A Retrospective Clinical Study on Cardiovascular Complications from Colorectal Cancer.

IF 0.7 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Heart Surgery Forum Pub Date : 2023-12-26 DOI:10.59958/hsf.6733

Ting Yin, Jianqi Yang, Xiaojing Liu, Jiaqi Huang, Erxun Dai

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Abstract

Objective: To investigate the incidence and risk factors of cardiovascular complications amongst patients with colorectal cancer (CRC).

Methods: A retrospective cohort study was conducted on 2085 patients diagnosed with CRC in two tertiary hospitals in China between 2015 and 2020. The patients' medical records were reviewed to identify cardiovascular complications, including myocardial infarction, heart failure, stroke, hypertension, coronary heart disease, heart failure, and arrhythmia. The incidence rate of cardiovascular complications was calculated, and Cox proportional hazards regression analysis was used to identify risk factors.

Results: Of the 2085 CRC patients, 329 (15.8%) experienced cardiovascular complications during the follow-up period, with an incidence rate of 17.4 cases per 1000 person-years. The risk was significantly higher in patients who were older than 60 years (adjusted hazard ratio [HR] 2.04, 95% confidence interval [CI] 1.22-3.41), had a higher level of low-density lipoprotein cholesterol (LDL-C) (adjusted HR 2.32, 95% CI 1.31-4.10), had higher levels of serum C-reactive protein (CRP) (adjusted HR 1.57, 95% CI 1.21-2.04), or who underwent chemotherapy or radiotherapy. CRC patients with cardiovascular complications had significantly higher levels of oxidative stress markers, including malondialdehyde (MDA) (5.8 ± 1.2 μmol/L vs. 3.4 ± 0.9 μmol/L, p < 0.001), lower levels of superoxide dismutase (SOD) (85.2 ± 15.6 U/mg protein vs. 112.5 ± 21.3 U/mg protein, p < 0.001), and lower levels of glutathione peroxidase (GPx) (15.6 ± 3.2 U/mg protein vs. 20.4 ± 4.1 U/mg protein, p < 0.001) compared to those without complications. A progressive increase was observed in the proportion of CRC patients with cardiovascular complications over time, rising from 10% in the first year to 38% by the tenth year of follow-up.

Conclusion: Cardiovascular complications pose a high risk in CRC patients, particularly amongst older patients and those with higher levels of LDL-C or CRP. Regular monitoring of cardiovascular function should be considered in the management of patients with CRC.

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大肠癌心血管并发症回顾性临床研究

目的：调查结直肠癌（CRC）患者心血管并发症的发生率和风险因素：调查结直肠癌（CRC）患者心血管并发症的发生率和风险因素：方法：对2015年至2020年间在中国两家三甲医院确诊的2085名CRC患者进行回顾性队列研究。研究人员查阅了患者的病历，以确定心血管并发症，包括心肌梗死、心力衰竭、中风、高血压、冠心病、心力衰竭和心律失常。计算了心血管并发症的发病率，并采用 Cox 比例危险回归分析来确定风险因素：结果：在 2085 名 CRC 患者中，有 329 人（15.8%）在随访期间出现心血管并发症，发病率为 17.4 例/1000 人-年。年龄超过60岁（调整后危险比[HR]2.04，95%置信区间[CI]1.22-3.41）、低密度脂蛋白胆固醇（LDL-C）水平较高（调整后危险比2.32，95%置信区间1.31-4.10）、血清C反应蛋白（CRP）水平较高（调整后危险比1.57，95%置信区间1.21-2.04）或接受过化疗或放疗的患者的风险明显更高。有心血管并发症的 CRC 患者的氧化应激标记物水平明显较高，包括丙二醛（MDA）（5.8 ± 1.2 μmol/L vs. 3.4 ± 0.9 μmol/L，P < 0.001）、超氧化物歧化酶（SOD）水平较低（85.与无并发症者相比，超氧化物歧化酶（SOD）水平较低（85.2 ± 15.6 U/mg 蛋白质 vs 112.5 ± 21.3 U/mg 蛋白质，p < 0.001），谷胱甘肽过氧化物酶（GPx）水平较低（15.6 ± 3.2 U/mg 蛋白质 vs 20.4 ± 4.1 U/mg 蛋白质，p < 0.001）。随着时间的推移，观察到患有心血管并发症的 CRC 患者比例逐渐增加，从第一年的 10% 增加到随访第十年的 38%：结论：心血管并发症是 CRC 患者的高危因素，尤其是老年患者和低密度脂蛋白胆固醇（LDL-C）或 CRP 水平较高的患者。在对 CRC 患者进行管理时，应考虑定期监测心血管功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heart Surgery Forum 医学-外科

CiteScore

1.20

自引率

16.70%

发文量

130

审稿时长

6-12 weeks

期刊介绍： The Heart Surgery Forum® is an international peer-reviewed, open access journal seeking original investigative and clinical work on any subject germane to the science or practice of modern cardiac care. The HSF publishes original scientific reports, collective reviews, case reports, editorials, and letters to the editor. New manuscripts are reviewed by reviewers for originality, content, relevancy and adherence to scientific principles in a double-blind process. The HSF features a streamlined submission and peer review process with an anticipated completion time of 30 to 60 days from the date of receipt of the original manuscript. Authors are encouraged to submit full color images and video that will be included in the web version of the journal at no charge.