Orchestrating axonal organization

IF 28.7 1区医学 Q1 NEUROSCIENCES Nature Reviews Neuroscience Pub Date : 2024-01-05 DOI:10.1038/s41583-023-00789-4

Lisa Heinke

引用次数: 0

Abstract

Cytoplasmic mislocalization of TDP-43 in neurodegenerative disease affects mRNA maturation and protein levels of stathmin-2, leading to a reduction in axon diameter and tearing of outer myelin layers and thereby disrupting neuronal function.

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协调轴突组织

神经退行性疾病中 TDP-43 的胞质误定位会影响 stathmin-2 的 mRNA 成熟和蛋白水平，导致轴突直径减小和外层髓鞘撕裂，从而破坏神经元功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nature Reviews Neuroscience NEUROSCIENCES-

自引率

0.60%

发文量

104

期刊介绍： Nature Reviews Neuroscience is a multidisciplinary journal that covers various fields within neuroscience, aiming to offer a comprehensive understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience, facilitated by powerful experimental techniques and theoretical approaches, have made enduring neurobiological questions more accessible. Nature Reviews Neuroscience serves as a reliable and accessible resource, addressing the breadth and depth of modern neuroscience. It acts as an authoritative and engaging reference for scientists interested in all aspects of neuroscience.

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