than 850 million people suffering from it. Several studies have been carried out to reduce inflammation in CKD patients; and to study the relationship between gut microbiota and inflammation.</div></div><div><h3>Objective</h3><div>The effect of herbal formulations to improve the gut flora and reduce inflammation has not been studied earlier. The study aims to evaluate effect of herbal formulation combined with standard of care (SOC) treatment compared to SOC.</div></div><div><h3>Methods</h3><div>A prospective, randomized, parallel group clinical trial was planned on 90 patients split equally into standard of care (SOC) with herbal treatment (IP) and only SOC groups. The change in the abdominal pain score, percent change in the pathogenic and non-pathogenic microbiome were the key endpoints of interest. The safety assessment was in terms of adverse events, changes in hematological and biochemical parameters.</div></div><div><h3>Results</h3><div>The demographic and other patient characteristics showed statistically non-significant differences between two groups. On day 90, the median abdominal score in SOC + IP group (2.00) was significantly lower than that of SOC group (3.00) (p = 0.002). The quality of life score improved significantly in SOC + IP group (p &lt; 0.001), unlike SOC group. There was significant reduction in pathogenic microbes in SOC + IP group; however, the reduction in non-pathogenic microbes was non-significant in this group. The adverse events (AEs) were in mild form, and the proportion of patients with AEs differed non-significantly between two groups.</div></div><div><h3>Conclusion</h3><div>The IP supplementation along with SOC significantly improved the GUT micro flora, and improved the overall quality of life of CKD patients. This treatment combination can be practiced for effective patient management.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 100992"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Ayurvedic treatment given to cancer patients in the prevention of COVID-19 – A Retrospective Cohort Study at Integrated Cancer Treatment and Research Centre, Wagholi","authors":"Sadanand Sardeshmukh,&nbsp;Vineeta Deshmukh,&nbsp;Vidya Gupta,&nbsp;Vasanti Godse,&nbsp;Shweta Gujar,&nbsp;Swapna Kulkarni,&nbsp;Sneha Dalvi,&nbsp;Nilambari Sardeshmukh,&nbsp;Bhagyashree Sardeshmukh,&nbsp;Sushama Bhuvad,&nbsp;Sandeep Chavan,&nbsp;Vinita Awalkanthe,&nbsp;Shrinivas Datar,&nbsp;Anita Shingte,&nbsp;Abhishek Salunkhe,&nbsp;Amruta Salunkhe,&nbsp;Sneha Nabar,&nbsp;Dhananjay Deshpande,&nbsp;Trupti Dafare","doi":"10.1016/j.jaim.2024.101045","DOIUrl":"10.1016/j.jaim.2024.101045","url":null,"abstract":"<div><h3>Background</h3><div>Cancer patients are considered to have a higher risk of developing severe Coronavirus Disease 2019 (COVID-19) and a higher mortality rate. Moreover, poor prognosis observed in them is associated with multiple co-morbidities. Ayurveda can prove to be effective in preventing COVID-19 as well as improving clinical outcomes against COVID-19 in cancer patients.</div></div><div><h3>Objectives</h3><div>To evaluate the effect of Ayurvedic treatments given to cancer patients as also a preventive modality against COVID-19 infections.</div></div><div><h3>Methods</h3><div>700 cancer patients were enrolled in the study. The demographic information regarding their age, sex, organs involved, stage, pre-existing comorbidities, Karnofsky score, addictions, undergoing conventional cancer treatment, type of conventional treatment, and duration of Ayurvedic cancer treatment was collected from the institutional records. These patients were interviewed telephonically or in person to obtain information related to their COVID-19 status from March 2020 to Sep 2021, which included a) whether they were affected with COVID-19 or not, b) If affected, the severity of COVID-19 symptoms, c) vaccination status, d) mortality, and e) if in contact with relative affected by COVID-19.</div></div><div><h3>Results</h3><div>The surveyed cohort had 56 years as the median age, more female patients, Karnofsky score between 80 and 100, and hypertension as well as diabetes as major co-morbidities. During the 1st and 2nd waves, 34 (4.85%) and 65 patients (10.09 %) were COVID-19 positive while 4.91 % and 11.11% of patients with addictions were covid positive, respectively, the rest remained unaffected.</div><div>There was no specific trend in % of COVID-19-positive cancer patients concerning stage, but those with stage IV undergoing conventional treatment showed increased prevalence (p &lt; 0.001). Prolonged Ayurvedic treatment exhibited a decreasing trend in % COVID-19 positive patients, which is highly significant (p &lt; 0.001). Specifically, those undergoing conventional therapy, and also received Ayurvedic treatment simultaneously for more than 3 years remained unaffected by COVID-19, which was statistically significant in both waves (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Ayurvedic treatments given to cancer patients are effective in preventing COVID-19 infections in these patients.