{"title":"Eco-friendly and Regiospecific synthesis of Novel (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide Derivatives","authors":"Amer Amer, Doaa H. Ahmed, A. Moustafa","doi":"10.21608/sjsci.2023.232963.1120","DOIUrl":null,"url":null,"abstract":": The Ultrasonic (US) technique is used in the present work as an eco-friendly method for the synthesis of (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide derivatives. A simple and efficient method has been described for the alkylation of (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide ( 1 ). Besides the IR and NMR spectra, the regioselectivity of the N -alkylation is chemically achieved. Furthermore, fusion of sodium salt of 1 with ethyl bromide in DMF as solvent using ultrasound irradiation as a source of power afforded (1,3-diethyl-5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide ( 9 ).","PeriodicalId":146413,"journal":{"name":"Sohag Journal of Sciences","volume":"1 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sohag Journal of Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/sjsci.2023.232963.1120","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
: The Ultrasonic (US) technique is used in the present work as an eco-friendly method for the synthesis of (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide derivatives. A simple and efficient method has been described for the alkylation of (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide ( 1 ). Besides the IR and NMR spectra, the regioselectivity of the N -alkylation is chemically achieved. Furthermore, fusion of sodium salt of 1 with ethyl bromide in DMF as solvent using ultrasound irradiation as a source of power afforded (1,3-diethyl-5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide ( 9 ).
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