Sustainable production of natural products using synthetic biology: Ginsenosides

IF 6.8 2区医学 Q1 CHEMISTRY, MEDICINAL Journal of Ginseng Research Pub Date : 2024-01-03 DOI:10.1016/j.jgr.2023.12.006

So-Hee Son , Jin Kang , YuJin Shin , ChaeYoung Lee , Bong Hyun Sung , Ju Young Lee , Wonsik Lee

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Abstract

Synthetic biology approaches offer potential for large-scale and sustainable production of natural products with bioactive potency, including ginsenosides, providing a means to produce novel compounds with enhanced therapeutic properties. Ginseng, known for its non-toxic and potent qualities in traditional medicine, has been used for various medical needs. Ginseng has shown promise for its antioxidant and neuroprotective properties, and it has been used as a potential agent to boost immunity against various infections when used together with other drugs and vaccines. Given the increasing demand for ginsenosides and the challenges associated with traditional extraction methods, synthetic biology holds promise in the development of therapeutics. In this review, we discuss recent developments in microorganism producer engineering and ginsenoside production in microorganisms using synthetic biology approaches.

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利用合成生物学实现天然产品的可持续生产：人参皂甙

合成生物学方法为大规模、可持续地生产具有生物活性的天然产品（包括人参皂甙）提供了潜力，为生产具有更强治疗特性的新型化合物提供了途径。在传统医学中，人参以其无毒、药效强而著称，一直被用于满足各种医疗需求。人参具有抗氧化和保护神经的功效，与其他药物和疫苗一起使用时，还可作为一种潜在的药剂，增强对各种感染的免疫力。鉴于对人参皂苷的需求日益增长，以及传统提取方法所面临的挑战，合成生物学在开发治疗药物方面大有可为。在本综述中，我们将讨论微生物生产者工程和利用合成生物学方法在微生物中生产人参皂苷的最新进展。

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来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.