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101045"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AyurCeL: A comprehensive ayurveda clinical E-learning platform","authors":"Rammanohar Puthiyedath ,&nbsp;Sushma Naranappa Salethoor ,&nbsp;Shyamasundaran Kulangara ,&nbsp;Raghu Raman ,&nbsp;Nagarajan Chockan ,&nbsp;Anupama Kizhakkeveettil ,&nbsp;Prema Nedungadi","doi":"10.1016/j.jaim.2024.101107","DOIUrl":"10.1016/j.jaim.2024.101107","url":null,"abstract":"<div><div>Ayurveda, an ancient holistic medicinal system, has sustained its relevance over millennia and continues to be practised extensively in India. However, challenges persist in clinical expertise among Ayurvedic practitioners, often due to limited clinical exposure during their academic journey. The Ayurveda Clinical E-Learning Portal (AyurCeL) aims to bridge the gap in clinical expertise among Ayurvedic practitioners by providing a digital platform for sharing well-documented clinical case studies. This paper outlines the objectives, architecture, and comprehensive modules of AyurCeL, emphasizing its role in facilitating continuous clinical learning and improving the quality of Ayurvedic practice. AyurCeL offers a multi-faceted approach to learning, featuring a clinical case repository, Ayurveda case report preprint archive and post-publication review tool. By merging traditional insights with contemporary technology, AyurCeL not only preserves Ayurveda's profound legacy but also enhances its relevance and reach in today's medical landscape.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101107"},"PeriodicalIF":1.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In pursuit of evidence: A need to transform Ayurvedic education","authors":"Sruthi G,&nbsp;Megha","doi":"10.1016/j.jaim.2024.101110","DOIUrl":"10.1016/j.jaim.2024.101110","url":null,"abstract":"<div><div>There is a loud call nationally and internationally to strengthen the evidence base for traditional medicine. Ayurveda, like other traditional systems, is often criticized for its lack of evidence upto the standard expected for modern day healthcare drugs and practices. This gap in evidence has led to Ayurveda being viewed as inferior to biomedicine. Therefore, producing high-quality evidence is essential not only for the credibility of Ayurveda but also to elevate its inclusion in standard of care practices globally. Yet, how can this evidence be generated if Ayurvedic researchers and practitioners are not formally taught about the advantages and means of evidence synthesis? The prevailing research culture in Ayurveda largely emphasizes validating ayurvedic formulations by substituting them into well-established clinical protocols for modern disease descriptors, rather than focusing on hypothesis-driven research using ayurvedic vocabulary. We argue that this arises in part from an outdated curriculum, poorly trained teachers, insufficient investment in research infrastructure at teaching colleges, and a paucity of policies to encourage cross-disciplinary learning. To address these gaps, we propose a comprehensive transformation of Ayurvedic education by including biomedical credit courses into the curriculum, practical internships to provide hands-on-experience, recruitment of teachers with biomedical expertise and funds to upgrade Ayurveda colleges. These ideas will help develop a cohort of Ayurveda graduates who are not only familiar with modern biomedicine, but also have the fundamental knowledge to develop, and test new ideas. India can emerge as a global leader in the area of integrative medicine, with its repository of several indigenous medical systems, and talented human capital in biomedical sciences. It is time we take the plunge.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101110"},"PeriodicalIF":1.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research status of traditional & complementary medicine systems across the world","authors":"Vedvati Bhapkar ,&nbsp;Vallari Nisargand ,&nbsp;Pawankumar Godatwar ,&nbsp;Supriya Bhalerao","doi":"10.1016/j.jaim.2024.101078","DOIUrl":"10.1016/j.jaim.2024.101078","url":null,"abstract":"<div><h3>Background</h3><div>Despite strong presence of biomedicine, traditional and complementary medicine (T &amp; CM) systems have sustained with their multidimensional connect with people. However, their scientific acceptance and mainstreaming falls short due to inadequacies in research. Also, available reports in this regard scarcely focus on their individuality and present them as a consolidated entity.