The prevalence of IgE positivity, environmental factors, and clinical implications associated with mite species in allergic patients in Taiwan.

IF 2.3 4区 医学 Q3 ALLERGY Asian Pacific journal of allergy and immunology Pub Date : 2024-01-06 DOI:10.12932/AP-270623-1644
Chun-Hsien Hsu, Ding-Kuo Chien, Jaw-Ji Tsai, Chung-Yang Yen, En-Chih Liao
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Abstract

Background: Allergic diseases are a growing public health concern with increasing prevalence and severity. Allergens play significant roles in triggering immune responses and the development of allergic reactions.

Objective: Investigate the presence and clinical significance of dust mites, storage mites, and predatory mite Cheyletus eruditus(Ce) in household environments.

Methods: A survey of household dust was performed to determine mite occurrence and analyze influencing factors, an analysis of the correlation between mite species and allergic symptoms, and basophil activation triggered by mite allergens. Cross-reactivity between Ce and house dust mites was assessed.

Results: The high appearance rate of mite species in households of Taiwan was Dermatophagoides pteronyssinus (Dp) and D. farinae(Df). Environmental factors such as pet keeping, vacuum cleaner usage, air conditioner usage, proximity to the kitchen, cleaning frequency, and protein concentration in beds were shown to influence mite prevalence. The appearance of Dp and Df significantly increased the occurrence of airway and nasal symptoms, while the presence of Ce was strongly correlated with skin symptoms. The activation of basophils and the correlation between specific IgE levels and allergic symptoms in response to Ce exposure were demonstrated. The presence of Ce was associated with elevated levels of allergens in bedding. The IgE adsorption between mite species was demonstrated suggesting cross-reactivity between the Ce and Dp was limited. Presence of Ce is associated with elevated levels of major mite allergens in beddings.

Conclusion: Allergenicity of Ce was confirmed by IgE reactivity and basophil activation regarding mite infestation as a potential cause of skin-related allergy.

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台湾过敏症患者的 IgE 阳性率、环境因素以及与螨虫种类相关的临床影响。
背景:过敏性疾病是一个日益严重的公共卫生问题,其发病率和严重程度都在不断上升。过敏原在引发免疫反应和过敏反应的发生中起着重要作用:调查家庭环境中尘螨、储藏螨和捕食螨 Cheyletus eruditus(Ce)的存在及其临床意义:方法: 对家庭灰尘进行调查,以确定螨虫的发生率并分析影响因素,分析螨虫种类与过敏症状之间的相关性,以及螨虫过敏原引发的嗜碱性粒细胞活化。评估了 Ce 和屋尘螨之间的交叉反应:结果:台湾家庭中出现率较高的螨虫种类是Dermatophagoides pteronyssinus (Dp)和D. farinae (Df)。饲养宠物、使用吸尘器、使用空调、靠近厨房、清洁频率和床的蛋白质浓度等环境因素都会影响螨虫的出现。Dp和Df的出现会明显增加气道和鼻腔症状的发生,而Ce的出现则与皮肤症状密切相关。嗜碱性粒细胞的活化以及特异性 IgE 水平与接触 Ce 后的过敏症状之间的相关性得到了证实。Ce 的存在与床上用品中过敏原水平的升高有关。螨虫种类之间的 IgE 吸附作用得到了证实,这表明 Ce 和 Dp 之间的交叉反应是有限的。结论:Ce 的存在与床上用品中主要螨虫过敏原水平的升高有关:结论:通过 IgE 反应和嗜碱性粒细胞激活证实了 Ce 的致敏性,螨虫侵袭是皮肤相关过敏的潜在原因。
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来源期刊
CiteScore
12.80
自引率
0.00%
发文量
74
审稿时长
>12 weeks
期刊介绍: The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.
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