The Synthesis of Some Imine Derivatives via Condensation Reactions between Some Aromatic Phenylhydroxylamine Derivatives with Glyoxylic Acid and the Study of their biological activity

Abstract

This study investigated the condensation reactions between N-(3,4-dimethoxybenzyl)hydroxylamine and N-(4-methylbenzyl)hydroxylamine with glyoxalic acid. The objective was to obtain imine derivatives as the desired target products. FT-IR, 1H-NMR, and    13C-NMR spectroscopic techniques were used to identify the structures of the produced compounds. Different conditions were considered for these reactions and only N-(3,4-dimethoxybenzyl)hydroxylamine could be converted to the desired nitrone. Finally, the antimicrobial efficacy was assessed in terms of its action against the bacteria Escherichia coli (E.coli) as Gram-negative bacteria, Staphylococcus aureus (S.aureus) as Gram-positive bacteria and fungus (Candida albicans). The activity data proved that this nitrone showed significant antimicrobial activity compared to standard drugs.