</div></div><div><h3>Objectives</h3><div>The present study was carried out to elucidate individual research status of certain WHO- acknowledged T &amp; CM systems in a customized framework of indirect indicators.</div></div><div><h3>Material and methods</h3><div>The research status of selected systems was assessed on basis of quantitative indicators viz., research dissemination outcomes concerned with scientific documents and researchers, contribution in COVID-19 prevention and management, and patents profile.</div></div><div><h3>Results</h3><div>Systems such as Traditional Chinese Medicine and Acupuncture fare better than most others. The number of documents in multidisciplinary SCOPUS database was larger than those in PubMed, a healthcare database for almost all systems. Out of 28 lead authors, half belonged to developed countries, viz., USA and Germany. Highest citation count was recorded for TCM (n = 2238). Of the 105 journals analyzed, 40 were not dedicated to specific T &amp; CM system. Most number of discretely dedicated journals (n = 20) mentioned TCM as primary scope. Cochrane systematic reviews (n = 142) and protocols (n = 33) were highest for Acupuncture, while many systems had zero presence. Maximum COVID-19 related clinical studies were registered for TCM (n = 335), followed by Ayurveda (n = 112). TCM related patents were also highest among all.</div></div><div><h3>Conclusion</h3><div>There is a huge variation in the research status of different T &amp; CM systems. The stakeholders of these systems need to establish a strong evidence base at par with biomedicine. United efforts at global level through organizations such as WHO-Global Traditional Medicine Centre (GTMC) might be helpful in this regard.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101078"},"PeriodicalIF":1.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the radioprotector chlorophyllin on graft versus leukemia response in experimental allogeneic hematopoietic stem cell transplantation","authors":"Saurabh Kumar Gupta ,&nbsp;Subhash Yadav ,&nbsp;Deepak Sharma ,&nbsp;Santosh Kumar Sandur ,&nbsp;Navin Khattry ,&nbsp;Jayant Sastri Goda ,&nbsp;Vikram Gota","doi":"10.1016/j.jaim.2024.101109","DOIUrl":"10.1016/j.jaim.2024.101109","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101109"},"PeriodicalIF":1.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143260022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological effects of herbal ingredients of Manasamitra vatakam in the treatment of Alzheimer's disease: A review","authors":"Anju C. Nair ,&nbsp;Beena Briget Kuriakose ,&nbsp;Aswini Biju ,&nbsp;Sarika Surendran ,&nbsp;M.S. Sudheesh ,&nbsp;P.K. Lakshmi","doi":"10.1016/j.jaim.2024.101041","DOIUrl":"10.1016/j.jaim.2024.101041","url":null,"abstract":"<div><div>Multi-targeted drug therapy has received substantial attention for the treatment of diseases of multi-factorial origin, including neurodegenerative and autoimmune diseases. It seems reasonable to argue that the complex pathology of neurodegenerative diseases (ND) cannot be reduced to a single target to modulate a broad range of cellular signaling, associated pathologies, and symptoms. It is this idea that has brought the attention of the scientific world towards phytochemicals and traditional drugs that are notoriously multi-targeted. A systematic study of these formulations and establishing the molecular pathways of individual molecules can lead to a standardized multi-component product that can modulate a broad range of activities on different targets of ND. This could provide an accessible and affordable solution to the significant disease burden of ND. With this idea in mind, a systematic review was carried out on an Ayurvedic product <em>Manasamitra Vatakam (</em>MMV), known to be a neuroprotective formulation and highly effective against Alzheimer's disease. MMV can be a source of phytomolecules for treating neurodegenerative diseases. The multifactorial nature of these diseases makes them suitable candidates for testing phytochemicals due to the inherent multitargeting capabilities of these compounds. The primary objective of this review is to provide a comprehensive understanding of the phytomolecules from MMV that are responsible for its multitargeted effect against neurodegenerative diseases. From the reported literature, it is clear that many phytoconstituents and extracts of the herbal ingredients from MMV have demonstrated their efficacy against AD models. However, the combination of these molecules in AD models has never been tested. Scientific studies should be done to explore the bioactive compounds in the formulation and the druggability of these identified compounds can be evaluated using experimental methods.