Subconjunctival administration of "Actilize" for the treatment of small hemorrhages in the anterior chamber of the eye in cats with arterial hypertension

Abstract

Systemic arterial hypertension can occur in  cats  for  a number of  reasons.  The  most common causes of hypertension in cats include  kidney  disease  (chronic  kidney  disease, chronic interstitial nephritis, amyloidosis, glomerulonephritis, pyelonephritis, polycystic  kidney  disease,  renal  dysplasia,  as well  as  acute  renal  failure),  chronic  heart failure,  endocrinopathy  (diabetes  mellitus, hyperthyroidism,  etc.),  obesity (hyperlipidemia), chronic anemia, polycythemia, fever, arteriovenous fistula, the use of food with a high salt content, idiopathic factors. Taking into account the above, we set a goal –  to  introduce  into  veterinary  clinical practice  an  effective  fibrinolytic  "Actilize"; to establish its effectiveness in lysis of small hemorrhages in the anterior chamber of the eye with arterial hypertension of cats, as well as prevention and treatment of synechiae; to work  out  a  subconjunctival  method  of  administration of "Actilize" at the entrance of long  ciliary  arteries.  The  basis  of  the  research  methodology  was  a  scientifically based formulation of the problem, methods and means of lysis of small blood clots in the anterior chamber of the eye, prevention and treatment  of  synechiae  in  cats  with  arterial hypertension,  ensuring  maximum  effectiveness by improving existing treatment protocols,  as  well  as  testing  "Actilize"  and  the subconjunctival method of its introduction in the area of the entrance of long ciliary arteries  for  treatment  small  hemorrhages  in  the anterior  chamber  of  the  eye  with  arterial hypertension  of  cats  in  veterinary  ophthalmology. Thanks to the experiments, we were able  to  introduce  into  veterinary  clinical practice an  effective fibrinolytic "Actilize"; to establish its effectiveness in lysis of small blood  clots  in  the  anterior  chamber  of  the eye  with  arterial  hypertension  of  cats,  prevention and treatment of synechiae; to work out  a  minimally  invasive  subconjunctival method of administration of "Actilize" at the entrance of long ciliary arteries. In the case of extensive hyphema with arterial hypertension  of  cats,  followed  by  the  formation  of large blood clots, we recommended an intracameral  method  of  introducing  "Actilize" into the anterior chamber of the eye.