A Mendelian randomization study: physical activities and chronic kidney disease.

IF 3 3区 医学 Q1 UROLOGY & NEPHROLOGY Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-01-04 DOI:10.1080/0886022X.2023.2295011
Rui Xiao, Li Dong, Bo Xie, Beizhong Liu
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Abstract

Increasing evidence has shown that physical activity is related to a lower risk of chronic kidney disease (CKD), thus indicating a potential target for prevention. However, the causality is not clear; specifically, physical activity may protect against CKD, and CKD may lead to a reduction in physical activity. Our study examined the potential bidirectional relationship between physical activity and CKD by using a genetically informed method. Genome-wide association studies from the UK Biobank baseline data were used for physical activity phenotypes and included 460,376 participants. For kidney function (estimated Glomerular Filtration Rate (eGFR) and CKD, with eGFR < 60 mL/min/1.73 m2), CKDGen Consortium data were used, which included 480,698 CKD participants of European ancestry. Mendelian randomization (MR) analysis was used to determine the causal relationship between physical activities and kidney function. Two-sample MR genetically predicted that heavy DIY (do it yourself) (e.g., weeding, lawn mowing, carpentry, and digging) decreased the risk of CKD (odds ratio [OR] = 0.287, 95% CI = 0.117-0.705, p = 0.0065) and improved the level of eGFR (β = 0.036, 95% CI = 0.005-0.067, p = 0.021). The bidirectional MR showed no reverse causality. It is worth noting that other physical activities, such as walking for pleasure, strenuous sports, light DIY (e.g., pruning and watering the lawn), and other exercises (e.g., swimming, cycling, keeping fit, and bowling), were not significantly correlated with CKD and eGFR. This study used genetic data to provide reliable and robust causal evidence that heavy physical activity (e.g., weeding, lawn mowing, carpentry, and digging) can protect kidney function and further lower the risk of CKD.

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孟德尔随机研究:体育活动与慢性肾病。
越来越多的证据表明,体育锻炼与降低慢性肾脏病(CKD)的风险有关,从而表明这是一个潜在的预防目标。然而,其中的因果关系并不清楚;具体来说,体育锻炼可能会预防慢性肾脏病,而慢性肾脏病可能会导致体育锻炼减少。我们的研究采用基因信息方法研究了体育锻炼与慢性肾脏病之间的潜在双向关系。英国生物库基线数据中的全基因组关联研究用于研究体育锻炼表型,共纳入 460,376 名参与者。肾功能(估计肾小球滤过率(eGFR)和 CKD,eGFR < 60 mL/min/1.73 m2)方面,使用了 CKDGen Consortium 的数据,其中包括 480,698 名欧洲血统的 CKD 参与者。孟德尔随机化(MR)分析用于确定体育活动与肾功能之间的因果关系。双样本 MR 从遗传学角度预测,繁重的 DIY(自己动手)(如除草、割草、木工和挖掘)会降低患 CKD 的风险(几率比 [OR] = 0.287,95% CI = 0.117-0.705,p = 0.0065),并改善 eGFR 水平(β = 0.036,95% CI = 0.005-0.067,p = 0.021)。双向 MR 显示没有反向因果关系。值得注意的是,其他体力活动,如散步消遣、剧烈运动、轻度 DIY(如修剪和浇灌草坪)以及其他运动(如游泳、骑自行车、健身和保龄球)与 CKD 和 eGFR 没有显著相关性。这项研究利用基因数据提供了可靠而有力的因果关系证据,证明重体力活动(如除草、修剪草坪、木工和挖掘)可以保护肾功能,进一步降低患慢性肾功能衰竭的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Renal Failure
Renal Failure 医学-泌尿学与肾脏学
CiteScore
3.90
自引率
13.30%
发文量
374
审稿时长
1 months
期刊介绍: Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.
期刊最新文献
The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients. Identification of common and specific fibrosis-related genes in three common chronic kidney diseases. A Mendelian randomization study: physical activities and chronic kidney disease. Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study. Association of frequent intradialytic hypotension with the clinical outcomes of patients on hemodialysis: a prospective cohort study.
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