Potential of Bioactive Compounds for Atopic Dermatitis

Abstract

Atopic Dermatitis (AD) is a complicated condition that places tremendous physiological and psychological strain on individuals. Natural products have long been used to cure diseases such as cancer, asthma, gastrointestinal disorders, neurological disorders, and infections. The study findings reveal that natural compounds, particularly quercetin, gallic acid, and ginsenosides, have promised preventive effects against atopic dermatitis. The study addresses the medicinal properties of bioactive compounds and emphasizes their ability to exert anti-inflammatory action. These compounds exhibit anti-inflammatory properties by reducing the quantity and functionality of various inflammatory cells such as cytokines neutrophils, monocytes, lymphocytes, Langerhans cells, interleukins (ILs, such as IL-1 IL-5, and IL-4, IL-13, and IL-31), TNF-α, TSLP, and IgE, etc. The studies would pave the way for the development of natural compounds specifically designed to treat atopic dermatitis in humans. Atopic dermatitis is routinely treated using bioactive and phytoconstituents derived from them. As a result, the review emphasizes recent advances in understanding the clinical characteristics, etiology, pathogenesis, treatment with bioactive compounds, and management of atopic dermatitis.