Significance and applications of carbon dots in anti cancerous nanodrug conjugate development: A review

IF 7.5 Q1 CHEMISTRY, PHYSICAL Applied Surface Science Advances Pub Date : 2023-12-30 DOI:10.1016/j.apsadv.2023.100550
Vinay Kumar Pandey , Anjali Tripathi , Anam Taufeeq , Aamir Hussain Dar , Antony V Samrot , Sarvesh Rustagi , Sumir Malik , Tanima Bhattacharya , Ayaz Mukarram Shaikh , Béla Kovács
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Abstract

Carbon-based nanoparticles known as Carbon Dots (CDs) have attracted a lot of interest in the field of cancer therapy because of their special physicochemical characteristics and biocompatibility. They are attractive carriers for drug delivery systems due to their surface functional ability, superior water solubility, and size-dependent fluorescence. CDs are unique in that they have a large surface area, adjustable surface chemistry, and a remarkable ability to carry anticancer medications. Their lower systemic toxicity, regulated drug release, and capacity to get beyond biological barriers have completely changed the way that drugs are delivered. CDs have a variety of uses in the creation of anti-tumor nanodrug conjugates. CDs have been used in combination therapy, a multimodal strategy for cancer treatment that involves co-delivering various medications for synergistic benefits. The incorporation of CDs into anticancerous has-drug conjugates represents a noteworthy progression in the treatment of cancer medication delivery systems have been revolutionized by their capacity to improve medication stability, target specificity, and controlled release, which holds the promise of more effective and customized treatments. This review article deals with the synthesis of carbon dot-mediated nanodrug conjugate and their roles in cancer therapy.

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碳点在抗癌纳米药物共轭物开发中的意义和应用:综述
被称为碳点(CD)的碳基纳米粒子因其特殊的理化特性和生物相容性,在癌症治疗领域引起了广泛关注。由于碳点具有表面功能性、优异的水溶性和随尺寸变化的荧光性,它们是药物输送系统中极具吸引力的载体。CD 的独特之处在于其具有较大的表面积、可调的表面化学性质以及携带抗癌药物的卓越能力。其较低的全身毒性、可调节的药物释放以及超越生物屏障的能力彻底改变了药物的输送方式。CD 可用于制造抗肿瘤纳米药物共轭物。CD 已被用于联合疗法,这是一种多模式癌症治疗策略,包括联合递送各种药物以产生协同效应。将 CD 纳入抗癌药物共轭物代表了癌症治疗领域的一个显著进步,CD 能够提高药物的稳定性、靶向特异性和控释性,为更有效和个性化的治疗带来了希望。本文综述了碳点介导的纳米药物共轭物的合成及其在癌症治疗中的作用。
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CiteScore
8.10
自引率
1.60%
发文量
128
审稿时长
66 days
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