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"Article 101041"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potency of ethyl acetate fraction of cempedak (Artocarpus champeden) leaves in attenuating the nephrotoxic effect in gentamicin-piroxicam-induced rat models","authors":"Fitrya ,&nbsp;Elfita ,&nbsp;Syafrina Lamin ,&nbsp;Fima Amalia Ashfa ,&nbsp;Rennie Puspa Novita ,&nbsp;Annisa Amriani","doi":"10.1016/j.jaim.2024.101040","DOIUrl":"10.1016/j.jaim.2024.101040","url":null,"abstract":"<div><h3>Background</h3><div>Nephrotoxicity is a condition characterized by a decline in kidney function due to the toxic effects of medications and substances, such as the nephrotoxic antibiotic gentamicin. <em>Artocarpus champeden</em> is a traditional medicinal plant that is commonly found in Indonesia.</div></div><div><h3>Objective</h3><div>This study aims to evaluate the potential of the ethyl acetate fraction of <em>Artocarpus champeden</em> leaves (FEC) in improving kidney function in an animal model of nephrotoxicity induced by gentamicin and piroxicam.</div></div><div><h3>Materials and Methods</h3><div>Three groups of animals were treated with FEC at dosages of 125, 250, and 500 mg/kg BW orally for four weeks following induction with 100 mg/kg gentamicin (Gen) intraperitoneally and 3.6 mg/kg piroxicam (Prx) orally. The nephroprotective effect of FEC was compared with the NaCMC (5%), ketosteril (55 mg/kg), and untreated groups as the normal, positive, and negative controls, respectively. The kidney biochemical examinations and histopathological analysis were conducted on the last day.</div></div><div><h3>Results</h3><div>Compared to the negative control group, FEC-treated animals showed significant improvement in kidney function, correlating with increasing doses. The test group also exhibited increased creatinine clearance and improved cell structure, comparable to samples treated with ketosteril. The nephroprotective effect of FEC is likely attributed to its flavonoid content, acting through antioxidant and anti-inflammatory mechanisms.</div></div><div><h3>Conclusion</h3><div>The ethyl acetate fraction of <em>A. champeden</em> leaves demonstrated nephroprotective activity and has potential as a therapeutic agent for kidney damage and hypertension from natural sources.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"Article 101040"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terminalia catappa aqueous extract reduces hyperglycaemia and oxidative stress in diabetic-hypercholesterolemic rats","authors":"Ojaskumar D. Agrawal ,&nbsp;Yogesh A. Kulkarni","doi":"10.1016/j.jaim.2024.101025","DOIUrl":"10.1016/j.jaim.2024.101025","url":null,"abstract":"<div><h3>Background</h3><div><em>Terminalia catappa</em> is an important medicinal plant. Plants from the genus <em>Terminalia</em> have been reported for antidiabetic effects.</div></div><div><h3>Objective</h3><div>To study effect of <em>Terminalia catappa</em> leaves aqueous extract in type 2 diabetic rats.</div></div><div><h3>Materials and methods</h3><div>High-fat diet (HFD) and a low dose of streptozotocin (35 mg/kg, <em>i.p.</em>) were used for inducing type 2 diabetes in rats; streptozotocin was injected after two weeks of dietary modification with HFD. HFD was continued throughout the study. Doses of 500 and 1000 mg/kg of aqueous extract of <em>Terminalia catappa</em> were used as a treatment for six weeks. At the end of the study, biochemical and oxidative stress parameters were estimated. Histopathology and immunohistochemistry of pancreatic tissue were performed.</div></div><div><h3>Results</h3><div>Significant decrease (<em>p</em> &lt; 0.01, p &lt; 0.001) was observed in glucose levels of diabetic animals treated with <em>T. catappa</em> extract at both dose levels when compared with diabetic control group. Treatment with aqueous extract reduced cholesterol levels significantly (<em>p</em> &lt; 0.05). After receiving 1000 mg/kg of extract, the triglyceride level was significantly lowered (<em>p</em> &lt; 0.01) in the diabetic rats. Extract treatment enhanced the insulin sensitivity index (ISI), while insulin levels and HOMA-IR were markedly reduced. Treatment with 1000 mg/kg of extract significantly enhanced the levels of GSH and catalase. Histopathological analysis of the pancreas showed that damage caused by hyperglycemia was prevented in the extract-treated groups. Pancreatic tissue showed an increased expression of SIRT1 in extract-treated animals.</div></div><div><h3>Conclusion</h3><div>The current study's findings prove that the extract has remarkable antidiabetic effects.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"Article 101025"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}